Clinical current and structural changes of pulmonary tissue at children with a bronchopulmonary dysplasia in the anamnesis


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Bronchopulmonary dysplasia is currently the most common chronic lung disease in preterm infants. Since the initial description of the disease, more than forty years ago, new treatments and technologies have improved the outcome for preterm infants with very - low and extremely - low - birth - weight. As a result, the survival of extremely premature infants has increased but, despite of the improvement in neonatal care, the incidence of bronchopulmonary dysplasia continues to grow. At the same time the consequences of this disease for life has not yet been determined. The aim of the study to determine the clinical course, structural and functional changes in the lungs. In this study we surveyed 44 primary school children and adolescents who have had bronchopulmonary dysplasia in infancy. The children was carried out computed tomography of the lungs, research of function of external breath by methods of impulse oscillometry, spirometry, a body plethysmography, and also research of diffusion lung capacity. The features of the clinical course at different ages, the functional state of the respiratory system, as well as structural changes in the lung tissue. In school children and adolescents with a history of bronchopulmonary dysplasia found long - term structural changes in the lungs as inhomogeneity of ventilation and fibrotic changes on computed tomography of the thorax and also had evidence of airflow obstruction in the result of pulmonary function tests, in the absence of significant clinical signs of respiratory disease.

Full Text

Restricted Access

About the authors

Elena Yu Zapevalova

Scientific Research Institute Pulmonologists of the Scientific and Clinical Research Center State Budget Educational Institution "The First St. Petersburg State Medical University"

Email: elena.zapevalova-13@yandex.ru
Junior researcher, Laboratory of Children's Pulmonology of Scientific Research Institute Pulmonologists of the Scientific and Clinical Research Center. State Budget Educational Institution “The First St.Petersburg State Medical University”

Julia B Klyukhina

Saint Petersburg State Pediatric Medical University of Health Ministry of Russia

Email: julich74@mail.ru
MD, PhD, Assistant Professor, Department of Pediatrics, Endocrinology and Abilitologу AF and DPO. St. Petersburg State Pediatric Medical University.

Evgeniya V Boitsova

Scientific Research Institute Pulmonologists of the Scientific and Clinical Research Center State Budget Educational Institution "The First St. Petersburg State Medical University"

Email: evboitsova@mail.ru
MD, PhD, Dr Med Sci, Professor, Head, Laboratory of Children's Pulmonology of Scientific Research Institute Pulmonologists of the Scientific and Clinical Research Center. State Budget Educational Institution “The First St. Petersburg State Medical University”.

Marina A Kirbyatieva

Leningrad Regional Children Clinical Hospita

Email: julich74@mail.ru
Associate Professor, Head, Department of Radiologydyagnostic. Leningrad Regional Children Clinical Hospital.

