BIOLOGICAL AGE DETERMINATION IN PATIENTS WITH CHRONIC HEART FAILURE

Aim. To determine the biological age of patients of senior age groups with chronic heart failure (CHF) of different functional classes treated at the hospital for war veterans so as to establish their individual rate of ageing. Materials and methods. 86 male patients aged 72–96 (82,436±4,624) hospitalized to Geriatric Unit of Perm Regional Hospital for War Veterans who against the background of ischemic heart disease and arterial hypertension had functional classes I–IV CHF were examined. CHF severity was assessed by NYHA classification functional classes. The comparison group included 10 men aged 80,88±1,902 without clinical cardiovascular system (CVS) manifestations. Out of all standard protocol indices of echocardiogram characterizing morphofunctional CVS status, the most changeable while ageing (correlation coefficient 0,8 and more) and minimally correlating between each other parameters were chosen using the method of discriminant analysis. So, we took into consideration the following echocardiographical indices: AOd – aortal orifice diameter; LA – left atrium size, mm; VST – vetntricular septum thickness, mm. Besides, biological age (BA), due biological age (DBA) and individual BA and DBA difference index (∆T) were determined. Statistical processing of the obtained results was performed using t-Student’s test. Results. For the group of comparison, the delayed rate of aging and for CHF patients the accelerated aging with ∆T>0 (or BA/DBA>1) was established. At the same time, in patients with FCII, the degree of aging was not significantly increased, but in patients with FC III–IV CHF it was accelerated. (comparison group – FC III–IV, p 0 – III–IV£0,005). Conclusion. Biological age of the examined patients without clinically marked CVS pathology is significantly lower than the population standard that reflects the delayed rate of aging. Functional class II–IV CHF negatively influences the rate of aging and viability, raises the rate of patients’ aging, thus, significantly reducing the adaptive patency of the body and increasing the probability of death. The method of BA determination is easy-to-use in conditions of functional polyclinic and hospital units. Consequently, BA determination can be used for annual deepened medical examinations. Knowledge of age standards for patient’s circulation system and BA is to be taken into account while choosing medical tactics and giving recommendations regarding the mode of life.

Biological age, rate of aging, chronic heart failure, echocardiography