History of the study of hemorrhagic disease of newborns

Cover Page

Abstract


The article describes the main historical periods of the study of hemorrhagic disease of newborns. Clinical observations, describing bleeding of newborns, which occurs without visible damage, known since the seventeenth century and are found in the works of Francois Mauriceau and Georg Wolfgang Wedel. The role of the liver injury in the development of bleeding of infants noticed English physicians John Huxham (1672-1768) and John Cheyne (1777-1836). In 1871 Ludwig Grandidier conducted differential diagnosis between umbilical bleeding of neonates and the hemophilia clinic. Later I.P. Pavlov showed, that the clotting time of dog’s blood significantly prolongs when you turn off the liver from the blood circulation. In that way, partly began to understand the etiology of hemorrhagic syndrome, but the pathogenesis of this suffering, in diseases of the liver remained unknown. Charles Wendell Townsend in 1894, describing 50 cases of coagulopathy of newborns, at the first time paid attention to the connection between breastfeeding and development of bleeding and offered to call this nosological form as "hemorrhagic disease of newborns". In the late 20s of the last century Henrik Dam have identified the unknown substances from green lucerne leaves and described them as the fat-soluble vitamin K (coagulation). In 1943 H. Dam and E. Doisy received the Nobel prize for the discovery and establishment of the chemical structure of vitamin K. In 1943, a group of Soviet biochemists have synthesized a water-soluble analogue of vitamin K (K3, vicasolum), quickly introduced into clinical practice and showed their high efficiency in patients with hypovitaminosis K. In 1945 Yu.F. Dombrovskaya suggested that haemorrhagic disease of newborns caused by deficit of vitamin K. Further researching of the development of haemorrhagic disease of newborns is associated with the study of the biochemistry of the pathogenesis of the disease, identify its various forms and development of treatment techniques and prevention, depending on the identified features.


Dmitry O. Ivanov

Author for correspondence.
doivanov@yandex.ru
St Petersburg State Pediatric Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation, Saint Petersburg

