Pseudoexfoliation syndrome and ocular adnexa

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Abstract

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease of the connective tissue. Therefore, it is reasonable to evaluate the condition of ocular adnexa in patients with PEX. The purpose of the study. To evaluate the state of ocular adnexal tissue in PEX. Methods. Both eyes of 66 patients with PEX and of 64 control individuals were examined in this prospective study. We evaluated the function of the upper eyelid levator muscles and the lower eyelid retractors, horizontal lid laxity (HLL), canthal integrity, degree of retractor disinsertion, and orbicularis muscle tone. Results. The HLL, degree of retractor disinsertion, and the laxity of the medial canthal tendon were statistically expressed in patients with PEX (p < 0.05). However, the orbicularis muscle tone and the function of the lower eyelid retractors were statistically lower in these patients (p < 0.05). The function of the upper eyelid levator muscles, tone of the lateral canthal tendon and degree of ptosis was found to be similar in both groups. Conclusion. Signs of atonic changes in ocular adnexa are relatively more common in patients with PEX (p < 0.05).

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About the authors

Vitaly V. Potemkin

First Pavlov State Medical University of St Petersburg

Author for correspondence.
Email: potem@inbox.ru

MD, PhD, assistant professor

Russian Federation

Vyacheslav V. Rakhmanov

First Pavlov State Medical University of St Petersburg

Email: rakhmanoveyes@yandex.ru

MD, PhD

Russian Federation

Elena V. Ageeva

First Pavlov State Medical University of St Petersburg

Email: ageeva_elena@inbox.ru

resident

Russian Federation

Aisa S. Alchinova

First Pavlov State Medical University of St Petersburg

Email: aalchinova@mail.ru

resident

Russian Federation

Elena V. Meshveliani

First Pavlov State Medical University of St Petersburg

Email: lena_vm@inbox.ru

resident

Russian Federation

References

  1. Астахов Ю.С., Николаенко В.П. Офтальмология. Фармакотерапия без ошибок. — М., 2016. — С. 307–338. [Astahov JS, Nikolaenko VP. Oftal’mologija. Farmakoterapija bez oshibok. Moscow; 2016. P. 307-338. (In Russ.)]
  2. Бровкина А.Ф., Астахов Ю.С. Руководство по клинической офтальмологии. — М., 2014. — С. 78–118. [Brovkina AF, Astahov JS. Rukovodstvo po klinicheskoj oftal’mologii. Moscow; 2014. P. 78-118. (In Russ.)]
  3. Николаенко В.П., Астахов Ю.С. Орбитальные переломы. — СПб., 2012. — С. 12–79. [Nikolaenko VP, Astahov JS. Orbital’nye perelomy. Saint Petersburg; 2012. P. 12-79.
  4. (In Russ.)]
  5. Потёмкин В.В., Рахманов В.В., Агеева Е.В., и др. Дисфункция мейбомиевых желёз у пациентов с инволюционными нарушениями положения век // Офтальмологические ведомости. — 2016. — Том 9. — № 1. — С. 2–5. [Potemkin VV, Rahmanov VV, Ageeva EV, et al. Disfunkcija mejbomievyh zheljoz u pacientov s involjucionnymi narushenijami polozhenija vek. Oftal’mologicheskie vedomosti. 2016;9(1):2-5 (In Russ.)]
  6. Потёмкин В.В., Агеева Е.В. Состояние глазной поверхности при псевдоэксфолиативном синдроме. Ученые записки СПбГМУ им. акад. И. П. Павлова. — 2016. — Том XXIII. — № 1. — С. 47–50. [Potemkin VV, Ageeva EV. Sostojanie glaznoj poverhnosti pri psevdojeksfoliativnom sindrome. Uchenye zapiski SPbGMU im. akad. I.P. Pavlova. 2016;23(1):47-50. (In Russ.)]
  7. Anderson RL, Gordy DD. The tarsal strip procedure. Arch Ophthalmol. 1979;97:192-195. doi: 10.1001/archopht.
  8. 01020020510021.
  9. Boldt J, Höh H. Lid-parallel conjunctival folds (LIPCOFs) are also a reliable indication of the dry eye condition in patients with diabetes, regardless of the regulation of the diabetes. Contactologia. 2000;22:68-73.
