Diagnosis and therapy of bacterial vaginosis in pregnancy


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Abstract

Bacterial vaginosis (BV) is the most common vaginal disorder in women of reproductive age. This review presents literature data regarding a role of BV in adverse reproductive health outcomes, describes current methods used for BV diagnosis and issues of treatment of this disease in pregnant women.

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About the authors

Kira Valentinovna Shalepo

D. O. Ott Research Institute of Obstetrics and Gynecology RAMS

Email: 2474151@mail.ru
PhD, Senior Researcher, Laboratory of Microbiology

Veronika Viktorovna Nazarova

D. O. Ott Research Institute of Obstetrics and Gynecology RAMS

Email: Nazarova111@bk.ru
Bacteriologist, Laboratory of Microbiology

Yuliya Nikolayevna Menukhova

City Clinic N 32, Women’s Consultation N 14

Email: Yul-yul@list.ru
Head of Women’s Consultation N 14

Yelena Vasilyevna Shipitsyna

D. O. Ott Research Institute of Obstetrics and Gynecology RAMS

Email: shipitsyna@inbox.ru
PhD, Senior Researcher, Laboratory of Microbiology

Alevtina Mikhailovna Savicheva

D. O. Ott Research Institute of Obstetrics and Gynecology RAMS

Email: savitcheva@mail.ru
MD, PhD, Dr Med Sci, Professor, Head of the Laboratory of Microbiology

