Meibomian gland dysfunction with involutional eyelids malposition

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Abstract

The state of the ocular surface and visual functions depends on ocular adnexal tissues. Involutional changes of the eyelids and meibomian glands occur with age. There is a lack of information about possible relationship between involutional lower lid malposition and meibomian gland dysfunction. Purpose. To evaluate meibomian glands dysfunction in patients with lower eyelid malposition. Methods. Two groups of patients were enrolled: 26 patients (52 eyelids) with involutional lower eyelid malposition and a control group of 22 patients (44 eyelids) without eyelid malposition. Groups were comparable by age and sex. The clinical examination included general eye examination; evaluation of the degree of the eyelids laxity, signs of retractors dehiscence and clinical score of meibomian gland’s dysfunction (The International Workshop on Meibomian Gland Dysfunction, 2011). Results. Atonic eyelid changes and meibomian gland dysfunction were significantly more expressed in patients with involutional eyelid malposition (р < 0,05). Conclusion. Our study showed an age-independent clinical relationship between involutional lower eyelid malposition and dysfunction of meibomian glands.

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About the authors

Vitaly V Potemkin

First Pavlov State Medical University of St. Petersburg

Email: potem@inbox.ru
Ph.D., assistant. Department of Ophthalmology

Vyacheslav V Rakhmanov

First Pavlov State Medical University of St. Petersburg

Email: rakhmanoveyes@yandex.ru
Ph.D., assistant. Department of Ophthalmology

Elena V Ageeva

First Pavlov State Medical University of St. Petersburg

Email: ageeva_elena@inbox.ru
resident. Department of Ophthalmology

Aisa S Alchinova

First Pavlov State Medical University of St. Petersburg

Email: aalchinova@mail.ru
resident. Department of Ophthalmology

Elena V Meshveliani

First Pavlov State Medical University of St. Petersburg

Email: lena_vm@inbox.ru
resident. Department of Ophthalmology

References

  1. Астахов Ю.С., Николаенко В.П. Офтальмология. Фармакотерапия без ошибок. - М., 2016. - С. 307-338. [Astakhov YS, Nikolaenko VP. Oftal’mologiya. Farmakoterapiya bez oshibok. Moscow; 2016:307-338. (In Russ).]
  2. Бровкина А.Ф., Астахов Ю.С. Руководство по клинической офтальмологии. - 2014. - C. 78-118. [Brovkina AF, Astakhov YS. Rukovodstvo po klinicheskoy oftal’mologii. 2014:78-118. (In Russ).]
  3. Лантух В.В. Новые способы микрохирургической окулопластики. - 2005. - № 3. - C. 80-81. [Lantukh VV. Novye sposoby mikrokhirurgicheskoy okuloplastiki. 2005;(3):80-81. (In Russ).]
  4. Николаенко В.П., Астахов Ю.С. Орбитальные переломы. СПб., 2012. - C. 12-79. [Nikolaenko VP, Astakhov YS. Orbital’nye perelomy. Saint Petersburg; 2012:12-79. (In Russ).]
  5. Abelson MB, Holly FJ. A tentative mechanism for inferior punctate keratopathy. Am J Ophthalmol. 1977;(83):866-869. doi: 10.1016/0002-9394(77)90916-3
  6. Bashour M, Harvey J. Causes of involutional ectropion and entropion-age-related tarsal changes are the key. Ophthal Plas Reconstr Surg. 2000;16(2):131-41. doi: 10.1097/00002341-200003000-00008.
  7. Basic and Clinical Sciences Course. External Disease and Cornea. 2011-2012:173-182.
  8. Bron AJ, Benjamin L, Snibson GR. Meibomian gland disease: classification and grading of lid changes. Eye. 1991;5(4):395-41. doi: 10.1038/eye.1991.65.
  9. Callahan A. Reconstructive Surgery of the Eyelids and Ocular Adnexa. Birmingham: Aesculapius; 1966;140-57.
  10. Chew CKS, Hykin PG, Jansweijer C, et al. The casual level of meibomian lipids in humans. Curr Eye Res. 1993;12(3):255-259. doi: 10.3109/02713689308999471.
  11. Dalgleish R, Smith JL. Mechanics and histology of senile entropion. Br J Ophthalmol. 1966;50(2):79-91. doi: 10.1136/bjo.50.2.79.
