PECULIARITIES OF CHRONIC INFLAMMATORY PROCESS IN GASTRIC MUCOSA DEPENDING ON MOLECULAR-GENETIC CHARACTERISTIC OF HELICOBACTER PYLORI IN ADOLESCENTS

Aim. To establish the peculiarities of chronic inflammatory process in gastric mucosa depending on molecular-genetic characteristic of Helicobacter pylori ( Hp ) in adolescents. Materials and methods. Endoscopic and morphological examination of 56 adolescents aged 15-18 years with Hp -associated chronic gastroduodenitis was carried out. Genetic typing of Hp was performed in gastrobiopsy material. Results. High frequency (42,86 %) of high-pathogenic Hp strains with detection of VacA, CagA, IceA, BabA and Urel-subunit of urease was stated. Inflammatory process involving Hp with such molecular-genetic characteristics was proved to be well marked and active. The degree of inflammation directly correlates with occurrence of microerosions, hyperplasia foci and morphological signs of initial gastric mucosa atrophy.

Helicobacter pylori, Gastric mucosa, inflammation, Helicobacter pylori, adolescents