The comparative efficacy and tolerability of the latest fluoroquinolones in pediatric ophthalmology

The authors analyze the results of treatment of 45 children with bacterial conjunctivitis (87 eyes). All patients were divided into 3 groups: children of the first group received instillations of 0.3 % ofloxacin (Uniflox, Unimed Pharma), the second — 0.5 % levofloxacin (Oftaquix, Santen or Signizef, Promed Exports), the third — 0.3 % ciprofloxacin (Ciprolet, Dr Reddy`s Laboratories; Cilloxan, Alcon; Cipromed, Promed Exports). The patients received one of the above-mentioned fluoroquinolones 1 drop to each eye 5 times a day during 7 days. All patients were examined: plating of conjunctival cavity content, biomicroscopy of cornea and conjunctiva, staining of cornea and conjunctiva with fluorescein, measurement of tear film stability. All patients filled the questionnaire to estimate the tolerability of drugs. Results: eye drops containing 0.3 % ofloxacin, 0.5 % levofloxacin and 0.3 % ciprofloxacin showed equally high clinical effectiveness. The tolerability of ofloxacin and lexofloxacin drops was higher than ciprofloxacin according to subjective and objective (toxic effect to cornea) criteria.

fluoroquinolones, clinical effectiveness, tolerance, children