  12. Damasceno RW, Osaki MH, Dantas PE, Belfort R. Involutional ectropion and entropion: clinicopathologic correlation between horizontal eyelid laxity and eyelid extracellular matrix. Ophthal Plast Reconstr Surg. 2011 Sep-Oct;27(5):321-6. doi: 10.1097/iop.0b013e31821637e4.
  13. Ferreira GC, Patton JS. Inhibition of lipolysis by hydrocarbons and fatty alcohols. J Lipid Res. 1990;(31):889-897.
  14. Foulks G, Bron AJ. A clinical description of meibomian gland dysfunction. Ocul Surf. 2003;(1):107-126.
  15. Geerling G, Brewitt H. Surgery for the Dry Eye. 2008;41.
  16. Han SB, Hyon JY, Woo SJ, et al. Prevalence of dry eye disease in an elderly Korean population. Arch Ophthalmol. 2011;129(5): 633-8. doi: 10.1001/archophthalmol.2011.78.
  17. Harvey DJ, Tiffany JM. Identification of meibomian gland lipids by gas chromatogram phy mass spectrometry: Application to the meibomian lipids of the mouse. J Chromatogr. 1984;301: 173-187. doi: 10.1016/s0021-9673(01)89187-1.
  18. Hassing GS. Inhibition of Corynebacterium acnes lipase by tetracycline. J Invest Dermatol. 1971;56:189-192.
  19. Hill JC. Analysis of senile changes in the palpebral fissure. Trans. Ophthalmol Soc UK. 1975;95(pt 1):49.
  20. Hykin PG, Bron AJ. Age-related morphological changes in lid margin and meibomian gland anatomy. Cornea. 1992;11(4):334-342.
  21. Iyengar SS, Dresner SC. Entropion. Smith and Nesi’s Ophthalmic Plastic and Reconstructive Surgery. 3rd ed. New York: Springer; 2012:311-315.
  22. Jones LT. The anatomy of the lower eyelid, and its relation to the cause and cure of entropion. Am J Ophthalmol. 1960;49: 29-36.
  23. Jones LT, Reeh MJ, Tsujimura JK. Senile entropion. Am J Ophthalmol. 1963;55(3):463-469.
  24. Keith CG. Seborrhoeic blepharo-kerato-conjunctivitis. Trans Ophthalmol Soc UK. 1967;87:85-103.
  25. Michels KS, Czyz CN, Cahill KV, et al. Age-Matched, Case-Controlled Comparison of Clinical Indicators for Development of Entropion and Ectropion. J of Ophthalmol. 2014; Article ID 231487:7. doi: 10.1155/2014/231487.
  26. Mathers WD, Shields WJ, Sachdev MA, et al. Meibomian gland dysfunction in chronic blepharitis. Cornea. 1991;10(4):277-285. doi: 10.1097/00003226-199107000-00001.
  27. Mathers WD, Shields WJ, Sachdev MS, et al. Meibomian gland morphology and tear osmolarity: changes with Accutane therapy. Cornea. 1991;10(4):286-290. doi: 10.1097/00003226-199107000-00002.
  28. Mannis MJ, Holland EJ. Ocular surface disease. Medical and surgical management. New York : Springer; 2002.
  29. Marzouk MA, Shouman AA, Elzakzouk ES, et al. Lateral Tarsal strip technique for correction of lower eyelid Ectropion. J of Am Sci. 2011;7(5).
  30. Musch DC, Sugar A. Meyer RF. Demographic and predisposing factors in corneal ulceration. Arch Ophthalmol. 1983;101(10):1545-8. doi: 10.1001/archopht.1983.01040020547007.
  31. Nowinski TS. Entropion. In: Tse DT, editor. Color Atlas of Oculoplastic Surgery. 2nd ed. Philadelphia (PA): Lippincott Williams & Wilkins; 2011. P. 44-53.
  32. Piskiniene R. Eyelid malposition: lower lid entropion and ectropion Medicina (Kaunas). 2006;42(11):881-4.
  33. Scheie H, Albert DM. Distichiasis and trichiasis: origin and management. Am J Ophthalmol. 1966;61(4):718-720. doi: 10.1016/0002-9394(66)91209-8.
  34. Vallabhanath P, Carter SR. Ectropion and entropion. Curr Opin Ophthalmol. 2000 Oct;11(5):345-51.
  35. Yamaguchi M, Kutsuna M, Uno T, et al. Marx line: fluorescein staining line on the inner lid as indicator of meibomian glandfunction. Am J Ophthalmol. 2006;141(4):669-675. doi: 10.1016/j.ajo.2005.11.004.

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Copyright (c) 2016 Potemkin V.V., Rakhmanov V.V., Ageeva E.V., Alchinova A.S., Meshveliani E.V.

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