References

  1. Антоненко М. М., Казарова Г. В., Культенко Г. А. и др. Опыт применения метода прямой микроскопии на приеме врача акушера-гинеколога женской консультации родильного дома города Выборга Ленинградской области. Материалы международной конференции, 31 мая 2007, С.-Петербург. Охрана репродуктивного здоровья в рамках реализации национального проекта «Здоровье» // Журнал акушерства и женских болезней. - 2007. - Т. LVI. - С. 69-72.
  2. Европейские стандарты диагностики и лечения заболеваний, передающихся половым путем. - М.: Медицинская литература, 2004.
  3. Савельева Г. М., Серов В. Н., Сухих Г. Т. Акушерство и гинекология - клинические рекомендации. 3-е изд. - М.: 2011.
  4. Савичева А. М., Башмакова М. А., Красносельских Т. В. и др. Лабораторная диагностика бактериального вагиноза. - СПб.: Н-Л, 2011. - 25 с.
  5. Савичева А. М., Соколовский Е. В., Домейка М. Порядок проведения микроскопического исследования мазков из урогенитального тракта: Методические рекомендации для лечащих врачей. - СПб.: Н-Л, 2007. - 72 с.
  6. Шалепо К. В., Назарова В. В., Менухова Ю. Н. и др. Оценка современных методов лабораторной диагностики бактериального вагиноза // Журнал акушерства и женских болезней. - 2014. - Т. LVIII. - Вып. 1. - С. 26-32.
  7. Allsworth J. E., Peipert J. F. Severity of bacterial vaginosis and the risk of sexually transmitted infection // Am. J. Obstet. Gynecol. - 2011. - Vol. 205, N 2. - P. 113.e1-113.e6.
  8. Amsel R., Totten P. A., Spiegel C. A. et al. Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations // Am. J. Med. - 1983. - Vol. 74, N 1. - P. 14-22.
  9. Barry A. L., Thornsberry C., Jones R. N. In vitro activity of a new macrolide, A-56268, compared with that of roxithromycin, erythromycin, and clindamycin // Antimicrob. Agents Chemother. - 1987. - Vol. 31. - P. 343-345.
  10. Bennett B. B., Clark P., Riley P. et al. The association of asymptomatic bacterial vaginosis with upper genital tract infection // Prim. Care. Update. Ob. Gyns. - 1998. - Vol. 5, N 4. - P. 150.
  11. Bhattacharjee B., Herrington C. S., Sunderland D., Birley H. D. Scanning electron microscopy of endometrial biopsies of patients with bacterial vaginosis shows morphology resembling mycoplasma/ureaplasma organisms // Sex. Transm. Infect. - 1999. - Vol. 75. - P. 202.
  12. Cherpes T. L., Meyn L. A., Krohn M. A. et al. Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis // Clin. Infect. Dis. - 2003. - Vol. 37. - P. 319-325.
  13. De Backer E., Dubreuil L., Brauman M. et al. In vitro activity of secnidazole against Atopobium vaginae, an anaerobic pathogen involved in bacterial vaginosis // Clin. Microbiol. Infect. - 2010. - Vol. 16. - P. 470-472.
  14. De Backer E., Verhelst R., Verstraelen H. et al. Antibiotic susceptibility of Atopobium vaginae // BMC. Infect. Dis. - 2006. - Vol.6. - P. 51.
  15. Ferris M. J., Masztal A., Aldridge K. E. et al. Association of Atopobium vaginae, a recently described metronidazole resistant anaerobe, with bacterial vaginosis // BMC Infect. Dis. - 2004. - Vol. 13, N 4. - P. 5.
  16. Fredricks D. N., Fiedler T. L., Marrazzo J. M. Molecular identification of bacteria associated with bacterial vaginosis // N. Engl. J. Med. - 2005. - Vol. 353. - P. 1899-1911.
  17. Goldstein E. J., Citron D. M., Merriam C. V. et al. In vitro activities of Garenoxacin (BMS 284756) against 108 clinical isolates of Gardnerella vaginalis // Antimicrob. Agents. Chemother. - 2002. - Vol. 46. P. 3995-3996.
  18. Haggerty C. L., Hillier S. L., Bass D. C., Ness R. B. Bacterial vaginosis and anaerobic bacteria are associated with endometritis // Clin. Infect. Dis. - 2004. - Vol. 39. - P. 990-995.
  19. Hay P. E., Lamont R. F., Taylor-Robinson D. et al. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage // BMJ. - 1994. - Vol. 308. - P. 295-298.
  20. Hillier S. L., Kiviat N. B., Hawes S. E. et al. Role of bacterial vaginosis-associated microorganisms in endometritis // Am. J. Obstet. Gynecol. - 1996. - Vol. 175. - P. 435-441.
  21. Hillier S., Krohn M. A., Watts D. H. et al. Microbiologic efficacy of intravaginal clindamycin cream for the treatment of bacterial vaginosis // Obstet. Gynecol. - 1990. - Vol. 76. - P. 407-413.
  22. Hillier S. L., Martius J., Krohn M. et al. A case-control study of chorioamnionic infection and histologic chorioamnionitis in prematurity // N. Engl. J. Med. - 1988. - Vol. 319. - P. 972-978.
  23. Hillier S. L., Nugent R. P., Eschenbach D. A. et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group // N. Engl. J. Med. - 1995. - Vol. 333. - P. 1737-1742.
  24. Ison C. A., Hay P. E. Validation of a simplified grading of Gram stained vaginal smears for use in genitourinary medicine clinics // Sex. Transm. Infect. - 2002. - Vol. 78, N 6. - P. 413-415.
  25. Keelan J. A., Blumenstein M., Helliwell R. J. et al. Cytokines, prostaglandins and parturition-a review // Placenta. - 2003. - (24 suppl. A). - S33-S46.
  26. Khatamee M. A., Sommers S. C. Clinicopathologic diagnosis of mycoplasma endometritis // Int. J. Fertil. - 1989. - Vol. 34. - P. 52-55.
  27. Korn A. P., Bolan G., Padian N. et al. Plasma cell endometritis in women with symptomatic bacterial vaginosis // Obstet. Gynecol. - 1995. - Vol. 85. - P. 387-390
  28. Kurki T., Sivonen A., Renkonen O. V. et al. Bacterial vaginosis in early pregnancy and pregnancy outcome // Obstet. Gynecol. - 1992. - Vol. 80. - P. 173-177.
