Email this article Ethnic differences in apolipoprotein В levels in hyperlipidemia in Russians and the Kirghiz
- Authors: Mirrakhimov EM1, Noruzbaeva AM1, Lunegova OS1, Afanasyeva MI1, Adamova IY.1, Pokrovsky SN1, Poroschai EN1, Mirrakhimov MM1
-
Affiliations:
- Issue: Vol 79, No 6 (2004)
- Pages: 35-39
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29827
- ID: 29827
Cite item
Full Text
Abstract
Material and methods. Lipid spectrum of the blood (LDLP and HDLP cholesterol, total cholesterol, triglicerides), apo-B, CHD risk factors were studied in 60 Russian and 75 Kirghis patients with PHL aged 28 to 67years (mean age 50.0 + 7.59 years, 56females and 79 males). Results. In Russians a mean level of LDLP cholesterol and apo-B was significantly higher than in Kirghiz patients (3.95 + 1.29 mmol/l vs 3.51+1.17 mmol/l, p = 0.042; 173.3+ 57.3 mg/dl vs 145.5 + 49.3 mg/dl, p = 0.003, respectively). CHD in both ethnic groups occurred with similar rates. The multifactorial regression analysis shows that an apo-B concentration can serve an independent risk factor associated with CHD in the Kirghiz population (p = 0.25, p = 0.03) while in Russians living in Kirghizia this factor is a low content of HDLP cholesterol (p = -0.25, p = 0.05).
About the authors
E M Mirrakhimov
A M Noruzbaeva
O S Lunegova
M I Afanasyeva
I Yu Adamova
S N Pokrovsky
E N Poroschai
M M Mirrakhimov
References
- Clark L. Т., Ferdinand К. С., Flack J. M. et al. Coronary heart disease in African Americans. Heart Dis. 2001; 3: 97-108.
- Howard B. V., Lee E. Т., Cowan L. D. et al. Coronary heart disease prevalence and its relation to risk factors in American Indians: the Strong Heart Study. Am. J. Epidemiol. 1995; 142: 254-268.
- Wei M., Mitchell В. D., Haffiter S. M., Stern M. P. Effects of cigarette smoking, diabetes, high cholesterol, and hypertension on all-cause mortality and cardiovascular disease mortality in Mexican Americans: the San Antonio Heart Study. Am. J. Epidemiol. 1996; 144: 1058-1065.
- Enas E. A., Yusuf S., Sharma S. Coronary artery disease in South Asians', second meeting of the International Working Group. Indian Heart J. 1998; 50: 105-113.
- Abbot R. D., Sharp D. S., Burchifiel С. М. et al. Cross-sectional and longitudinal changes in total and high density-lipoprotein cholesterol levels over 20-year period in elderly men: the Honolulu Heart Program. Ann. Epidemiol. 1997; 7: 417-424.
- Айтбаев К. А., Мейманалиев Т. С., Шлейфер Е. А. и др. Питание и распространенность ИБС и факторов ее риска среди мужчин 20-59 лет. Волр. питания 1988; 4: 28-32.
- Expert panel on detection, evaluation and treatment of high blood cholesterol in adults ATP HI. J. A. M. A. 2001; 285: 2486-2497.
- Reinhart R. A., Gani K., Arndt M. R. et al. Apolipoprotein A-I and В as predictors of angiographically defined coronary artery disease. Arch. Intern. Med. 1990; 150: 1629-1633.
- Levinson S. S., Wagner S. G. Measurement of apoliprotein Bcontaining lipoproteins for routine clinical laboratory use in cardiovascular disease. Arch. Pathol. Lab. Med. 1992; 116 (12): 1350-1354.
- al-Kateb H., Zarzzour W., Shameah M., Juoma M. Coronary risk factors of angiographically assessed patients from Syria. J. Cardiovasc. Risk 1998; 5 (1): 31-35.
- Lynch J., Marshall M. D., Wang W. X. et al. Apolipoprotein screening in Australian children: feasibility and the effect of age, sex, and ethnicity. Med. J. Aust. 1998; 68: 61-64.
- Fong P. C., Tarn S. C., Tai Y. T. et al. Serum lipid and apolipoprotein distributions in Hong Kong. Chin. J. Epidemiol. Commun. Hlth 1994; 48 (4): 355-359.
- Lamarche В., Moorjani S., Lupien P. J. et al. Apolipoprotein A-I and В levels and risk of ischemic heart disease during a five-year follow-up of men in the Quebec Cardiovascular Study. Circulation 1996; 94: 273-278.
- Джолдасбекова А. У., Рысмендиев А. Ж., Байтасова Н. Б., Шуратова С. Г. Состояние перекисного окисления липидов и антиоксидантной систем у больных ИБС уйгурской национальности. Здравоохр. Казахстана 1997; 1: 14-25.
Supplementary files
