Pseudoexfoliation syndrome and meibomian gland dysfunction

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Abstract

Pseudoexfoliation syndrome (PEX) is a relatively widespread generalized age-related disease of connective tissue. The condition of meibomian glands in patients with PEX was not evaluated yet. Aim. To evaluate the condition of meibomian glands in PEX. Methods. Overall, 132 eyes of 66 patients with PEX syndrome and 128 eyes of 64 patients without it were enrolled in this prospective study. Results. The signs of atonic changes in meibomian glands were similar in both groups. Meibomian glands dysfunction was significantly more expressed in patients with PEX (p < 0,05).

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About the authors

Vitaly V Potemkin

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Author for correspondence.
Email: potem@inbox.ru

PhD, assistant professor. Department of Ophthalmology

Russian Federation

Elena V Ageeva

FSBEI HE I.P. Pavlov SPbSMU MOH Russia

Email: ageeva_elena@inbox.ru

resident. Department of Ophthalmology

Russian Federation

References

  1. Бровкина А.Ф., Астахов Ю.С. Руководство по клинической офтальмологии. – М., 2014. – С. 78–118. [Brovkina AF, Astahov JS. Rukovodstvo po klinicheskoj oftal’mologii. Moscow; 2014. P. 78-118. (In Russ.)]
  2. Бржеский В.В., Астахов Ю.С., Кузнецова Н.Ю. Заболевания слёзного аппарата. – М., 2009. [Brzheskiy VV, Astakhov YS, Kuznetsova NYu. Zabolevaniya sleznogo apparata. Moscow; 2009. (In Russ.)]
  3. Брежнев А.Ю., Баранов В.И., Петров С.Ю. Псевдоэксфолиативный синдром как фактор риска развития синдрома «сухого глаза» // Клиническая офтальмология. – 2016. – Т. 16. – № 1. – С. 30–34. [Brezhnev AYu, Baranov VI, Petrov SYu. Psevdoeksfoliativnyy sindrom kak faktor riska razvitiya sindroma “sukhogo glaza”. Klinicheskaya oftal’mologiya. 2016;16(1)30-34. (In Russ.)]
  4. Николаенко В.П., Астахов Ю.С. Орбитальные переломы. – СПб., 2012. – С. 12–79. [Nikolaenko VP, Astakhov YuS. Orbital’nye perelomy. Saint Petersburg; 2012. P. 12-79. (In Russ.)]
  5. Потёмкин В.В., Агеева Е.В. Состояние глазной поверхности при псевдоэксфолиативном синдроме // Учёные записки СПбГМУ им. акад. И.П. Павлова. – 2016. – Т. 23. – № 1. – С. 47–50. [Potemkin VV, Ageeva EV. Sostoyanie glaznoy poverkhnosti pri psevdoeksfoliativnom syndrome. Uchenye zapiski SPbGMU im. akad. I.P. Pavlova. 2016;23(1):47-50. (In Russ.)]
  6. Astrom S, Linden C. Incidence and prevalence of pseudoexfoliation and open-angle glaucoma in northern Sweden: I. Baseline report. Act Ophthalmol Scand. 2007;85(8):828-831. doi: 10.1111/j.1600-0420.2007.00992.x.
  7. Bojic L, Ermacora R, Polic S, et al. Pseudoexfoliation syndrome and asymptomatic myocardial dysfunction. Graefes Arch. Clin Exp Ophthalmol. 2005;243:446-449. doi: 10.1007/s00417-004-1074-9.
  8. Bron AJ, Benjamin L, Snibson GR. Meibomian gland disease: classification and grading of lid changes. Eye. 1991;5:395-41. doi: 10.1038/eye.1991.65.
  9. Bialasiewicz AA, Wali U, Shenoy R, Al-Saeidi R. Patients with secondary open-angle glaucoma in pseudoexfoliation (PEX) syndrome among a population with high prevalence of PEX. Clinical findings and morphological and surgical characteristics. Ophthalmologe. 2005;102(11):1064-1068. doi: 10.1007/s00347-005-1226-2.
  10. DEWS. Methodologies to diagnose and monitor dry eye disease. Report of the Diagnostic Methodology Subcomittee of the International Dry Eye Workshop. Ocul Surf. 2007;5(2):108-152. doi: 10.1016/S1542-0124(12)70083-6.
  11. Detorakis ET, Koukoula S, Chrisohoou F, et al. Central corneal mechanical sensitivity in pseudoexfoliation syndrome. Cornea. 2005;24:688-691. doi: 10.1097/01.ico.0000154232.18618.e0.
  12. Erdogan H, Arici DS, Toker MI. Conjunctival impression cytology in pseudoexfoliative glaucoma and pseudoexfoliation syndrome. Clin Experim Ophthalmol. 2006;34(2):108-113. doi: 10.1111/j.1442-9071.2006.01168.x.
