The influence of D. melanogaster mutations of the kynurenine pathway of tryptophan metabolism on locomotor behavior and expression of genes belonging to glutamatergic and cholinergic systems



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Abstract

Disbalance of kynurenines produced by Drosophila mutations of the kynurenine pathway of tryptophan metabolism influences the locomotor behavior in larvae. The most pronounced is the effect of accumulation of kynurenic acid in the mutant cinnabar manifested as sharp reduction of general level of locomotor activity. The mutations seem to act through modulatory influences of kynurenines on signal cascades governed by ionotropic glutamatergic and cholinergic receptors. Expression of receptor genes in the mutants shows age-related changes pointing to gradual evolvement of consequences of kynurenines disbalance.

About the authors

Gennady A Zakharov

I.P. Pavlov Institute of Physiology, RAS, Saint-Petersburg, RF

Email: Gennadiy.Zakharov@gmail.com Saint-Petersburg, 199034 Makarova emb., 6, Russia

Alexander V Zhuravlev

I.P. Pavlov Institute of Physiology, RAS, Saint-Petersburg, RF

Email: beneor@mail.ru

Tatyana L Payalina

I.P. Pavlov Institute of Physiology, RAS, Saint-Petersburg, RF

Email: payalina@mail.ru Saint-Petersburg, 199034 Makarova emb., 6, Russia

Nikolay G Kamyshev

I.P. Pavlov Institute of Physiology, RAS, Saint-Petersburg, RF

Email: nkam@pavlov.infran.ru; nkamster@gmail.com

Elena V Savvateeva-Popova

I.P. Pavlov Institute of Physiology, RAS, Saint-Petersburg, RF

Email: esavvateeva@mail.ru Saint-Petersburg, 199034 Makarova emb., 6, Russia

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