  10. Bojic L, Ermacora R, Polic S, et al. Pseudoexfoliation syndrome and asymptomatic myocardial dysfunction. Graefes Arch Clin Exp Ophthalmol. 2005;243:446-449. doi: 10.1007/s00417-004-1074-9.
  11. Bron AJ, Benjamin L, Snibson GR. Meibomian gland disease: classification and grading of lid changes. Eye. 1991;5:395-41. doi: 10.1038/eye.1991.65.
  12. Bialasiewicz AA, Wali U, Shenoy R, Al-Saeidi R. Patients with secondary open-angle glaucoma in pseudoexfoliation (PEX) syndrome among a population with high prevalence of PEX. Clinical findings and morphological and surgical characteristics. Ophthalmologe. 2006;102:1064-1068. doi: 10.1007/s00347-005-1226-2.
  13. Cahill M, Early A, Stack S, et al. Pseudoexfoliation and sensorineural hearing loss. Eye. 2002;16:261-266. doi: 10.1038/sj.eye.6700011.
  14. Callahan A. Reconstructive Surgery of the Eyelids and Ocular Adnexa. Birmingham: Aesculapius; 1966. P. 140-157.
  15. Challa P. Genetics of pseudoexfoliation syndrome. Curr Opin Ophthalmol. 2009;20:88-91. doi: 10.1097/ICU.0b013e328320d86a.
  16. Collin JRO. A Manual of Systematic Eyelid Surgery, 3th edition. 2006. P. 57-85.
  17. Chew CKS, Hykin PG, Jansweijer C, et al. The casual level of meibomian lipids in humans. Curr Eye Res. 1993;12:255-259. doi: 10.3109/02713689308999471.
  18. Collin JRO, Rathbun JE. Involutional entropion — a review with evaluation of a procedure. Arch Ophthalmol. 96:1058-1064, 1978. doi: 10.1001/archopht.1978.03910050578018.
  19. Damasceno RW, Osaki MH, Dantas PE, Belfort RJr. Involutional ectropion and entropion: clinicopathologic correlation between horizontal eyelid laxity and eyelid extracellular matrix. Ophthal Plast Reconstr Surg. 2011 Sep-Oct; 27(5):321-326. doi: 10.1097/IOP.0b013e31821637e4.
  20. Dalgleish R, Smith JL. Mechanics and histology of senile entropion. Br J Ophthalmol. 50(2):79-91. doi: 10.1136/bjo.50.2.79.
  21. Damasceno RW, Osaki MH, Dantas PE, Belfort RJr. Involutional entropion and ectropion of the lower eyelid: prevalence and associated risk factors in the elderly population. Ophthal Plast Reconstr Surg. 2011 Sep-Oct;27(5):317-320. doi: 10.1097/IOP.0b013e3182115229.
  22. Erdogan H, Arici DS, Toker MI. Conjunctival impression cytology in pseudoexfoliative glaucoma and pseudoexfoliation syndrome. Clin Experim Ophthalmol. 2006;34:108-113. doi: 10.1111/j.1442-9071.2006.01168.x.
  23. Hawes MJ, Dortzbach RK. The microscopic anatomy of the lower lid retractors. Arch Ophthalmol. 1982;100:1313-1318. doi: 10.1001/archopht.1982.01030040291018.
  24. Hargiss JL. Inferior aponeurosis revisited. Ophthalmology. 1980;87:1001-1004. doi: 10.1016/S0161-6420(80)35133-6.
  25. Hill JC. Analysis of senile changes in the palpebral fissure. Trans Ophthalmol Soc UK. 1975;95(pt 1):49.
  26. Iyengar SS, Dresner SC. Entropion. Smith and Nesi᾿s Ophthalmic Plastic and Reconstructive Surgery. 3rd ed. New York (NY): Springer; 2012. P. 311-315. doi: 10.1007/978-1-4614-0971-7_17.
  27. Kaštelan S, Tomić M, Kordić R, et al. Cataract Surgery in Eyes with Pseudoexfoliation (PEX) Syndrome. J Clinic Experiment Ophthalmol. 2013; S1:009
  28. Kocabeyoğlu S, İrkec M, Orhan M, Mocan M. Evaluation of the Ocular Surface Parameters in Pseudoexfoliation Syndrome and Conjunctivochalasis, Hacettepe University School of Medicine, Department of Ophthalmology, 2012.
  29. Kevin SM, Craig NC, Kenneth VC, et al. Age-Matched, Case-Controlled Comparison of Clinical Indicators for Development of Entropion and Ectropion. J of Ophthalmology. 2014:7.
  30. Kozart DM, Yanoff M. Intraocular pressure status in 100 consecutive patients with exfoliation syndrome. Ophthalmology. 1982;89:214-218. doi: 10.1016/S0161-6420(82)
