Introduction. In the Russian Federation, diseases of the circulatory system are leading in the structure of the common incidence and mortality in the adult population, and since 2008, they have also been the leading causes of death among the employable age population. Reducing mortality among the employable age population and mortality from diseases of the circulatory system are the most important target indices of the national project “Healthcare”.Materials and methods. Life expectancy was calculated using an indirect (demographic) method, the contribution of mortality from diseases of the circulatory system by age groups to the differences in life expectancy of men in Kuzbass and subjects of the Russian Federation, and elimination reserves of life expectancy were calculated based on the component method. The age-related mortality rates of the Russian Fertility and Mortality Database were used. To identify the incidence of atherosclerosis of the main arteries, 610 patients aged 47.003±4.875 years were examined.Results. Mortality in Kuzbass men from diseases of the circulatory system is higher in all age groups compared to the Russian Federation, except for 20–29 years. In 2022, the difference in life expectancy with the Russian Federation is 3.30 years, of which 0.79 years is the contribution of diseases of the circulatory system (0.23 years – ischemic heart disease, 0.32 years – cerebrovascular diseases). The elimination reserve associated with the exclusion of mortality from diseases of the circulatory system is 5.78 years. In a random sample, we found a high occurrence of asymptomatic atherosclerosis in men of employable age (61.35%). Arterial hypertension as one of the leading risk factors for the development of atherosclerosis was revealed in almost half of the examined individuals (43.2%).Limitations of the study are related to the duration of the preventive medical examination.Conclusion. Regional features of the life expectancy of Kuzbass men and the impact of mortality from circulatory system diseases, a significant proportion of which is associated with atherosclerosis, have been identified. The elimination of mortality from diseases of the circulatory system promotes an increase in the life expectancy of Kuzbass men by 5.78 years.Compliance with ethical standards. In accordance with the Declaration of Helsinki of the World Medical Association (2013 edition), all subjects read and signed informed consent to participate in the study, the protocol of which met the requirements of the Bioethics Committee of the Federal State Budgetary Scientific Institution “Research Institute for Complex Problems of Hygiene and Occupational Diseases” (Protocol of Meeting No. 4, § 1 dated November 18, 2021). All participants gave informed voluntary written consent to participate in the study.Contribution: Korotenko O.Yu. – concept and design of the study, collection of material, writing the text; Baran O.I. – data analysis, writing the text. All co-authors – approval of the final version of the article, responsibility for the integrity of all parts of the article.Conflict of interest. The authors declare no conflict of interest.Funding. The study had no sponsorship.Received: June 25, 2025 / Revised: July 14, 2025 / Accepted: July 15, 2025 / Published: August 20, 2025