Association of FGB, LPL, GPIIIA and TGFB gene polymorphisms with variants of atherosclerosis severity
- Authors: Garaeva LA1, Mayanskaya SD1
-
Affiliations:
- Kazan State Medical University
- Issue: Vol 98, No 5 (2017)
- Pages: 669-674
- Section: Theoretical and clinical medicine
- URL: https://kazanmedjournal.ru/kazanmedj/article/view/7013
- DOI: https://doi.org/10.17750/KMJ2017-669
- ID: 7013
Cite item
Full Text
Abstract
Aim. To estimate the effect of transforming growth factor в, lipoprotein lipase, fibrinogen в and glycoprotein 3б gene polymorphisms on different variants of atherosclerosis severity.
Methods. The study included 319 patients with angiografically verified atherosclerosis. In all patients FGB (rs1800788), LPL (rs328), GpIIIa (rs5918) and TGFВ (rs1800469) polymorphism genotyping was performed. In all patients we evaluated the influence of the studied gene polymorphisms on parameters of atherosclerosis severity such as occlusion and presence and severity of stenosis. Presence of occlusion, occlusion and/or two and more stenoses over 70%, occlusion and multiple critical stenoses were considered the severity criteria.
Results. The studied gene polymorphisms were shown to be associated with severe course of atherosclerosis. GPIIIa polymorphism was commonly determined in patients with more severe course regardless of occlusion and number and severity of stenoses. FGB gene influenced the rate of occlusion development, TGF gene was expressed only in the group with occlusion and/or two and more stenoses over 70%, and LPL gene proved to be significant for the development of occlusion associated with critical stenosis.
Conclusion. The frequency of rare alleles of polymorphic regions is significantly associated with different variants of severe atherosclerosis course; this could suggest unequal influence of gene polymorphisms as well as their proteins on different stages of atherogenesis and requires further investigation.
About the authors
L A Garaeva
Kazan State Medical University
Author for correspondence.
Email: garaevalily@gmail.com
Kazan, Russia
S D Mayanskaya
Kazan State Medical University
Email: garaevalily@gmail.com
Kazan, Russia
References
- Hasdai D., Gibbons R.J., Holmes D.R.Jr. et al. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. Circulation. 1997; 96: 3390-3395. doi: 10.1161/01.CIR.96.10.3390.
- Baliga R., Rampling M.W., Kooner J.S. High fat meal induces changes in blood rheology in patients with coronary artery disease. Circulation. 1997; 96 (suppl. I): I-2206.
- Arca M., Campagna F., Montali A. et al. The common mutations in the lipoprotein lipase gene in Italy: effects on plasma lipids and angiographically assessed coronary atherosclerosis. Clin. Genetics. 2000; 58: 369-374. doi: 10.1034/j.1399-0004.2000.580507.x.
- Goldberg I.J. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J. Lipid Res. 1996; 36: 693-707. PMID: 8732771.
- Khatami M., Heidari M.M. Common rs5918 (PlA1/A2) polymorphism in the ITGB3 gene and risk of coronary artery disease. Arch. Med. Sci. Atherosclerotic Dis. 2016; 1: 9-15. doi: 10.5114/amsad.2016.59587.
- Yakushkin V.V., Zyuryaev I.T., Khaspekova S.G. et al. Glycoprotein IIb-IIIa content and platelet aggregation in healthy volunteers and patients with acute coronary syndrome. Platelets. 2011; 22: 243-251. doi: 10.3109/09537104.2010.547959.
- Papageorgiou N., Tousoulis D., Siasos G. Is fibrinogen a marker of inflammation in coronary artery disease? Hellenic J. Cardiol. 2010; 51: 1-9. PMID: 20118037.
- Behague I., Poirier O., Nicaud V., Evans A. β Fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. Circulation. 1996; 93: 440-449. doi: 10.1161/01.CIR.93.3.440.
- Syrris P., Carter N.D., Metcalfe J.C. et al. Transforming growth factor-beta1 gene polymorphisms and coronary artery disease. Clin. Sci. (London). 2005; 95 (6): 659-667. doi: 10.1042/cs0950659.
- Wang X.L., Sim A.S., Wilcken D.E.L. A common polymorphism of the transforming. Clin. Sci. 1998; 95: 745-746. doi: 10.1042/cs0950745.
- Border W.A., Noble N.A. Transforming growth factor beta in tissue fibrosis. New Engl. J. Med. 1994; 331 (19): 1286-1292. doi: 10.1056/NEJM199411103311907.
- Bolognese L.B. Changing patterns of ST elevation myocardial infarction epidemiology. Am. Heart J. 2010; 160: 1-3. doi: 10.1016/j.ahj.2010.10.008.
- Preuss M., Konig I.R., Thompson J.R. et al. Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: a genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. Cardiovasc. Genet. 2010; 3: 475-483. doi: 10.1161/CIRCGENETICS.109.899443.
Supplementary files
