Neurobiological mechanisms of the rewars and punishment systems in the brain afteractivation of nucleus accumbens



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Abstract

The review devoted to neurobiological mechanisms of both positive and negative reinforcement is represented. The key role in these processes plays the nucleus accumbens as a part of the extended amygdala system. The afferent and efferent connections of the n.accumbens, starting mechanisms of the n.accumbens involvement in emotional reactions, interactions between n.accumbens and other structures of the extended amygdala system, and neurochemical organization of the n.accumbens and all system of reinforcement are discussed in the article. The special attention is taken to the n.accumbens participation in addictive behavior.

About the authors

Mariya Vladimirovna Sheveleva

Institute of Experimental Medicine, NWB RAMS

Email: shevelevamary@yandex.ru
Fellow (Pharmacology), Anichkov Dept. of Neuropharmacology

Andrey Andreyevich Lebedev

Institute of Experimental Medicine, NWB RAMS

Email: aalebedev@yandex.ru
Dr. Biol. Sci. (Physiology), Professor, Senior Researcher, Anichkov Dept. of Neuropharmacology

Roman Olegovich Roik

Institute of Experimental Medicine, NWB RAMS

PhD (Pharmacology), Senior Researcher, Anichkov Dept. of Neuropharmacology

Petr Dmitriyevich Shabanov

Institute of Experimental Medicine, NWB RAMS

Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor and Head, Anichkov Dept. of Neuropharmacology

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