Risk factors of progression of chronic kidney disease in children with congenital malformations of the urinary tract in the postoperative period

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Abstract


The aim of the study is the identification of independent predictors of progression of chronic kidney disease (CKD) in children operated on for congenital malformations of the urinary tract (CMUT).

Methods. Study design – retrospective, observational, cohort. Inclusion criteria were CMUT, glomerular filtration rate (GFR) <90 ml/min/1.73 m2. Age younger than 18 years of age. The study included 297 patients. Statistical processing of research results was carried out using the software package Statistica 6.0. and MedCalc (MedCalc Software, Belgium).

Results. We identified that only glomerular filtration rate during the initial hospitalization (ОR = 9.40) and arterial hypertension (OR = 4.40) were independent predictors of CKD progression. The combination of these two variant showed the area under the ROC curve (0.756), significantly (p < 0.005) higher than the isolated value of these symptoms.


Rustem Z Ahmetshin

Author for correspondence.
rz47@rambler.ru
Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Ufa, Russia

PhD, chief of the Department of Pediatrics IDPO

I Lutfarahmanov Ildar

orit@mail333.com
Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Ufa, Russia

D.Med.Sc., Professor, Chief of the Department of Anesthesiology and Intensive Care

Ivanovich Mironov Petr

mironovpi@mail.ru
Bashkortostan State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Ufa, Russia

D.Med.Sc., Professor of the Department of Pediatric Surgery

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