Use of Kanefron in treatment of acute uncomplicated cystitis in women

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Abstract

The aim of study was to evaluate the efficacy and safety of Kanefron with uncomplicated cystitis in women in clinical practice. Patients and methods. In our work was attended by 22 women with a diagnosis of acute uncomplicated cystitis. The mean age was 29,0 ± 1,8 years (from 19 to 51 years. The criteria of effectiveness were changes in symptoms and laboratory parameters according to the urinary tests at Kanefron monotherapy. Results. After treating by Kanefron there were observed significant improvement in symptoms of acute cystitis. Before treatment the average symptom score was 8,05 ± 0,7 points, on the 3rd day of treatment it significantly decreased to 5,1 ± 1,0 points (p < 0,05) on day 7 of treatment it was up to 2, 9 ± 1,0 points, in the phase of observation of 37 days after initiation of therapy by Kanefron othe average score of symptoms was 0,1 ± 0,3 points. Frequency leukocyturia on the 7 day of treatment according to a study by urine microscopy was 83.3%, and by the 37 th day after the start of Kanefron (phase monitoring) significantly decreased to 37,5% (p < 0,05). Kanefron showed statistically significant antibacterial activity in acute cystitis. Prior to initiating therapy the growth of microorganisms at a titer of more than 100 000 units was detected in 72.7% of patients after 2 weeks of treatment (on day 37 of observation) - in 28,6% of patients (p < 0,05). Conclusions. Our results suggest that Kanefron can be an effective and well-tolerated alternative treatment of uncomplicated infections of the lower urinary tract in women, allowing to reduce the use of antibiotics. Appointment of the drug as a monotherapy Kanefron acute cystitis and duration of treatment requires further study and discussion.

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About the authors

Refat E Amdii

First State Pavlov Medical University of St Petersburg

Email: R.E.Amdiy@mail.ru
doctor of medical science, professor. Department of Urology

Salman H Al-Shukri

First State Pavlov Medical University of St Petersburg

Email: al-shukri@mail.ru
doctor of medical science, professor, head of the department. Department of Urology

Igor V Kuzmin

First State Pavlov Medical University of St Petersburg

Email: kuzminigor@mail.ru
doctor of medical science, professor. Department of Urology

Nikolay V Sorokin

Center Outpatient Urology and Andrology

Email: nika_sorokin@mail.ru
candidate of medical sciences, urologist, head of the Center

Evgeniy A Chaplitskii

Center Outpatient Urology and Andrology

Email: evgeniychap@gmail.com
urologist

Mikhail V Skvortsov

Center Outpatient Urology and Andrology

Email: skv.81@mail.ru
urologist

Aleksander S Alekseev

city policlinic No 107

Email: aleksandr.alekseev.63@mail.ru
urologist

Abubakar S Okunchayev

city policlinic No 107

urologist

Aleksey A Turbin

сity policlinics No 17

Email: leshman@list.ru
therapist

Gulnara R Timaeva

сity policlinics No 11

therapist

Dmitriy V Bulaev

city policlinics No 99

Email: urolog.bulaev@mail.ru
urologist

Yuliya S Moscaleva

First State Pavlov Medical University of St Petersburg

Email: narayana-kalman@mail.ru
Urology Department

References

  1. Little P, Moore MV, Turner S, et al. Effectiveness of five different approaches in management of urinary tract infection: randomised controlled trial. BMJ. 2010;340:199-204. doi: 10.1136/bmj.c199.
  2. Ivanov D, Abramov-Sommariva D, Moritz К, et al. An open label, non-controlled, multicentre, interventional trial to investigate the safety and efficacy of Canephron® N in the managementof uncomplicated urinary tract infections (uUTIs). Clinical Phytoscience. 2015;1(7):1-11. doi: 10.1186/s40816-015-0008-x.
  3. Wagenlehner FM, Weidner W, Naber KG. An update on uncomplicated urinary tract infections in women. Current Opinion in Urology. 2009;19:368-374. doi: 10.1097/mou.0b013e32832ae18c.
  4. Ferry SA, Holm SE, Stenlund H, et al. The natural course of uncomplicated lower urinary tract infection in women illustrated by a randomized placebo controlled study. Scand J Inf Dis. 2004;36:296-301. doi: 10.1080/00365540410019642.
  5. Naber KG. Efficacy and safety of the phytotherapeutic drug Canephron® N in prevention and treatment of urogenital and gestational disease: review of clinical experience in eastern europe and central asia. Research and reports in Urology. 2013;5:39-46. doi: 10.2147/rru.s39288.

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Copyright (c) 2016 Amdii R.E., Al-Shukri S.H., Kuzmin I.V., Sorokin N.V., Chaplitskii E.A., Skvortsov M.V., Alekseev A.S., Okunchayev A.S., Turbin A.A., Timaeva G.R., Bulaev D.V., Moscaleva Y.S.

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