Email this article A role of the body's antioxidativedefense system in the pathogenesis of acute viral hepatitides
- Authors: Nagoev BS1, Ivanovo MR1
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Affiliations:
- Issue: Vol 78, No 11 (2003)
- Pages: 15-16
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29682
- ID: 29682
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Abstract
Aim. To study the activity of antioxidative defense enzymes and the total plasma antioxidative activity
in patients with viral hepatitis B, C, and mixed hepatitis В + С.
Materials and methods. 77 patients with viral hepatitis B, 90 with viral hepatitis C, and 25 with
mixed hepatitis В + С were followed up. The activity of superoxide dismutase and catalase of leukocytes, and the total plasma antioxidative activity were determined at the peak of the disease, allevia-
tion of clinical symptoms, and before discharge from hospital.
Results. At the peak of the disease, the patients with viral hepatitides showed suppressed activities of
superoxide dismutase and catalase of leukocytes and suppressed total plasma antioxidative activity
with increased these parameters by early convalescence, but without their normalization. There were
the most pronounced changes in patients with severe mixed hepatitis В + С.
Conclusion. The changes found in the body's antioxidative defense have been ascertained to depend
on the etiology, stage, and severity of viral hepatitis.
in patients with viral hepatitis B, C, and mixed hepatitis В + С.
Materials and methods. 77 patients with viral hepatitis B, 90 with viral hepatitis C, and 25 with
mixed hepatitis В + С were followed up. The activity of superoxide dismutase and catalase of leukocytes, and the total plasma antioxidative activity were determined at the peak of the disease, allevia-
tion of clinical symptoms, and before discharge from hospital.
Results. At the peak of the disease, the patients with viral hepatitides showed suppressed activities of
superoxide dismutase and catalase of leukocytes and suppressed total plasma antioxidative activity
with increased these parameters by early convalescence, but without their normalization. There were
the most pronounced changes in patients with severe mixed hepatitis В + С.
Conclusion. The changes found in the body's antioxidative defense have been ascertained to depend
on the etiology, stage, and severity of viral hepatitis.
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