  31. -6.
  32. Koliakos GG, Konstas AG, Schlötzer-Schrehardt U, et al. 8-Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol. 2003;87:353-356. doi: 10.1136/bjo.87.3.353.
  33. Koliakos GG, Befani CD, Mikropoulos D, et al. Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. Graefes Arch Clin Exp Ophthalmol. 2008;246:1477-1483. doi: 10.1007/s00417-008-0871-y.
  34. Linner E, Popovic V, Gottfries CG, et al. The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer’s type. Acta Ophthalmol Scand. 2001;79:283-285. doi: 10.1034/j.1600-0420.2001.790314.x.
  35. Meller D, Tseng SCG. Conjunctivochalasis: Literature review and possible pathophysiology. Surv Ophthalmol. 1998;43:225-232. doi: 10.1016/S0039-6257(98)00037-X.
  36. Micheal S, Khan MI, Akhtar F. Role of Lysyl oxidase-like 1 gene polymorphisms in Pakistani patients with pseudoexfoliative glaucoma. Mol Vis. 2012;18:1040-1044.
  37. Mitchell P, Wang JJ, Smith W. Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol. 1997;124:685-687. doi: 10.1016/S0002-9394(14)70908-0.
  38. Naumann GO, Schlötzer-Schrehardt U, Küchle M. Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology. 1998:951-968. doi: 10.1016/S0161-6420(98)96020-1.
  39. Nowinski TS. Entropion. Color Atlas of Oculoplastic Surgery. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2011. P. 44-53.
  40. Pflugfelder SC, Tseng SG, Sanabria O, et al Evaluation of subjective assessments and objective diagnostic tests for diagnosing tear-film disorders known to cause ocular irritation. Cornea.1998;17:38-56. doi: 10.1097/00003226-199801000-00007.
  41. Repo LP, Teräsvirta ME, Koivisto KJ. Generalized transluminance of the iris and the frequency of the pseudoexfoliation syndrome in the eyes of transient ischemic attack patients. Ophthalmology. 1993;100:352-355. doi: 10.1016/S0161-6420(93)31642-8.
  42. Ritch R. Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. J Glaucoma. 1994;3:176-177. doi: 10.1097/00061198-199400320-00018.
  43. Ritch R, Schlotzer-Schrehardt U. Exfoliation syndrome. Survey of Ophthalmology. 2001;45:265-313.
  44. Schlötzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalm. 2006:921-937.
  45. Summanen P, Tönjum AM. Exfoliation syndrome. Act Ophthalmol. Suppl. 1998;184: 107-111.
  46. Schlötzer-Schrehardt U, Koca M, Naumann GO, Volkholz H. Pseudoexfoliation syndrome: ocular manifestation of a systemic disorder. Arch Ophthalmol. 1992;110:1752-1756. doi: 10.1001/archopht.1992.01080240092038.
  47. Streeten BW, Li Z-Y, Wallace RN, et al. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol. 1992;110:1757-1762. doi: 10.1001/archopht.1992.01080240097039.
  48. Schumacher S, Schlötzer-Schrehardt U, Martus P, et al. Pseudoexfoliation syndrome and aneurysms of the abdominal aorta. Lancet. 2001;357:359-360. doi: 10.1016/S0140-6736(00)03645-X.
  49. Streeten BW, Gibson SA, Dark AJ. Pseudoexfoliative material contains an elastic microfibrillar-associated glycoprotein. Trans Am Ophthalmol Soc. 1986;84:304-320.
  50. Takai Y, Tanito M, Ohira A. Multiplex cytokine analysis of aqueous humor in eyes with primary open-angle glaucoma, exfoliation glaucoma, and cataract. Invest Ophthalmol Vis Sci.2012;53:241-247. doi: 10.1167/iovs.11-8434.
  51. Zenkel M, Pöschl E, von der Mark K, et al. Differential gene expression in pseudoexfoliation syndrome. Invest Ophthalmol. 2005;46:3742-3752. doi: 10.1167/iovs.05-0249.

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Copyright (c) 2016 Potemkin V.V., Rakhmanov V.V., Ageeva E.V., Alchinova A.S., Meshveliani E.V.

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