Role of modified ultrafiltration in reduce of the systemic inflammatory response syndrome in cardiac surgery


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Abstract

During open-heart surgery it is possible to disturbance of the barrier function and the appearance of inflammation in the systemic circulation of inflammatory mediators and pro-inflammatory cytokines, which is realized in the systemic inflammatory response syndrome (SIRS). To prevent the development of the condition, or to reduce the severity of its complications method of mechanical removal of inflammatory mediators and cytokines from the blood of the patient is the most efficient. At the moment, the problem of implementation of the systemic inflammatory response syndrome after surgery using cardiopulmonary bypass quite relevant because of the high frequency of its manifestations and adverse effects [18]. This explains the large number of studies aimed at both the study of the pathogenesis of systemic inflammatory response syndrome and the development of new methods to combat this phenomenon and the improvement of already applied methods and techniques [1, 4]. There are various ways to the reduction of the degree of systemic inflammatory response syndrome, but special attention is given to the study of methods of modified ultrafiltration and continuous veno-venous hemofiltration. Further study of the application of ultrafiltration on patients undergoing cardiac surgery heart surgery with the use of bypass is necessary for understanding of the physiology and pathophysiology of systemic inflammatory response syndrome induced by the conduct of bypass, as well as for the subsequent formulation of clinical guidelines for use in cardiac surgery practice. In this article we have tried to consider the most significant results of such studies.

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About the authors

Gennadiy G Khubulava

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: sergeimarchenkospb@gmail.com
MD, PhD, Dr Med Sci, Professor, Head of the Department of Cardiovascular Surgery. St. Petersburg State Pediatric Medical University.

Sergey P Marchenko

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: sergeimarchenkospb@gmail.com
MD, PhD, Dr Med Sci, Professor, Department of Cardiovascular Surgery. St. Petersburg State Pediatric Medical University.

Ekaterina V Dubova

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: katrin@dr.com
Resident doctor, Department of Hospital Pediatrics. St. Petersburg State Pediatric Medical University.

Vitaliy V Suvorov

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: vitalikkrak@gmail.com
Assistant Professor, Department of Cardiovascular Surgery. St. Petersburg State Pediatric Medical University.

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Copyright (c) 2016 Khubulava G.G., Marchenko S.P., Dubova E.V., Suvorov V.V.

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