  29. Lamont R. F., Nhan-Chang C. L., Sobel J. D. et al. Treatment of abnormal vaginal flora in early pregnancy with clindamycin for the prevention of spontaneous preterm birth: a systematic review and metaanalysis // Am. J. Obstet. Gynecol. - 2011. - Vol. 205, N 3. - P. 177-190.
  30. Lamont R. F., Taylor-Robinson D., Newman M. et al. Spontaneous early preterm labour associated with abnormal genital bacterial colonization // Br. J. Obstet. Gynaecol. - 1986. - Vol. 93. - P. 804-810.
  31. Marrazzo J. M., Martin D. H., Watts D. H. et al. Bacterial vaginosis: identifying research gaps proceedings of a workshop sponsored by DHHS/NIH/NIAID // Sex. Transm. Dis. - 2010. - Vol. 37. - N. 12. - P. 734.
  32. Martius J., Eschenbach D. A. The role of bacterial vaginosis as a cause of amniotic fluid infection, chorioamnionitis and prematurity - a review // Arch. Gynecol. Obstet. - 1990. - Vol. 247. - P. 1-13.
  33. McFarland L. V. Antibiotic-associated diarrhea: epidemiology, trends and treatment // Future Microbiol. - 2008. - Vol. 3. - P. 563-578.
  34. McGregor J. A., French J. I., Jones W. et al. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: results of a controlled trial of topical clindamycin cream // Am. J. Obstet. Gynecol. - 1994. - Vol. 170. - P. 1048-1059.
  35. Miller A. M., Bassett M. L., Dahlstrom J. E., Doe W. F. Antibiotic-associated haemorrhagic colitis // J. Gastroenterol. Hepatol. - 1998. - Vol. 13. - P. 1115-1118.
  36. Mittal V., Jain A., Pradeep Y. Development of modified diagnostic criteria for bacterial vaginosis at peripheral health centres in developing countries // J. Infect. Dev. Ctries. - 2012. - Vol. 6, N 5. - P. 373-377.
  37. Myer L., Kuhn L., Stein Z. A. et al. Intravaginal practices, bacterial vaginosis, and women’s susceptibility to HIV infection: epidemiological evidence and biological mechanisms // Lancet. Infect. Dis. - 2005. - Vol. 5. - P. 786-794.
  38. Mylonakis E., Ryan E. T., Calderwood S. B. Clostridium difficile - associated diarrhea: a review // Arch. Intern. Med. - 2001. - Vol. 161. - P. 525-533.
  39. Nugent R. P., Krohn M. A., Hillier S. L. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation // J. Clin. Microbiol. - 1991. - Vol.29, N 2. - P. 297-301.
  40. Ralph S. G., Rutherford A. J., Wilson J. D. Influence of bacterial vaginosis on conception and miscarriage in the first trimester: cohort study // BMJ. - 1999. - Vol. 319. - P. 220-223.
  41. Schwebke J. R., Weiss H. L. Interrelationships of bacterial vaginosis and cervical inflammation // Sex. Transm. Dis. - 2002. - Vol. 29. - P. 59-64.
  42. Silver H. M., Sperling R. S., St Clair P. J., Gibbs R. S. Evidence relating bacterial vaginosis to intraamniotic infection // Am. J. Obstet. Gynecol. - 1989. - Vol. 161. - P. 808-812.
  43. Soper D. E. Clindamycin // Obstet. Gynecol. Clin. North. Am. - 1992. - Vol. 19. - P. 483-496.
  44. Spiegel C. A., Amsel R., Holmes К. K. Diagnosis of bacterial vaginosis by direct gram stain of vaginal fluid // J. Clin. Microbiol. - 1983. - Vol.18, N 1. - P. 170-177.
  45. Spiegel C. A. Bacterial vaginosis // Rev. Med. Microbiol. - 2002. - Vol. 13. - P. 43-51.
  46. Spiegel C. A., Eschenbach D. A., Amsel R., Holmes K. K. Curved anaerobic bacteria in bacterial (nonspecific) vaginosis and their response to antimicrobial therapy // J. Infect. Dis. - 1983. - Vol. 148. - P. 817-822.
  47. Spiegel C. A. Susceptibility of Mobiluncus species to 23 antimicrobial agents and 15 other compounds // Antimicrob. Agents. Chemother. - 1987. - Vol. 31. - P. 249-252.
  48. Sweet R. L. Role of bacterial vaginosis in pelvic inflammatory disease // Clin. Infect. Dis. - 1995. - Vol. 20 (Suppl. 2). - P. 271-275.
  49. Verhelst R., Verstraelen H., Claeys G. et al. Cloning of 16S rRNA genes amplified from normal and disturbed vaginal microflora suggests a strong association between Atopobium vaginae, Gardnerella vaginalis and bacterial vaginosis // BMC Microbiol. 2004. - Vol. 4. - P. 16.
  50. Verstraelen H., Verhelst R., Claeys G. et al. Culture-independent analysis of vaginal microflora: the unrecognized association of Atopobium vaginae with bacterial vaginosis // Am. J. Obstet. Gynecol. - 2004. - Vol. 191. - P. 1130-1132.
  51. Watts D. H., Krohn M. A., Hillier S. L., Eschenbach D. A. Bacterial vaginosis as a risk factor for post-cesarean endometritis // Obstet. Gynecol. - 1990. - Vol. 75. - P. 52-58.
  52. Wiesenfeld H. C., Hillier S. L., Krohn M. A. et al. Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection // Clin. Infect. Dis. - 2003. - Vol. 36. - P. 663-668.
  53. Wiesenfeld H., Hillier S., Krohn M. et al. Lower genital tract infection and endometritis: Insight into subclinical pelvic inflammatory disease // Obstet. Gynecol. - 2002. - Vol. 100. - P. 456-463.
  54. Workowski K. A., Berman S. Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2010 // MMWR Recomm Rep. - 2010. - Vol. 59. - P. 1-110.
  55. Xiao J. C., Xie L. F., Fang S. L. et al. Symbiosis of Mycoplasma hominis in Trichomonas vaginalis may link metronidazole resistance in vitro // Parasitol. Res. - 2006. - Vol. 100. - P. 123-130.
  56. Zambrano D. Clindamycin in the treatment of obstetric and gynecologic infections: a review // Clin. Ther. - 1991. - Vol. 13. - P. 58-80.
  57. Zozaya-Hinchliffe M., Martin D. H., Ferris M. J. Prevalence and abundance of uncultivated Megasphaera-like bacteria in the human vaginal environment // Appl. Environ. Microbiol. - 2008. - Vol. 74. - P. 1656-1359.

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Copyright (c) 2014 Shalepo K.V., Nazarova V.V., Menukhova Y.N., Shipitsyna Y.V., Savicheva A.M.

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