  13. Foster PJ, Seah SK. The prevalence of pseudoexfoliation syndrome in Chinese people: The Tanjong Pagar Survey. Br J Ophthalmol. 2005;89:239-240. doi: 10.1136/bjo.2004.047605.
  14. Hykin PG, Bron AJ. Age-related morphological changes in lid margin and meibomian gland anatomy. Cornea. 1992;11:334-342. doi: 10.1097/00003226-199207000-00012.
  15. Hirvela H, Luukinen H, Laatikainen L. Prevalence and risk factors of lens opacities in the elderly in Finland. A population-based study. Ophthalmology. 1995;102(1):108-117. doi: 10.1016/S0161-6420(95)31072-X.
  16. Jonas JB, Nangia V, Matin A, et al. Pseudoexfoliation: normative data and associations. The central India eye and medical study. PLoS One. 2013;8: e76770.
  17. Koliakos GG, Befani CD, Mikropoulos D, et al. Prooxidant-antioxidant balance, peroxide and catalase activity in the aqueous humour and serum of patients with exfoliation syndrome or exfoliative glaucoma. Graefes Arch. Clin Exp Ophthalmol. 2008;246(10):1477-1483. doi: 10.1007/s00417-008-0871-y.
  18. Kaštelan S, Tomić M, Kordić R, et al. Cataract Surgery in Eyes with Pseudoexfoliation (PEX) Syndrome. J Clinic Exp Ophthalmol. 2013;S1:009.
  19. Kocabeyoğlu S, İrkec M, Orhan M, Mocan M. Evaluation of the Ocular Surface Parameters in Pseudoexfoliation Syndrome and Conjunctivochalasis, Hacettepe University School of Medicine, Department of Ophthalmology, 2012.
  20. Linner E, Popovic V, Gottfries C-G, et al. The exfoliation syndrome in cognitive impairment of cerebrovascular or Alzheimer’s type. Acta Ophthalmol Scand. 2001;79(3):283-285. doi: 10.1034/j.1600-0420.2001.790314.x.
  21. Mitchell P, Wang J, Hourihan F. The relationship between glaucoma and pseudoexfoliation. The Blue Mountains Eye Study. Arch Ophthalmol. 1999;117(10):1319-1324. doi: 10.1001/archopht.117.10.1319.
  22. Miyazaki M, Kubota T, Kubo M, et al. The prevalence of pseudoexfoliation syndrome in a Japanese population: the Hisayama study. J Glaucoma. 2005;14:482-484. doi: 10.1097/01.ijg.0000185436.15675.b3.
  23. Musch DC, Sugar A, Meyer RF. Demographic and predisposing factors in corneal ulceration. Arch Ophthalmol. 1983;101(10):1545-8. doi: 10.1001/archopht.1983.01040020547007.
  24. Naumann GO, Schlötzer-Schrehardt U, Küchle M. Pseudoexfoliation syndrome for the comprehensive ophthalmologist. Intraocular and systemic manifestations. Ophthalmology. 1998;105(6):951-968. doi: 10.1016/S0161-6420(98)96020-1.
  25. Ritch R, Schlötzer-Schrehardt U. Exfoliation syndrome. Survey of Ophthalmology. 2001;45(4):265-313. doi: 10.1016/S0039-6257(00)00196-X.
  26. Ritch R. Exfoliation syndrome-the most common identifiable cause of open-angle glaucoma. J Glaucoma. 1994;3:176-177. doi: 10.1097/00061198-199400320-00018.
  27. Repo LP, Teräsvirta ME, Koivisto KJ. Generalized transluminance of the iris and the frequency of the pseudoexfoliation syndrome in the eyes of transient ischemic attack patients. Ophthalmology. 1993;100(3):352-355. doi: 10.1016/S0161-6420(93)31642-8.
  28. Schumacher S, Schlötzer-Schrehardt U, Martus P, et al. Pseudoexfoliation syndrome and aneurysms of the abdominal aorta. Lancet. 2001;357(9253):359-360. doi: 10.1016/S0140-6736(00)03645-X.
  29. Schlötzer-Schrehardt U, Naumann GO. Ocular and systemic pseudoexfoliation syndrome. Am J Ophthalm. 2006:921-937.
  30. Summanen P, Tönjum AM. Exfoliation syndrome. Act Ophthalmol. 1998: 184(Suppl.):107-111.
  31. Schlötzer-Schrehardt U, Koca M, Naumann GO, Volkholz H. Pseudoexfoliation syndrome: ocular manifestation of a systemic disorder. Arch Ophthalmol. 1992;110(12):1752-1756. doi: 10.1001/archopht.1992.01080240092038.
  32. Streeten BW, Li Z-Y, Wallace RN, et al. Pseudoexfoliative fibrillopathy in visceral organs of a patient with pseudoexfoliation syndrome. Arch Ophthalmol. 1992;110(12):1757-1762. doi: 10.1001/archopht.1992.01080240097039.

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