Advisability of using early generation Cephalosporines for prevention and treatment of postpartum infection

Cover Page


Introduction: the following research investigates an availability of a long-lime treatment of postpartum infection by using of Cephalozolin (the Cephalosporine of generation I).

Matherials and Methods. Lochia samples were obtained from the uterine cavities of 21 puerperal women who did not receive drug after delivery and were cultured for the identification and the determination of the susceptibilities of the clinical isolates to Cephalozolin. The concentrations of Cephalozolin in the supernatants were measured by highperformance liquid chromatography.

Results. We determined the sensivity of the most clinically important bacteria to Cephazoline and its penetration rate to the uterine cavity. We found out the following bacteria which are sensible to Cephazoline – S. agalactiae, E. coli, K. pneumoniae, E. aerogenes. A low rate of Cephazoline ≤ 0,78 mg/ml was inhibited the growth of mentioned above bacteria. Cephazoline is also active as for S. aureus – MIC90 and was equal 3.13 mg/ml. In 3 hours after the injection of 1.0 gr of Cephazoline there was a maximum concentration in a venous blood – 1.63 mg/ml. The concentration of Cephazoline in lochia was rising gradually and it maximum in the uterus cavity in 5 hours was 1.26 mg/ml, and then its slowly went down.

Conclusions. The mention above results let us suggest that Cephazoline is penetrates actively to lochia and its still has a good antibacterial effect. Cephazoline is still a treatment of choice as for prevention and a treatment of postpartum surgical site infections by a sensitive microorganism.

Nikolay A. Korobkov

Author for correspondence.
North-Western State Medical University named after I.I. Mechnikov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015

Chair of reproductive health of women

  • Rayburn W, Varner M, Galask R, et al. Comparison of moxalactam and cefazolin as prophylactic antibiotics during cesarean section. Antimicrob Agents Chemother. 1985;27(3):337-9.
  • Коробков Н.А. Антибиотикорезистентность грамположительной микрофлоры, выделенной из метроаспирата у родильниц с послеродовым эндометритом // Уральский медицинский журнал. – 2015. – № 3. – С. 73–78. [Korobkov NA. Antibiotic-resistant gram-positive microflora isolated from metro aspirates in parturients with postpartum endometritis. Ural’skij medicinskij zhurnal. 2015;(3):73-78. (In Russ.)]
  • Коробков Н.А. Аэробные грамотрицательные возбудители послеродовых инфекций в акушерском стационаре: проблемы антибиотикорезистентности // Фарматека. – 2015. – № 12. – С. 29–32. [Korobkov NA. Ajerobnye gramotricatel’nye vozbuditeli poslerodovyh infekcij v akusherskom stacionare: problemy antibiotikorezistentnosti. Farmateka. 2015;(12):29-32. (In Russ.)]

Supplementary files

There are no supplementary files to display.


Abstract - 33

PDF (Russian) - 23

Copyright (c) 2017 ECO-vector LLC

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.