Levels of antithrombin III and D-dimers as predictors of pulmonary artery thromboembolism in patients with deep vein thrombosis

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Abstract


Aim. Search for predictors of pulmonary artery thromboembolism in patients with deep vein thrombosis among the indicators of hemostasis system. Methods. Retrospective analysis of indicators of hemostasis system was performed in 23 patients with defined pulmonary artery thromboembolism, 30 patients with deep vein thrombosis and 20 healthy volunteers. Values of platelet aggregation by Born method, concentration of circulating thrombocytic aggregates by Kohanna method, values of thromboelastometry, as well as blood levels of D-dimers and antitrombin III in arterial and venous blood were measured. Results. It was established that in patients from both thrombosis groups, haemostasis system changes are similar in nature: (1) a high value of Wu-Hoak is registered - more than 15 times higher in both arterial and venous blood compared to the control group; (2) platelet aggregation rates demonstrate hyperaggregation with all inductors, both in arterial and venous blood; (3) thromboelastography results are characterized by increased activity of thrombocytic hemostasis, prolonged clotting time, heightened clot strength compared to control in both arterial and venous blood flow. However, the difference was revealed between groups with and without pulmonary thromboembolism in venous blood levels of D-dimers and activity of antithrombin III. A function to predict pulmonary thromboembolism was constructed depending on the level of D-dimers and activity of antithrombin III in patients with deep vein thrombosis. Conclusion. The developed function for prediction of pulmonary artery thromboembolism can objectively assess the likelihood of pulmonary thromboembolism, which in turn allows minimizing risk and timely assessing the effectiveness of taken preventive measures.

A L Urakov

Author for correspondence.
AVSamorodov@gmail.com
Izhevsk State Medical Academy Izhevsk, Russia

K G Gurevich

AVSamorodov@gmail.com
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov Moscow, Russia

F Kh Kamilov

AVSamorodov@gmail.com
Bashkir State Medical University Ufa, Russia

K N Zolotukhin

AVSamorodov@gmail.com
Republican Clinical Hospital named after G.G. Kuvatov Ufa, Russia

A V Samorodov

AVSamorodov@gmail.com
Bashkir State Medical University; Republican Clinical Hospital named after G.G. Kuvatov Ufa, Russia; Ufa, Russia

F A Khaliullin

AVSamorodov@gmail.com
Bashkir State Medical University Ufa, Russia

  • European Society of Cardiology. Guidelines on the diagnosis and management of acute pulmonary embolism. Eur. Heart J. 2014; 35: 3033-3080. doi: 10.1093/eurheartj/ehu283.
  • Рамазанова А.Х., Мустафин И.Г., Одинцова А.Х. и др. Воспалительные заболевания кишечника и тромбоэмболические осложнения: новая проблема. Практич. мед. 2015; 4 (2): 90-92.
  • Urakov A., Urakova N. Rheology and physical-chemical characteristics of the solutions of the medicines. J. Phys. Conference Series. 2015; 602: 012043. doi: 10.1088/1742-6596/602/1/012043.
  • Леонтьев С.А., Леонтьева Н.В., Дмитриева Я. и др. Ранние осложнения и отсроченные результаты повторных операций на аортальном клапане. Опыт центра сердца университета Лейпцига (Германия). Креативная хирургия и онкология. 2017; 7 (3): 4-12. doi: 10.24060/2076-3093-2017-7-3-4-12.
  • Urakov A.L. The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties. Epitőanyag - J. Silicate Based and Composite Materials. 2015; 67 (1): 2-6. doi: 10.14382/epitoanyag-jsbcm.2015.1.
  • Амзаев С.А., Сергеев А.С., Сухов В.К. и др. Возможности интервенционной коррекции критического аортального стеноза: современное состояние проблемы и перспективы. Креативн. хир. и онкол. 2017; 7 (1): 4-10. doi: 10.24060/2076-3093-2017-7-1-4-10.
  • Шапошников С.А., Синьков С.В., Заболотских И.Б. Периоперационная тромбопрофилактика у пациентов с нарушениями системы гемостаза. Креативн. хир. и онкол. 2012; (2): 81-86. doi: 10.24060/2076-3093-2012-0-2-81-86.
  • Kohanna F.H., Smith M.H., Salzman E.W. Do patients with thromboembolic disease have circulating platelet aggregates? Blood. 1984; 64 (1): 205-209. PMID: 6733272.
  • Caprini J.A., Glase S.J., Anderson C.B. et al. Laboratory markers in the diagnosis of venous thromboembolism. Circulation. 2004; 109: I-4-I-8. doi: 10.1161/01.CIR.0000122869.59485.36.
  • Kodiatte T.A., Manikyam U.K., Rao S.B. et al. Mean platelet volume in type 2 diabetes mellitus. J. Lab. Physicians. 2012; 4 (1): 5-9. doi: 10.4103/0974-2727.98662.
  • Kuderer N.M., Poniewierski M.S., Culakova E. et al. Predictors of venous thromboembolism and early mortality in lung cancer: Results from a Global Prospective Study (CANTARISK). Oncologist. 2017; theoncologist.2017-0205. doi: 10.1634/theoncologist.2017-0205.

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© 2017 Urakov A.L., Gurevich K.G., Kamilov F.K., Zolotukhin K.N., Samorodov A.V., Khaliullin F.A.

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