Binding Site For Glucocorticoid Receptor On DNA And Structural Variants Of Glucocorticoid Responsive Elements: Analysis Of GR-TRRd



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Abstract

GR-TRRd section of TRRd database accumulates the largest out of currently published samples of nucleotide sequences that are experimentally proved to bind glucocorticoid hormone receptor (GR). This sample consists of 160 glucocorticiod receptor binding sites (GRbss) from vertebrate genes controlled by glucocorticoids. analysis of the sample has shown that the structure of only half of GRbss (54%) corresponds to traditional viewpoint about structural organization of glucocorticoid response element (GRE) as an inverted repeat of hexameric half-site sequence TGTTCT. 40% of GRbss contain only hexameric half-site. Notably, there exist experimental evidence about participation of most of these GRbss in glucocorticoid regulation. as a result of increasing the number of sequences in the sample of GRbss, we have specified the consensus of sites organized in a form of inverted repeat (palindromic GREs). On the basis of literature data several possible mechanisms of action of noncanonical GRbss containing hexameric half-sites in glucocorticoid induction are proposed.

About the authors

Vasiliy M Merkulov

Institute of Cytology and Genetics SB RAS, Novosibirsk, Novosibirsk Oblast, RF

Tatyana I Merkulova

Institute of Cytology and Genetics SB RAS, Novosibirsk, Novosibirsk Oblast, RF

Email: merkti@niboch.nsc.ru

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