PrirodaPrirodaПрирода0032-874XAkademizdatcenter Nauka62777810.7868/S0032874X23020011ArticlesСтатьиResearch ArticleAntidepressant Resistance: Why It Occurs and What to Do About It?Устойчивость к антидепрессантам: почему возникает и что с этим делать?TsybkoA. SЦыбкоА. Сantoncybko@mail.ruInstitute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesИнститут цитологии и генетики СО РАН280220232NO ()№ (2)31501032024Copyright ©; 1970, Издательство «Наука»1970Издательство «Наука»https://journals.eco-vector.com/0032-874X/article/view/627778

Antidepressant resistance poses one of the biggest challenges to modern neuropharmacology. Here we will try to consider the problem in terms of the serotonin system. What are its features and how can they cause therapeutic resistance? In addition, special attention will be paid to serotonin receptors, whose amazing biology not only shed light on the mechanisms of depressive disorders, but also promise to provide the key to the effective therapy of the latters.

Устойчивость к антидепрессантам — один из самых больших вызовов для современной нейрофармакологии. В статье предлагается взглянуть на проблему с точки зрения серотониновой системы. Каковы ее особенности и как они могут обуславливать терапевтическую резистентность? Кроме того, отдельное внимание уделено рецепторам серотонина, удивительная биология которых не только проливает свет на механизмы депрессивных расстройств, но и обещает дать ключ к их эффективной терапии.

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