Vol 10, No 1 (2012)

On model of acute intoxication of karbofos, dichloroethane and etilenglikoly (all 256 ± 8.7 mg/ kg) at rats studied mechanisms of protective action of derivatives of tiobenzimidazole (metaprot and etomerzol) 25 and 50 mg/kg. Both preparations renewed of tolerance of physical activity, normalized activity of ASAT, ALAT, reduced levels of bilirubin, a creatinine and urea nitrogen. Impact on processes of lipid peroxidation was expressed in decrease in concentration low-new of dialdehyde and increase of levels restored of glutathione, indicators of endogenous intoxication were thus eliminated. Anti-hypoxemic, antioxidant, aktoprotektorny, energotropny, reparation effects metaprot and etomerzol are proved.

In animal experimental model the ulcerogenic effect of non-selective and selective inhibitors of cyclooxigenase has been estimated. The all tested remedies influenced morphology of liver and mucosa of stomach. Meanwhile the reaction of each animal on non-steroidal anti-inflammatory drugs was individual. It has been elucidated that ketorolac significantly down-regulated prostaglandin E2 production in gut mucosa. Nimesulide (selective non-steroidal anti-inflammatory drug) significantly up-regulated the activity of aspartat-aminotransferase in serum of experimental rats. The mechanism of nimesulide hepatotoxicity is being discussed.

The main goal of the current research was to assess memory impairments via learning curves and its restoration during the process of rehabilitative treatment of alcoholic patients having traumatic brain injury with pharmacological correction. We applied a mathematical model Y = B3*exp(-B2*(X-1))+B4*(1-exp(-B2*(X-1))), where X is the trial number; Y is the number of recalled correct words, B2 is the learning rate, B3 is readiness to learn and B4 is ability to learn. Readiness to learn and ability to learn were significantly below in alcoholic patients in comparison with healthy participants. Treatment with vasorelaxants Cinnarizine and Dibazol, central muscle relaxant Baclofen, nootropics Nootropil and Aethimizol, as well as actoprotector Metaprot (Bemithyl) returned readiness to learn up (shortterm memory) to normal values. However, ability to learn (long-term memory) was restored only with Dibazol. Use of 10 words in a list of Luria's memory test is insufficient for exact assessment of the long-term memory and should be increased up to 16 words.

Proceeding from the proposition about the high productivity of the search of neuropsychotropic substances among the derivatives of natural neuromediators, a study of neuropsychopharmacological effects of the derivative of the glutamic acid, RGPU-197 compound was carried out. The study was carried out on the he-rats of the Wistar line using the following tests: “open field”, elevated plus maze, conditioned passive-avoidance response, the test of extrapolational deliverance, the test of hanging mice by tails; and also the methods of statistic analysis: rank univariate analysis of Cruscal-Wallace, the Dunn multiple comparison test /the multiple comparison test of Dunn, the x2 criterion. The RGPU-197 compound significantly (p<0,05, p<0,01) decreases the duration of immobilization of the animals and expands the latent period of its approach in the test of hanging mice by tails — it possesses antidepressant activity; increases the quantity of the visits of the centre of the open field, the quantity of attendings of the open hoses of elevated plus maze and the time of stay in them — it shows anxiolytic action; increases the quantity of crossed squares in the open field and the quantity of crossings between the hoses of elevated plus maze — it possesses activating effect; during the displays of the avoidance reflex it expands the latent period of the first period of entering the dark compartment and the quantity of enterings of it in conditioned passive-avoidance response, reduces the latent period of diving under in the test of extrapolational deliverance — it shows nootropic action. According to the intensity of antidepressant action RGPU-197 doesn’t yield to melipramin, anxiolytic and activating effects significantly (p<0.05) excels phenibutum and doesn’t yield to it by nootropic activity. Thus, the new derivative of glutamate, the RGPU-197 compound, possesses the marked antidepressant, anxiolytic and activating effects, as well as nootropic activity.

В статье приводятся данные по гистоморфологии пузырьковидных желез яка в послеутробный период развития.