Current conception of carotid chemodectoma and efficiency of its treatment methods

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Abstract


The review presents current data from foreign studies of a rare tumor — carotid chemodectoma, particularly, about its prevalence, classification, clinical presentation, applicability of different diagnostics methods, and also on efficiency of treatment of this disease and complications developing after it in terms of described clinical cases. Search for relevant sources was carried out in Medline, US National Library of Medicine, Elibrary systems, in Cochrane Library and peer-reviewed scientific journals. A total of 26 studies were found, 22 of them were included in the review. Carotid chemodectoma is most often characterized by benign course, but, because of its scarce clinical presentation, specific examination methods are required for its accurate diagnosis. Surgical resection is usually used for the treatment of carotid chemodectoma, and in case of contraindications for the surgery, radiotherapy is applied (as a palliative method). The most widespread complications after surgical treatment are cranial nerve damage, intraoperative bleeding and ischemic stroke. Several cases were described in literature, when scientists from different countries (USA, Korea) attempted to decrease risk of complications by use of preoperational embolization, but that led to new complications, particularly, to migration of embolic material. At the same time, scientists from Netherlands noted some decrease of the number of postoperative complications when craniocaudal method was used. To date the only effective method of treatment of carotid chemodectoma is still surgical resection, but it cannot be used in a broad variety of cases. Moreover, the world surgical practice has no effective techniques for prevention of different complications occurring in postoperative period, that reduces possibilities of successful patients’ recovery. Therefore, to decrease the rate of postoperative complications and to increase patients survival rate further studies are required.


Ju S Alferova

Author for correspondence.
AlferovaYuS@yandex.ru
I.M. Sechenov First Moscow State Medical University Moscow, Russia

V D Surina

AlferovaYuS@yandex.ru
I.M. Sechenov First Moscow State Medical University Moscow, Russia

N V Karpov

AlferovaYuS@yandex.ru
I.M. Sechenov First Moscow State Medical University Moscow, Russia

  • Paridaans M.P.M., van der Bogt K.E.A., Jansen J.C. et al. Results from craniocaudal carotid body tumor resection: Should it be the standard surgical approach? Eur. J. Vasc. Endovasc. Surg. 2013; 46 (6): 624-629. doi: 10.1016/j.ejvs.2013.08.010.
  • Amato B., Bianco T., Compagna R. et al. Surgical resection of carotid body paragangliomas: 10 years of experience. Am. J. Surg. 2014; 207 (2): 293-298. doi: 10.1016/j.amjsurg.2013.06.002.
  • Bishop G.B., Urist M.M., Gammal T. et al. Paragangliomas of the neck. Arch. Surg. 1992; 127: 1441-1445. doi: 10.1001/archsurg.1992.01420120075014.
  • Luo T., Zhang C., Ning Y.C. et al. Surgical treatment of carotid body tumor: Case report and literature review. J. Geriatr. Cardiol. 2013; 10: 116-118. doi: 10.3969/j.issn.1671-5411.2013.01.018.
  • Bakoyiannis K.C., Georgopoulos S.E., Klonaris C.N. et al. Surgical treatment of carotid body tumors without embolization. Int. Angiol. 2006; 25 (1): 40-45. PMID: 16520723.
  • Wang S.J., Wang M.B., Barauskas T.M., Calcaterra T.C. Surgical management of carotid body tumors. Otolaryngol. Head Neck Surg. 2000; 123 (3): 202-206. doi: 10.1067/mhn.2000.106709.
  • Barnes L., Tse L.L.Y., Hunt J.L. Carotid body paragangliomas. In: Pathology and genetics of head and neck tumors. Ed. by Barnes E.L., Evenson J.W., Reichardt P., Sidransky D. Lyon, France: IARC Press. 2005; 364-365.
  • Pryse-Davies J., Dawson I.P., Westbury G. Some morphological, histochemical, and chemical observations on chemodectomas and the normal carotid body, including a study of the chromaffin reaction and possible ganglion cell elements. Cancer. 1964; 17: 185-202. doi: 10.1002/1097-0142(196402)17:2<185::AID-CNCR2820170208>3.0.CO;2-1.
  • Kotelis D., Rizos T., Geisbusch P. et al. Late outcome after surgical management of carotid body tumors from a 20-year single center experience. Langenbecks Arch. Surg. 2009; 394 (2): 339-344. doi: 10.1007/s00423-008-0378-3.
  • Jani P., Qureshi A.A., Verma S., Walker L. Familial carotid body tumours: is there a role for genetic screening? J. Laryngol. Otol. 2008; 122 (9): 978-982. doi: 10.1017/S0022215107000023.
  • Miselli A., Bresciani P., Soana G. et al. Carotid glomus tumors. Study of 2 cases using color Duplex ultrasonography. Radiol. Med. 1994; 88: 877-880. PMID: 7878253.
  • Carriero A., Tonni A.G., D’Ettorre L. et al. Neoplasms of the glomus caroticum: magnetic resonance angiography versus magnetic resonance. Radiol. Med. 1994; 87: 71-75. PMID: 8128036.
  • Kwekkeboom D.J., van Urk H., Pauw B.K. et al. Osteroid scintigraphy for detection of paragangliomas. J. Nucl. Med. 1993; 34: 873-878. PMID: 8389841.
  • Shamblin W.R., Remine W.H., Sheps S.G., Harrison H.G. Carotid body tumor (chemodectoma): clinicopathologic analysis of 90 cases. Am. J. Surg. 1971; 122: 732-739. PMID: 5127724.
  • Berk M. Carotid body tumours with case presentation and angiographic demonstration. S. Afr. Med. J. 1959; 33 (16): 329-333. PMID: 13659135.
  • Ghoreishi M., Akbar-Beigi A., Tahery D., Sehhat S. Fever as the main presenting symptom of a carotid body tumor. Arch. Iran Med. 2008; 11 (2): 214-217. PMID: 18298303.
  • Knight T.T.Jr., Gonzalez J.A., Ray J.M., Rush D.S. Current concepts for the surgical management of carotid body tumor. Am. J. Surg. 2006; 191: 104-110. doi: 10.1016/j.amjsurg.2005.10.010.
  • Carroll W., Stenson K., Stringer S. Malignant carotid body tumor. Head Neck. 2004; 26 (3): 301-306. doi: 10.1002/hed.20017.
  • Zabel A., Milker-Zabel S., Huber P. et al. Fractionated stereotactic conformal radiotherapy in the management of large chemodectomas of the skull base. Int. J. Radiat. Oncol. Biol. Phys. 2004; 58: 1445-1450. doi: 10.1016/j.ijrobp.2003.09.070.
  • Shah H.M., Gemmete J.J., Chaudhary N. et al. Preliminary experience with the percutaneous embolization of paragangliomas at the carotid bifurcation using only ethylene vinyl alcohol copolymer (EVOH) Onyx. J. Neurointerv. Surg. 2012; 4 (2): 125-129. doi: 10.1136/jnis.2010.003970.
  • Lim J.-Y., Kim J., Kim S.H. et al. Surgical treatment of carotid body paragangliomas: Outcomes and complications according to the Shamblin classification. Clin. Exp. Otorhinolaryngol. 2010; 3 (2): 91-95. doi: 10.3342/ceo.2010.3.2.91.
  • Van der Bogt K.E., Vrancken Peeters M.P., van Baalen J.M., Hamming J.F. Resection of carotid body tumors: results of an evolving surgical technique. Ann. Surg. 2008; 247 (5): 877-884. doi: 10.1097/SLA.0b013e3181656cc0.

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