Factors influencing survival of patients suffering from nonspecific aortoarteritis

Cover Page

Abstract


Aim. To identify the factors influencing survival of patients with Takayasu arteritis with the use of Kaplan-Meier mono-factor analysis.

Methods. As the factors influencing survival we analyzed gender, smoking status, tachycardia, arterial hypertension, comlications, left common iliac artery involvement, character of disease progression, and social factors. 96 patients suffering from nonspecific aortoarteritis and observed in Regional clinical hospital №1 in 1998-2016 were examined.

Results. Survival of patients suffering from nonspecific aortoarteritis was influenced by: male gender (p=0.0030), smoking (р=0.00762), tachycardia at the time of diagnosis (p=0.01762), arterial hypertension at the time of diagnosis (p=0.04150), involvement of left common iliac artery (p=0.02970), more than 3 complications (p=0.00062), progressive course of the disease (p=0.00016), being divorced (p=0.00018). 5-year survival was 99%, 10-year survival - 95%, 15-year survival - 93%.

Conclusion. The following factors were identified as influencing survival of patients with Takayasu arteritis: male gender, smoking, tachycardia and arterial hypertension at the time of diagnosis, involvement of left common iliac artery, more than 3 complications, progressive course of the disease and being divorced.


I E Borodina

Author for correspondence.
borodysik@mail.ru
Regional Clinical Hospital №1; Ural State Medical University Ekaterinburg, Russia; Ekaterinburg, Russia

L A Shardina

borodysik@mail.ru
Ural State Medical University Ekaterinburg, Russia

  • Михайлова А.Е., Кривошапкин В.Г., Протопопова Р.П. и др. Качество жизни больных остеоартрозом в г. Якутске. Науч.-практ. ревматол. 2005; (2): 11-14. doi: 10.14412/1995-4484-2005-1517.
  • Насонов Е.Л., Баранов А.А. Современные представления об этиологии и патогенезе системных васкулитов. Клин. мед. 1998; (7): 5-11.
  • Волосников Д.К., Глазырина Г.А., Серебрякова Е.Н. и др. Неспецифический аортоартериит (артериит Такаясу) у детей и подростков: обзор литературы и описание клинического случая. Трудный пациент. 2015; 13 (1-2): 36-39.
  • Смитиенко И.О. Клинические варианты органных поражений, оценка активности и прогноза артериита Такаясу. Автореф. дисс.. канд. мед. наук. 2010; 22 с.
  • Ishikawa K., Maetani S. Long-term outcome for 120 Japanese patients with Takayasu’s disease. Clinical and statistical analyses of related prognostic factors. Circulation. 1994; 90 (4): 1855-1860. doi: 10.1161/01.CIR.90.4.1855.
  • Phillip R., Luqmani R. Mortality in systemic vasculitis: a systemic review. Clin. Exp. Rheumatol. 2008; 26 (5): 94-104. PMID: 19026150.
  • Park M.C., Lee S.W., Park Y.B., Chung N.S. Clinical characteristics and outcomes of Takayasus arteritis: analysis of 108 patients using standardized criteria for diagnosis, activity assessment and angiographic classification. Scand. J. Rheumatol. 2005; 34 (4): 284-292. doi: 10.1080/03009740510026526.
  • Schmidt J., Kermani T.A., Bacani A.K. et al. Diagnostic features, treatment, and outcomes of Takayasu arteritis in a US cohort of 126 patients. Mayo Clin. Proc. 2013; 88 (2): 821-830. doi: 10.1016/j.mayocp.2013.04.025.
  • Balakrishnan K.G. Subramanyan R., Joy J. Natural history of aortoarteritis (Takayasu’s disease). Circulation. 1989; 80 (3): 429-437. doi: 10.1161/01.CIR.80.3.429.
  • Miyata T., Osamo S., Hiroyuki K. Long-term survival after surgical treatment of patients with Takayasus arteritis. Circulation. 2003; 108: 1474-1480. doi: 10.1161/01.CIR.0000089089.42153.5E.
  • Гончарова Н.С., Пахомов А.В. Артериит Такаясу. Обзор литературы. Артериальная гипертензия. 2013; 19 (6): 478-452. doi: 10.18705/1607-419X-2013-19-6-478-476.
  • Кувшинова О.А. Проблемы социального конструкта пожилого возраста. Вестн. Томского гос. ун-та. 2012; (1): 25-26.

Views

Abstract - 56

PDF (Russian) - 82


© 2017 Borodina I.E., Shardina L.A.

Creative Commons License

This work is licensed
under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.