The association gene polymorphisms with risk of cancer in long-term «low-dose» y-irradiation exposure



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Abstract

The association of 13 biallelic polymorphisms of genes hOGG1 977C > G, XPD1 2251A > C, XPG1 3310G > C, XRCC1:580C> T, 839G >A, 1196G>A GSTT1 («+»/«-»), GSTM1 («+»/«-»), CYP2C19 681G> A, NOS3: -665C>T, 774С> T, 894G > T, VNTRint4 with risk of development of malignant new growths (MNG) in conditions of "low-dose" ionizing irradiation was investigated. In 1 group of irradiated patients of malignant new growths there are 96 persons, in 2 group of non-irradiated patients of MNG - 135 persons, in 3 control group - 148 healthy irradiated workers of the Siberian Group of Chemical Enterprises. By means of procedure FDR it is shown that only polymorphic variants of gene CYP2C19681G* are authentically associated with risk of occurrence of MNG against an irradiation. 1 genotype consisting of a combination of 5 polymorphic loci is selected. Frequency of occurrence of this genotype in 1 group makes 16,9 % (14/83), in 2 group - 1,0 % (1/100), in 3 group - 0,84 % (1/119). At its carriers in conditions of low-dose irradiation more than in 20 times the risk of occurrence of MNG (OR between 1 and 3 groups (95 % CI) = 24,14 (3,21-502,64) increases; p = 0,0000581, taking into account the correction of Bonferroni р = 0,01046).

About the authors

Nikolay V Litvjakov

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: nvlitv72@sibmail.com

Maksim B Freydin

Research Institute of Medical Genetics, Tomsk, Tomsk Oblast, RF

Email: mfreidin@medgenetics.ru 634050, Tomsk, Naberezhnaya r. Ushayki, 10. Russia

Ravil M Takhauov

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: mail@sbrc.ru

Alena M Ageeva

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: mail@sbrc.ru

Natalia M Volkova

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: mail@sbrc.ru

Polina V Ivanina

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: ivaninap@mail.ru

Olesya O Goncharik

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: goo15@ngs.ru

Elena O Vasilyeva

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: veo2109@rambler.ru

Elena V Skobelskaya

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: mail@sbrc.ru

Andrey B Karpov

Seversk Biophysical Research Centre, Seversk, Tomsk Oblast, RF

Email: mail@sbrc.ru

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Copyright (c) 2009 Litvjakov N.V., Freydin M.B., Takhauov R.M., Ageeva A.M., Volkova N.M., Ivanina P.V., Goncharik O.O., Vasilyeva E.O., Skobelskaya E.V., Karpov A.B.

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