References

  1. Баранов А.А., Баранова-Намазова Л.С., Давыдова И.С. Современные подходы к профилактике, диагностике и лечению бронхолегочной дисплазии: руководство для практических врачей. - М.: Педиатръ, 2013. [Baranov AA, Baranova-Namazova LS, Davydova IS. Modern approaches to prevention, diagnosis and treatment of bronchopulmonary dysplasia: rukovodstvo dlya prakticheskikh vrachey. Moscow: Pediatr; 2013. (In Russ).]
  2. Бойцова Е.В., Запевалова Е.Ю., Овсянников Д.Ю. Бронхолегочная дисплазия: клинико-функцио¬нальные последствия у детей, подростков и молодых взрослых // Земский врач. - 2013. - № 4. - C. 9-12. [Boytsova EV, Zapevalova EY, Ovsyannikov DY. Bronchopulmonary dysplasia: clinical and functional consequences in children, adolescents and young adults. Zemskiy vrach. 2013;(4):9-12 (In Russ).]
  3. Давыдова И.В. Формирование, течение и исходы бронхолегочной дисплазии у детей: Автореф. дис. … д-ра мед. наук. - М., 2010. [Davydova IV. The development, course and outcomes of bronchopulmonary dysplasia in children [dissertation]. Moscow; 2010 (In Russ).]
  4. Классификация клинических форм бронхолегочных заболеваний у детей. - М.: Российское респираторное общество, 2009. [The classification of clinical forms of bronchopulmonary diseases in children. Moscow: Rossiyskoe respiratornoe obshchestvo; 2009 (In Russ).]
  5. Овсянников Д.Ю. Система оказания медицинской помощи детям, страдающим бронхолегочной дисплазией: руководство для практикующих врачей. - М.: МДВ, 2010. [Ovsyannikov DY. The health care system suffering from bronchopulmonary dysplasia: rukovodstvo dlya praktikuyushchikh vrachey. Moscow: MDV; 2010 (In Russ).]
  6. Овсянников Д.Ю. Бронхолегочная дисплазия у детей первых трех лет жизни: Автореф. дис. … д-ра мед.наук. - М., 2010. [Ovsyannikov DY. Bronchopulmonary dysplasia in children of the first three years of life [dissertation]. Mocow; 2010 (In Russ).]
  7. Deakins KM. Bronchopulmonary dysplasia. Respiratory care. 2009;54(9):1252-62.
  8. Doyle LW, Faber B, Callanan C, et al. Bronchopulmonary Dysplasia in Very Low Weight Subjects and Lung Function in Late Adolescence. Pediatrics. 2006;118 (1):108-14. doi: 10.1542/peds.2005-2522.
  9. Eber E, Zach MS. Long term sequelae of bronchopulmonary dysplasia (chronic lung disease of infancy). Thorax. 2001;56:317-23.
  10. Fawke J, Lum S, Kirkby J, et al. Lung function and respiratory symptoms at 11 years in children born extremely preterm. Am J Respir Crit Care Med. 2010; 182(2):237-45. doi: 10.1164/rccm.200912-1806oc.
  11. Global Initiative for Asthma - www.ginasthma.org (2014).
  12. Grenough A, Kotecha S, Vrijlandt E. Bronchopul-monary dysplasia: current models and concepts. Eur Respir Mon.2006;37:217-33. doi: 10.1183/1025448x.00037014.
  13. Hilgendorff A, O´Reilly MA. Bronchopulmonary dysplasia early changes leading to long-term consequences. Frontiers in Medicine. 2015;2:1-10. doi: 10.3389/fmed.2015.00002.
  14. Howling SJ, Northway W H, et al. Pulmonary sequelae of bronchopulmonary dysplasia survivors: High-resolution CT findings. AJR. 2000;174(5):1323-26. doi: 10.2214/ajr.174.5.1741323.
  15. Jobe AN. The New Bronchopulmonary dysplasia. Curr Opin Pediatr. 2011;23(2):167-72.
  16. Koumbourlis AC, Motoyama EK, Mutich RL, et al. Longitudinal follow-up of lung function from childhood to adolescence in prematurely born patients with neonatal chronic lung disease. Pediatr Pulmonol. 1996;21(1):28-34.doi: 10.1002/(sici)1099-0496(199601)21:1<28::aid-ppul5>3.0.co;2-m.
  17. Landry JS, Chan T, Lands L, Menzies D. Long-term impact of bronchopulmonary dysplasia on pulmonary function.Can Respir J. 2011;18(5):265-70. doi: 10.1155/2011/547948. doi: 10.1136/adc.74.3.188.
  18. McLeod A, Ross P, Mitchell S. Respiratory health in a total very low birthweight. Arch Dis Child. 1996;74(3):188-94. doi: 10.1136/adc.74.3.188.
  19. Northway WH, Moss RB, Carlisle KB, et al. Late pulmonary sequelae of bronchopulmonary dysplasia. N Engl J Med. 1990;323(26):1793-99. doi: 10.1056/nejm199012273232603.
  20. Northway WH, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyaline membrane disease. N Engl J Med. 1967;276(7): 357-68. doi: 10.1056/nejm196702162760701.
  21. Oppenheim C, Mamou-Mani T, Sayeghi N, et al. Bronchopulmonary dysplasia: value of CT in identifying pulmonary sequelae. AJR. 1994;163(1): 169-72. doi: 10.2214/ajr.163.1.8010206.
  22. Pelkonen AS, Hakulinen AL, Turpeinen M. Bronchial lability and responsiveness in schoolchildren born very preterm. Am J Respir Crit Care Med. 1997;156(4):1178-84. doi: 10.1164/ajrccm.156.4.9610028.
  23. Vrijlandt EJLE, Gerritsen J, Boezen HM, et al. Lung function and exercise capacity in young adults born prematurely. Am J Respir Crit Care Med. 2006;173(8):890-6. doi: 10.1164/rccm.200507-1140oc.
  24. Wong PM, Lees AN, Louw J, et al. Emphysema in young adult survivors of moderate-to-severe bronchopulmonary dysplasia. Eur Respire J. 2008;32(2):321-8. doi: 10.1183/09031936.00127107.
  25. Zysman-Colman Z, Tremblay GM, Bandeali S, Landry JS. Bronchopulmonary dysplasia - trends over three decades. Pediatr Child Health. 2013;18(2):86-90.
  26. Клюхина Ю.Б., Желенина Л.А., Иванов Д.О. Пульмонологический катамнез детей, находившихся на искусственной вентиляции легких в периоде новорожденности // Педиатр. - 2014. - № 3. - C. 16-21. [Kljuhina JB, Zhelenina LA, Ivanov DO. Pulmonary catamnesis in children on artifical lung ventilation in the neonatal period. Pediatr. 2014;(3):16-21. (In Russ).]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Zapevalova E.Y., Klyukhina J.B., Boitsova E.V., Kirbyatieva M.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 69634 от 15.03.2021 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies