Epigenetical mechanisms of susceptibility to complex human diseases



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Abstract

Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.

About the authors

Eugene L Patkin

Institute of Experimental Medicine, St. Petersburg, RF

Email: elp44@mail.ru

John Quinn

School of Biomedical Science, Medical School,University of Liverpool, Liverpool, UK

Email: Jquinn@liv.ac.uk

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