PATHOGENETIC APPROACH TO CORRECTION OF TRAUMATIC DISEASE MANIFESTATIONS

Aim. To determine the pathogenetic efficiency of antioxidant therapy in correction of hemostasis disorders of traumatic disease. Materials and methods. The work is based on materials of clinicolaboratory investigations of patients with long cortical bone fractures. In the main group, complex therapy was added by antioxidant mexidol. Results. It was shown that in traumatic damages there occurs a marked syndrome of endogenous intoxication which is accompanied by essential disturbance of functional erythrocyte status conditioned by membrane-destabilizing phenomena based on lipid metabolism disorders. Application of antioxidant mexidol in patients with long cortical bone fractures leads to significant reduction of expression of hemostatic disturbances connected with traumatic disease and surgical aggression. Conclusion. Efficiency of this drug is conditioned by its ability to significantly decrease expression of membrane-destabilizing processes at the expense of lowering (by 11,5–27,5%) lipid peroxidation intensity and phospholipase activity (by 14,4–31,8%).

Traumatic disease, endogenous intoxication, mexidol, liids