Immunoglobulin A and its selective deficiency

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Abstract


Immunoglobulin A plays a key role in local immunity preventing microorganism adhesion and its activity. Besides, it participates in virus and antigenes neutralizing. In the blood Immunoglobulin A circulates predominantly as a monomer, and at secretion as dimer in complex with S-component. Transitory decrease of Immunoglobulin A develops in different states: infectious and inflammatory processes, allergies, tumors. Specific disease is selective Immunoglobulin A deficiency which is a primary immunodeficiency. It is considered the most prevalent primary immunodeficiency but its true prevalence is unknown as in most cases it is asymptomatic and is revealed accidentally at laboratory testing. No specific methods of treatment of selective Immunoglobulin A deficiency exist. The literature review contains data on the character of the pathology, clinical presentation and tactics of patient management.


O V Moskalets

Author for correspondence.
6816000@mail.ru
Moscow Regional Research and Clinical Institute named after M.F. Vladimirskiy Moscow, Russia

  • Щербина А.Ю., Продеус А.П., Румянцев А.Г. Иммунодефицитные состояния. Трудный пациент. 2007; 5 (2): 5-10.
  • Кондратенко И.В., Бологов А.А. Первичные иммунодефициты. М.: Медпрактика-М. 2005; 233 с.
  • Kerr M.A. The structure and function of human IgA. Biochem. J. 1990; 271 (2): 285-296. doi: 10.1042/bj2710285.
  • Ярилин А.А. Основы иммунологии. Учебник. М.: Медицина. 1999; 608 с.
  • Jarvis G.A., Griffis J.M. Human IgA1 initiates complement-mediated killing of Neisseria meningitides. J. Immunol. 1989; 143 (5): 1703-1709. PMID: 2474610.
  • Бочарова К.А. Диагностика и лечение первичного иммунодефицитного состояния: селективный дефицит иммуноглобулина А. Науч. ведомости Белгородского гос. ун-та. Серия Медицина. Фармация. 2012; 17 (4): 259-265.
  • Moise A., Nedelcu F.D., Toader M.A. et al. Primary immunodeficiencies of the B lymphocyte. J. Med. Life. 2010; 3 (1): 60-63. PMID: 20302197.
  • Geha R.S., Notarangelo L.D., Casanova J.L. et al. Primary immunodeficiency diseases: an update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee. J. Allergy Clin. Immunol. 2007; 120: 776-794. doi: 10.1016/j.jaci.2007.08.053.
  • Pereira L.F., Sapina A.M., Arroyo J. et al. Prevalence of selective IgA deficiency in Spain: more than we thought. Blood. 1997; 90 (2): 893. PMID: 9226194.
  • Driessen G., Van der Burg M. Educational paper. Primary antibody deficiency. Eur. J. Pediatr. 2011; 170 (6): 693-702. doi: 10.1007/s00431-011-1474-x.
  • Выхристенко Л.Р., Янченко В.В., Новиков Д.К. Клиническое значение дефицитов иммуноглобулинов у взрослых. Международ. обзоры: клин. практика и здоровье. 2013; 5 (5): 21-31.
  • Carniero-Sampaio M.M., Carbonare S.B., Rozentraub R.B. et al. Frequency of selective IgA immunodeficiency among Brazilian blood donors and healthy pregnant women. Allergol. Immiunopathol. (Madr.). 1989; 17 (4): 213-216. PMID: 2816663.
  • Feng L. Epidemiological study of selective IgA deficiency among 6 nationalities in China. Zhonghua Yi Xue Za Zhi. 1992; 72 (2): 88-90, 128. PMID: 1327440.
  • Wang N., Lu P., Zhu Z., Hammarstrӧm L. Caucasian origin of disease associated HLA haplotypes in chinese blood donors with IgA immunodeficiency. J. Clin. Immunol. 2014; 34 (2): 154-62. DOI:10.1007/s 10875-013-9983-1.
