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Clinical implication of the Hydrogen Breath Test for diagnosis of lactose intolerance and overgrows syndrome in infants
- Authors: Korniyenko Y.A.1, Kubalova S.S.1, Dmitriyenko M.A.2, Dzhagatspanyan I.E.2
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Affiliations:
- Saint-Petersburg State Pediatric Medical University
- Association of Medicine and Analytics
- Issue: Vol 4, No 1 (2013)
- Pages: 9-15
- Section: Articles
- URL: https://journals.eco-vector.com/pediatr/article/view/1178
- DOI: https://doi.org/10.17816/PED419-15
- ID: 1178
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Abstract
The aim of this study was to estimate the diagnostic value of the Hydrogen Breath Test (HBT) in diagnosis of lactose intolerance (LI) and overgrows syndrome (OS) in infants with functional gastrointestinal disorders (FGD). 102 infants from 1 to 6 months with FGD symptoms were investigated by HBT with lactose, fecal microbiota were examined by culture and real time PCR, fecal calprotectin was measured. LI was found in 37 % FGD infants, OS in 60 %. Calprotectin level was 445 ± 28 mg/g in OS and 195 ± 27 mg/g in infants without OS. Microbiota was altered in all FGD infants with increase of Cl. difficile, St. aureus. Infants with LI got Lactase Baby, infants with OS-L. reuteri in infant formula NAN Comfort or in drops Rela Life. Both were effective in elimination of FGD symptoms. Calprotectin level and microbiota disturbances were better after treatment.
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About the authors
Yelena Aleksandrovna Korniyenko
Saint-Petersburg State Pediatric Medical University
Email: elenkornienk@yandex.ru
MD, Prof., Head of the Gastroenterology Department, Faculty of Postgraduate Education
Saida Sultanovna Kubalova
Saint-Petersburg State Pediatric Medical University
Email: saidakubalova@mail.ru
Postgraduate Student, Gastroenterology Department, Faculty of Postgraduate Education
Marina Aleksandrovna Dmitriyenko
Association of Medicine and Analytics
Email: mari_alexa@mail.ru
PhD, General Director
Igor Eduardovich Dzhagatspanyan
Association of Medicine and Analytics
Email: drjie@mail.ru
PhD, Director of the Development Department
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