Hygiene and SanitationHygiene and SanitationГигиена и санитария0016-99002412-0650Federal Scientific Center of Hygiene named after F.F. Erisman63823210.47470/0016-9900-2024-103-4-382-390ntnhrrPREVENTIVE TOXICOLOGY AND HYGIENIC STANDARTIZATIONПРОФИЛАКТИЧЕСКАЯ ТОКСИКОЛОГИЯ И ГИГИЕНИЧЕСКОЕ НОРМИРОВАНИЕMechanisms of physiological and toxic effects of lithium salts on the body (literature review)Механизмы физиологического и токсического действия солей лития на организм (обзор литературы)https://orcid.org/0000-0002-0545-631XGorokhovaLarisa G.ГороховаЛариса Геннадьевна
Russian Federation

MD, PhD, DSci., Leading researcher, Lab. molecular genetic and experimental research of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation; Associate Professor of the department of natural science disciplines of the Kuzbass Humanitarian-Pedagogical Institute of the Kemerovo State University, 654041, Novokuznetsk, Russian Federation

e-mail: ponomarikova@mail.ru

Канд. биол. наук, вед. науч. сотр. лаб. молекулярно-генетических и экспериментальных исследований ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия; доцент каф. естественнонаучных дисциплин Кузбасского гуманитарно-педагогического института ФГБОУ ВО «КГУ», 654041, Новокузнецк, Россия

e-mail: ponomarikova@mail.ru

ponomarikova@mail.ruhttps://orcid.org/0000-0002-4797-7842ZhukovaAnna G.ЖуковаАнна Геннадьевна
Russian Federation

MD, PhD, DSci., Associate Professor, Head of the Lab. of molecular genetics and experimental research of Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation, Head of the Department of natural science disciplines of the Kuzbass Humanitarian-Pedagogical Institute of the Kemerovo State University, 654041, Novokuznetsk, Russian Federation

Доктор биол. наук, доцент, зав. лаб. молекулярно-генетических и экспериментальных исследований ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия, зав. каф. естественнонаучных дисциплин Кузбасского гуманитарно-педагогического института ФГБОУ ВО «КГУ», 654041, Новокузнецк, Россия

https://orcid.org/0000-0002-1127-6980MikhailovaNadezhda N.МихайловаНадежда Николаевна
Russian Federation

MD, PhD, DSci., Professor, Chief researcher of the Lab. of molecular genetics and experimental research of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, 654041, Novokuznetsk, Russian Federation

Доктор биол. наук, профессор, гл. науч. сотр. лаб. молекулярно-генетических и экспериментальных исследований ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия

https://orcid.org/0000-0003-2512-2541KorsakovaTatyana G.КорсаковаТатьяна Георгиевна
Russian Federation

MD, PhD, leading researcher of the Lab. of Human Ecology and Environmental Hygiene of the Research Institute of Complex Problems of Hygiene and Occupational Diseases, Novokuznetsk, 654041, Russian Federation

e-mail: ecologia_nie@mail.ru

Канд. биол. наук, вед. науч. сотр. лаб. экологии человека и гигиены окружающей среды ФГБНУ «НИИ КПГПЗ», 654041, Новокузнецк, Россия

Research Institute for Complex Problems of Hygiene and Occupational DiseasesФГБНУ «Научно-исследовательский институт комплексных проблем гигиены и профессиональных заболеваний»Kuzbass Humanitarian and Pedagogical Institute of the “Kemerovo State University”Кузбасский гуманитарно-педагогический институт ФГБОУ ВО «Кемеровский государственный университет»22052024103438239025102024Copyright ©; 2024, Gorokhova L.G., Zhukova A.G., Mikhailova N.N., Korsakova T.G.Copyright ©; 2024, Горохова Л.Г., Жукова А.Г., Михайлова Н.Н., Корсакова Т.Г.2024Gorokhova L.G., Zhukova A.G., Mikhailova N.N., Korsakova T.G.Горохова Л.Г., Жукова А.Г., Михайлова Н.Н., Корсакова Т.Г.https://journals.eco-vector.com/0016-9900/article/view/638232

The study of the influence of various chemical elements on the human body is an important direction because it allows determining the patterns of the distribution and migration of these elements in tissues, as well as their role in the development of specific diseases. Among inorganic chemical compounds, a special place is occupied by lithium salts, which are widely used in industry, agriculture, and medicine. The search and selection of literature sources to identify the physiological effects and characteristics of the toxic effects of lithium salts on the human body and experimental animals was carried out using the bibliographic databases: Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, RSCI, Cyberleninka. Data analysis has showed lithium salts to be classified as moderately hazardous substances (hazard class 3) and in high concentrations have a damaging effect on the functions of the nervous system, kidneys, thyroid and parathyroid glands.

Contribution:Gorokhova L.G. — the concept of the study, collection of material, writing the text;Zhukova A.G. — collection of material, writing the text;Mikhailova N.N. — editing;Korsakova T.G. — collection of material.All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship.

Received: February 15, 2024 / Revised: March 11, 2024 / Accepted: April 9, 2024 / Published: May 8, 2024

Изучение влияния различных химических элементов на организм человека является актуальным направлением, поскольку позволяет определять закономерности распределения и миграции этих элементов в тканях, а также их роль в развитии специфических патологий. Среди неорганических химических соединений особое место занимают литиевые соли, которые широко применяются в промышленности, сельском хозяйстве и медицине. Поиск и отбор литературных источников для выявления физиологических эффектов и особенностей токсического действия солей лития на организм человека и экспериментальных животных осуществлён с использованием библиографических баз данных Scopus, MedLine, Web of Science, PubMed, The Cochrane Library, РИНЦ, Cyberleninka. Анализ данных показал, что соли лития относятся к умеренно опасным веществам (III класс опасности) и в высоких концентрациях оказывают повреждающее действие на функции нервной системы, почек, щитовидной и паращитовидных желёз.

Участие авторов:Горохова Л.Г. — концепция исследования, сбор материала, написание текста;Жукова А.Г. — сбор материала, написание текста;Михайлова Н.Н. — редактирование;Корсакова Т.Г. — сбор материала.Все соавторы — утверждение окончательного варианта статьи, ответственность за целостность всех частей статьи.

Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов в связи с публикацией данной статьи.

Финансирование. Исследование не имело спонсорской поддержки.

Поступила: 15.12.2023 / Поступила после доработки: 11.03.2024 / Принята к печати: 09.04.2024 / Опубликована: 08.05.2024

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