Antihistamine activity of the new peptidepreparation from the cod liver

Kirill Leonidovich Kryshen; Крышень Кирилл Леонидович; Dmitriy Valentinovich Demchenko; Демченко Дмитрий Валентинович; Olga Nikolayevna Pozharitskaya; Пожарицкая Ольга Николаевна; Marina Nikolayevna Makarova; Макарова Марина Николаевна; Yaroslav Aleksandrovich Gushchin; Гущин Ярослав Александрович; Anna Vladimirovna Rybakova; Рыбакова Анна Владимировна; Anastasiya Vladimirovna Rydlovskaya; Рыдловская Анастасия Владимировна; Aleksandr Nikolayevich Shikov; Шиков Александр Николаевич; Valeriy Gennadyevich Makarov; Макаров Валерий Геннадьевич

doi:10.17816/RCF10449-53

Antihistamine activity of the new peptidepreparation from the cod liver

Authors: Kryshen K.L.¹, Demchenko D.V.², Pozharitskaya O.N.², Makarova M.N.¹, Gushchin Y.A.¹, Rybakova A.V.², Rydlovskaya A.V.², Shikov A.N.¹, Makarov V.G.¹
Affiliations:
1. Mechnikov North-West State Medical University
2. Saint-Petersburg institute of pharmacy
Issue: Vol 10, No 4 (2012)
Pages: 49-53
Section: Articles
URL: https://journals.eco-vector.com/RCF/article/view/749
DOI: https://doi.org/10.17816/RCF10449-53
ID: 749

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Abstract

The effect of the peptide substance on the induced production of histamine by culture of basophile, interaction of the preparation with the H1-histamine receptors and possible sedative effect on animal models were studied. The introduction of the peptide substance in cell culture of basophile didn’t have a significant effect on the histamine release. Study of the interaction of the polypeptide substance with H1-histamine receptors of guinea pig ileum showed that the preparation inhibits the response of unstriated muscles to histamine. The effect was similar to antihistamine drug - ketotifen. In the models of “open field” and “elevated criss-cross labyrinth” it was found that the peptide preparation hasn’t a sedative effect.

Keywords

peptide preparation, histamine, basophiles, cell culture, sedative activity

References

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Antihistamine activity of the new peptidepreparation from the cod liver

Full Text

Abstract

Keywords

About the authors

References

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