  • Kanoh T., Mizumoto T., Yasuda N. et al. Selective IgA deficiency in Japanese blood donors: frequency and statistical analysis. Vox Sang. 1986; 50 (2): 81-86. doi: 10.1111/j.1423-0410.1986.tb04851.x.
  • Hammarstrӧm L., Vorechovsky I., Webster D. Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID). Clin. Expirement. Immunol. 2000; 120 (2): 225-231. doi: 10.1046/j.1365-2249.2000.01131.x.
  • Yel L. Selective IgA deficiency. J. Clin. Immunol. 2010; 30 (1): 10-16. doi: 10.1007/s10875-009-9357-x.
  • Mohammadi J., Ramanujam R., Jarefors S. et al. IgA deficiency and the MHC: assessment of relative risk and microheterogeneity within the HLA A1, B8, DR3 (8,1) haplotype. J. Clin. Immunol. 2010; 30 (1): 138-143. doi: 10.1007/s10875-009-9336-2.
  • Wang N., Hammarstrӧm L. IgA deficiency: what is new? Curr. Opin. Allergy Clin. Immunol. 2012; 12 (6): 602-608. DOI: 10/1097/ACL0b013e3283594219.
  • Yazdani R., Fatholahi M., Ganjalikhani-Hakemi M. et al. Role of apoptosis in common variable immunodeficiency and selective Immunoglobulin A deficiency. Mol. Immunol. 2016; 71: 1-9. doi: 10.1016/j.molimm.2015.12.016.
  • Español T., Catala M., Hernandes M. et al. Development of a common variable immunodeficiency in IgA-deficient patients. Clin. Immunol. Immunopathol. 1996; 80 (3, Pt. 1): 333-335. doi: 10.1006/clin.1996.0132.
  • Aghamohammadi A., Mohammadi J., Parvaneh N. et al. Progression of selective IgA deficiency to common variable immunodeficiency. Int. Arch. Allergy Imminol. 2008; 147 (2): 87-92. doi: 10.1159/000135694.
  • Dominíngues O., Giner M.T., Alsina L. et al. Clinical phenotypes associated with selective IgA deficiency: a review of 330 cases and a proposed follow-up protocol. An. Pediat (Barc.). 2012; 76 (5): 261-267. doi: 10.1016/j.anpedi.2011.11.006.
  • Mohammadinejad P., Pourhamdi S., Abolhassani H. et al. Primary antibody deficiency in a tertiary referral hospital: a 30-year experiment. J. Investig. Allergol. Immunol. 2015; 25 (6): 416-425. PMID: 26817138.
  • Сhee L., Graham S.M., Carothers D.G., Ballas Z.K. Immune disfunction in refractory sinusitis in a tertiary care setting. Laryngoscope. 2001; 111 (2): 233-235. doi: 10.1097/00005537-200102000-00008.
  • Москалец О.В., Яздовский В.В., Никитина Н.В. Случай селективного дефицита иммуноглобулина А, ассоциированного с аутоиммунным гастритом. Альманах клин. мед. 2016; 44 (6): 790-795. . doi: 10.18786/2072-0505-2016-44-6-790-795.
  • Abolhassani H., Gharib B., Shahinpour S. et al. Autoimmunity in patients with selective IgA deficiency. J. Investig. Allergol. Clin. Immunol. 2015; 25 (2): 112-119. PMID: 25997304.
  • Wang N., Shen N., Vyse T.J. et al. Selective IgA deficiency in autoimmune disease. Mol. Med. 2011; 17 (11-12): 1383-1396. doi: 10.2119/molmed.2011.00195.
  • Захарова И.Н., Боровик Т.Э., Рославцева Е.А. и др. Целиакия: клинические особенности. Consil. Med. Педиатрия (Прил.). 2014; 3: 62-67.
  • Singh K., Chang C., Gershwin M.E. IgA deficiency and autoimmunity. Autoimmun. Rev. 2014; 13 (2): 163-177. doi: 10.1016/j.autrev.2013.10.005.
  • Knight A.K., Bingemann T., Cole L., Cunningham-Rundles C. Friquent false-positive beta human chorionic gonadotropin tests in Immunoglobulin A deficiency. Clin. Exp. Immunol. 2005; 141 (2): 333-337. doi: 10.1111/j.1365-2249.2005.02837.x.

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