Clinical efficacy of agonist toll-like receptor 9 on the process of reparations after loop conization (LEEP) of the cervix

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Abstract

The aim of this study to explore the use of the agonist Toll-like receptors 9 (TLR 9) in the postoperative period after the LEEP, performed for cervical intraepithelial neoplasia, influences the process tissue repair cervix.

Materials and methods. In a randomized, longitudinal, prospective, comparative study included 70 patients with squamous intraepithelial lesions (HSIL и LSIL). Patients first test group (n = 36) was obtained postoperatively as a TLR agonist Derinat 9 immunomodulator. Two patients, the control group (n = 34), postoperative not administered any medication drugs. In the process of diagnosis all patients were performed conventional cytology and colposcopy, PCR-test for human papillomavirus (HPV). These parameters were examined postoperatively at 1 month and 6 months.

Results. Systemic administration agonist TLR 9, drug Derinat in clean postoperative wound of the cervix pathogenetically justified because it, together with the alteration leads to a synergistic effect to the reparative function of the macrophages through activation of Toll-like receptors 9 and the subsequent synthesis of cytokines directly accelerates the process of repair and immune supervision of malignant transformation cervical intraepithelial neoplasia tissues.

Conclusion. Patients after LEEP is recommended the appointment of the drug Derinat, agonist of toll-like receptor 9, immunomodulator with the reparative effect, intramuscular injection of 15 mg/mL, 75 mg after 24 hours number 10.

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На сегодняшний день рак шейки матки (РШМ), несмотря на обстоятельно разработанные и достаточно широко внедренные скринин

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About the authors

Nikolay N Minaev

Voronezh State Medical University named after NN Burdenko

Author for correspondence.
Email: mnn@vmail.ru
PhD, MD, professor, Head of the Department of Obstetrics and Gynecology. The Institute of Advanced Training Russian Federation

Marina N Ivanova

Voronezh Regional Clinical Oncology Center

Email: mnn@vmail.ru
PhD, gynecologist Russian Federation

Daniil Ju Bugrimov

Voronezh State Medical University named after NN Burdenko

Email: danikst@mail.ru
PhD, advisor RAE master MANEB, Senior Researcher, Associate Professor, Department of Pathological Anatomy Russian Federation

Andrey A Klimovich

Voronezh State Medical University named after NN Burdenko

Email: klimovich@gmail.com
Researcher of the Institute of Experimental Biology and Medicine (EBM Research Institute) Russian Federation

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Copyright (c) 2016 Minaev N.N., Ivanova M.N., Bugrimov D.J., Klimovich A.A.

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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия Эл № 77 - 6389 от 15.07.2002 г.


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