MD, PhD, Dr Med Sci, Professor, Rector

  • Sutor AH, von Kries R, Cornelissen EA, et al. Vitamin K deficiency bleeding (VKDB) in infancy. ISTH pediatric/perinatal subcommittee. International society on thrombosis and haemostasis. Thromb Haemost. 1999;81:456-61.
  • Woods CW, Woods AG, Cederholm CK. Vitamin K deficiency bleeding: a case study. Adv Neonatal Care. 2013;13(6):402-407. doi: 10.1097/ANC.0000000000000026.
  • Seguna R, Maw KZ, Lyall HD, Bowles KM. “Haemorrhagic disease of the newborn” 89 years later than expected: vitamin K deficiency bleeding. Lancet. 2014;384(9942):556. doi: 10.1016/S0140-6736(14)60999-5.
  • Шабалов Н.П. Неонатология. Учебное пособие для студентов: в 2 т. – 7-е изд., испр. и доп. – М.: МЕДпресс-информ, 2015. – Т. 1. [Shabalov NP. Neonatology. Study guide for students in 2 vol. 7th ed. Moscow: Medpress-inform; 2015. Vol. 1. (In Russ.)]
  • Shearer MJ. Vitamin K deficiency bleeding (VKDB) in early infancy. Blood Rev. 2009;23(2):49-59. doi: 10.1016/j.blre.2008.06.001.
  • Salomonsen L. On the prevention of hemorrhagic disease of the new-born by the administration of cow’s milk during the first two days of life. Acta Paediatr. 1940;28:1-7. doi: 10.1111/j.1651-2227.1940.tb15999.x.
  • Centers for Disease Control and Prevention (CDC). Notes from the field: late vitamin K deficiency bleeding in infants whose parents declined vitamin K prophylaxis. Tennessee, 2013. MMWR Morb Mortal Wkly Rep. 2013;62(45):901-902.
  • American Academy of Pediatrics, Committee on Nutrition. Vitamin K com- pounds and the water-soluble analogues: use in therapy and prophylaxis in pediatrics. Pediatrics. 1961;28:501-507.
  • McNinch AW, Tripp JH. Haemorrhagic disease of the newborn in the British Isles: two year prospective study. BMJ. 1991;303:1105-1109. doi: 10.1136/bmj.303.6810.1105.
  • Takahashi D, Shirahata A, Itoh S, et al. Vitamin K prophylaxis and late vitamin K deficiency bleeding in infants: fifth nationwide survey in Japan. Pediatr Int. 2011;53(6):897-901. doi: 10.1111/j.1442-200X.2011.03392.x.
  • Darlow BA, Phillips AA, Dickson NP. New Zealand surveillance of neonatal vitamin K deficiency bleeding (VKDB): 1998-2008. J Paediatr Child Health. 2011;47:460-464. doi: 10.1111/j.1440-1754.2010.01995.x.
  • McNinch A. Vitamin K deficiency bleeding: early history and recent trends in the United Kingdom. Early Hum Dev. 2010;86(Suppl.1):63-65. doi: 10.1016/j.earlhumdev.2010.01.017.
  • McNinch A, Busfield A, Tripp J. Vitamin K deficiency bleeding in Great Britain and Ireland: British Paediatric Surveillance Unit Surveys, 1993-94 and 2001-02. Arch Dis Child. 2007;92(9):759-66. doi: 10.1136/adc.2006.104752.
  • Stokowski LA. Reemergence of vitamin K deficiency bleeding. Adv Neonatal Care. 2014;14(2):75.
  • Obladen M. Innocent blood: a history of hemorrhagic disease of the new-born. Neonatology. 2015;107(3):206-212. doi: 10.1159/000369523.
  • Абезгауз А.М. Геморрагические заболевания у детей. – М.: Медицина, 1970. – 324 с. [Abezgauz AM. Hemorrhagic disease in children. Moscow: Medicine; 1970. 324 p. (In Russ.)]
  • Tollis D. Who were… Cheyne and Stokes? Nurs Times. 1995;91(14):40.
  • Lyons JB. John Cheyne’s classic monographs. J Hist Neurosci. 1995;4(1):27-35. doi: 10.1080/09647049509525624.
  • Sternbach GL. John Cheyne and William Stokes: periodic respiration. J Emerg Med. 1985;3(3):233-236. doi: 10.1016/0736-4679(85)90078-2.
  • Bendiner E. The Dublin school: from poverty, a rich legacy. Hosp Pract (Off Ed). 1984;19(6):221-247. doi: 10.1080/21548331.1984.11702853.
  • Grandidier L. Die Haemophilie oder die Bluterkrankheit. Wigand; 1855. 158 p.
  • Townsend CW. The haemorrhagic disease of the new-born. Arch Pediatr. 1894;11:559-565.
  • Dam H. The antihaemorrhagic vitamin of the chick. Biochem J. 1935;29(6):1273-85. doi: 10.1042/bj0291273.
  • Dam H, Lewis L. The chemical concentration of vitamin K. Biochem J. 1937;31(1):17-21.
  • Quick AJ. The thromboplastin reagent for the determination of prothrombin. Science. 1940;92(2379):113-4. doi: 10.1126/science.92.2379.113-a.
  • Quick AJ. Effect of synthetic vitamin K and of quinine sulfate on the pro-thrombin level. J Lab Clin Med. 1946;31:79-84.
  • Thayer SA, Maccorquodale DW, Binkley SB, Doisy EA. The isolation of a crystalline compound with vitamin k activity. Science. 1938;88(2280):243. doi: 10.1126/science.88.2280.243.
  • Lunin N. Über die Bedeutung der anorganischen Salze für die Ernährung des Thieres. Zeitschrift für Physiologische Chemie. 1881:5:31-39.
  • Мачабели М.С. Коагулопатические синдромы. – М.: Медицина, 1970. – 303 с. [Machabeli MS. Coagulopathies syndromes. Moscow: Medicine; 1970. 303 p. (In Russ.)]
  • Колесов Д.В. Устойчивая доминанта моего внутреннего мира (к 110-летию со дня рождения Ю.Ф. Домбровской). [Kolesov DV. Stable dominant of my inner world (to the 110 anniversary since the birth of the U.F. Dombrowskaya). (In Russ.)]. Доступно по: http://rl-online.ru/info/ authors/35.html.
  • Chuansumrit A, Isarangkura P, Hathirat P. Vitamin K Study Group. Vitamin K deficiency bleeding in Thailand: a 32-year history. Southeast Asian J Trop Med Public Health. 1998;29:649-654.
  • McNinch AW, Orme RLE, Tripp JH. Haemorrhagic di sease of the newborn returns. Lancet. 1983;1:1089-90. doi: 10.1016/S0140-6736(83)91921-9.
  • Lane PA, Hathaway WE. Vitamin K in infancy. J Pediatr. 1985;106:351-359. doi: 10.1016/S0022-3476(85)80656-9.

Supplementary files

There are no supplementary files to display.

Views

Abstract - 71

PDF (Russian) - 82


Copyright (c) 2017 Ivanov D.O.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.