SIGNIFICANCE OF VASCULAR ENDOTHELIUM GROWTH FACTOR IN ENDOTHELIAL DYSFUNCTION AMONG PATIENTS WITH METABOLIC SYNDROME

Aim. The objective of our study was to investigate the status of endothelium in patients with metabolic syndrome. Metabolic syndrome (MS) is a block of hormonal and metabolic disorders united by a common pathophysiological mechanism - insulin resistance (IR). The connecting link between IR and cardiovascular diseases is endothelial dysfunction. Materials and methods. The problem was solved by means of assessment of vascular tonus changes using skin temperature range wavelet-analysis and VEGF determination while performing indirect cold test. Results. Serum VEGF concentration in MS patients was reliably higher than in practically healthy persons. In patients with MS, cold test response significantly differed from the control group. While carrying out cold test, the amplitude reliably decreased in endothelial and neurogenic bandwidth without its rise by the end of the study. There was revealed a reliable direct correlation between VEGF and BMI ( r =0,59; p <0,05), VEGF and WC ( r =0,58; p <0,05), VEGF and DAP ( r =0,57; p <0,05), VEGF and total cholesterol levels ( r =0,74; p <0,05). Conclusion. Thus, endothelial dysfunction in MS patients is displayed by impaired vasodilation in physiological cold test, but increase in patients’ VEGF level can be considered as an additional marker of cardiovascular risk.

Metabolic syndrome, endothelial dysfunction, vascular endothelium growth factor, insulin resistance