Introduction. Optimal aeration regime and hygienic standards for the content ingredients in the air of pedestrian pavements and public spaces in close contact with traffic flows on the street and road networks of cities in different climatic regions are ensured by selecting the most rational urban planning solutions in the routing, layout, development. and landscaping of transport communications.Materials and methods. Wind speed measurement, air sampling and chemical analysis of air samples on main street sections in large cities according to commonly accepted methods.Results. Regularities of wind speed transformation and formation of concentration of toxic impurities in the air on urban streets have been established. Optimal variants on layout and landscaping of transport communications for formation of optimal aeration regime and protection of pedestrian zones and public spaces from gassiness are identified. Limitations. The problem statement and choice of research objects are limited to the study of wind speed distribution and concentrations of toxic ingredients in the air of main streets of citywide and district significance.Conclusions. Urban planning measures to form a comfortable aeration regime and ensure high quality of atmospheric air include selection of the route direction taking into account the wind rose, dimensions of the cross profile and optimal planning and design solutions for the development and landscaping of urban roads and streets. The maximum reduction in the concentration of toxic impurities on streets with frontal building occurs at the height of woody plants at the level of the middle of building facades. On the streets of small width with two-sided dense building, comfortable aeration regime and minimum concentrations of ingredients are noted at the formation of landscaping strips of blown structure.Compliance with ethical standards. The study does not require the submission of the conclusion of the Biomedical ethics committee or other documents.Contribution: Balakin V.V. – the concept and design of the study, collection and processing of material, statistical processing, writing a text; Aleksikov S.V. – the concept and design of the study, editing; Chesnokova O.G. – collection and processing of material, editing. All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.Conflict of interest. The authors declare no conflict of interest.Acknowledgement. The study had no sponsorship.Received: September 4, 2024 / Revised: November 11, 2024 / Accepted: December 3, 2025 / Published: April 30, 2025