Effect of astressin, a corticoliberin antagonist, on aggression and anxiety-fobic states in male rats reared in social isolation

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Abstract


Aim. Intraspecific behavior, emotional and explorative activity were investigated after intranasal administration of astressin, a non-selective antagonist of CRF receptors, in the male rats reared in social isolation from 21 to 93 days.

Results. In the “resident-intruder” test there was an increased level of aggression and communications in isolated rats compared to grouped animals. After intranasal administration of astressin (20 μg in 20 μl), rats grown in isolation demonstrated an increase in aggression and decreased in communicability compared to intact animals reared in isolation. In the “open field” test a level of motor activity was increased in rats grown in isolation compared to grouped animals. The anxiety-phobic state, as well as behavior in an elevated plus maze, revealed enhance of anxiety and fear in rats reared in isolation. After astressin administration to isolated animals the levels of anxiety and fear significantly decreased.

Conclusion. The results of the work revealed that the antagonist of the CRF receptor astressin disinhibited aggression, removing anxious and phobic state in male rats reared in social isolation. The results prove the necessity of taking into account CRF mechanisms in the formation of the social isolation syndrome and the possibility of using CRF receptor antagonists to control the central mechanisms of stress and dependence in ontogenesis.


Andrei A. Lebedev

Author for correspondence.
aalebedev-iem@rambler.ru
Institute of Experimental Medicine
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Dr Biol Sci (Pharmacology), Leading Researcher, S.V. Anichkov Dept. of Neuropharmacology

Anna G. Pshenichnaya

bychkov@mail.ru
Institute of Experimental Medicine
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Researcher, S.V. Anichkov Dept. of Neuropharmacology

Natalia D. Yakushina

bychkov@mail.ru
Institute of Experimental Medicine
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Post-graduate Student, S.V. Anichkov Dept. of Neuropharmacology

Eugenii R. Bychkov

bychkov@mail.ru
Institute of Experimental Medicine
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

PhD (Biochemistry), Leading Researcher, S.V. Anichkov Dept. of Neuropharmacology

Petr D. Shabanov

pdshabanov@mail.ru
Institute of Experimental Medicine
Russian Federation, 12, Academic Pavlov street, Saint-Petersburg, 197376

Dr Med Sci, Professor, Head, S.V. Anichkov Dept. of Neuropharmacology

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