Pathogenic Variants of Urolithiasis

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Abstract


The essence of Urolithiasis - one of the oldest diseases known by the mankind - is still not understood completely. For a long time the comprehension of Urolithiasis was based on matrix, colloid, ionic, inhibitory and precipitation theories. In these cases it was impossible to single out separate pathogenetic patterns. Besides, in spite of the absence of in vivo proofs the fact that new concrement nucleus forming (de novo nucleation) is only possible outside of the stone-forming metastability range should be taken into consideration for metaphilactic purposes. Fortunately, certain progress in understanding Urolithiasis started with the onset of studies devoted to detailed scrutiny of stone-forming patients’ metabolic peculiarities as well as with the introduction into clinical practice of the up-to-date digital endoscopes. Based on existing publications one may classify pathogenesis of stone-forming into 4 major groups: growth of calcium-oxalic stones on Randall’s plaques in patients with hypercalciumuria; excrescences on the of Belliny’s ducts’ “gags”; microlites forming within the internal medullar layer discharging tubules’ lumen in patients with cystineuria; stones forming in free solution. There is no doubt this classification is not the final one, neither does it exclude mixed variants, however better understanding of the aforementioned pathogenic variants would facilitate a novel view at Urolithiasis and in patients with kidney stones would increase anti-relapse measures’ effectiveness.

Petr S Baketin

Principal contact for editorial correspondence.
pyotr-baketin@yandex.ru
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine
Russian Federation

urologist, Department of Urology

Rashid A Mollaev

r_mollaev@mail.ru
Askerkhanov Central municipal hospital
Russian Federation

urologist

Denis A Mazurenko

d.a.mazurenko@gmail.com
Urologic Clinic. EMC
Russian Federation

urologist, MD, PhD. Vice Director

Vladislav E Grigoryev

vladislav.grigorev@outlook.com
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine
Russian Federation

urologist, Department of Urology

Nariman K Gadzhiev

nariman.gadjiev@gmail.com
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine
Russian Federation

urologist, Department of Urology

Vladimir M Obidnyak

v.obidniak@gmail.com
St Petersburg St Luka Clinical Hospital
Russian Federation

MD, urologist. Department of Urology

Alexey V Pisarev

alexey.v.pisarev@gmail.com
St Petersburg Multiprofile Center
Russian Federation

MD, urologist. Department of Urology

Nair S Tagirov

ruslana73nair@mail.ru
St Petersburg St Elisabeth City Hospital
Russian Federation

MD, PhD, urologist

Vigen A Malkhasyan

vigenmalkhasyan@gmail.com
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Russian Federation

Assistant, Department of Urology

Sergey B Petrov

petrov-uro@yandex.ru
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine
Russian Federation

urologist, MD, Professor. Head of department of Urology

Sergei V Popov

doc.popov@gmail.com
A.M. Nikiforov Russian Center of Emergency and Radiation Medicine
Russian Federation

MD, PhD, Dr Med Sci, Head Doctor

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Copyright (c) 2017 Baketin P.S., Mollaev R.A., Mazurenko D.A., Grigoryev V.E., Gadzhiev N.K., Obidnyak V.M., Pisarev A.V., Tagirov N.S., Malkhasyan V.A., Petrov S.B., Popov S.V.

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