Epidemiology of chronic renal disease in the Northwest of Russia: setting-up the register
- Authors: Dobronravov VA1, Smirnov AV1, Dragunov SV1, Zverkov RV1, Evdokimova TV1, Butrimova SS.1, Grigorschuk VI1
-
Affiliations:
- Issue: Vol 79, No 9 (2004)
- Pages: 57-61
- Section: Editorial
- Submitted: 09.04.2020
- Published: 15.09.2004
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29911
- ID: 29911
Cite item
Full Text
Abstract
Federation.
Material and methods. A population retrospective trial was performed from 01.07.98 to 30.06.99 in
the Vologda region, towns Veliky Novgorod and Syktyvkar (total population 1840000). 490 cases of
chronic renal failure (CRF) with creatinin levels > 300 mcmol/l corresponding to CRD stage IV and
V by glomerular filtration rate were detected. CRD stage IV-V prevalence, morbidity including sexand age-specific parameters, cumulative survival in different etiology of CRD regarding replacement
therapy (RT) and nephrologist supervision were estimated.
Results. Mean prevalence and morbidity were 266 and 108 cases per million. Number of affected
males and females was the same. CRD was provoked by chronic glomerulonephritis (CGN) - 41%,
chronic interstitional nephritis - 16%, diabetes mellitus - 14%, renal polycystic disease - 8%, amyloidosis - 6%, hypertension nephrosclerosis - 2%, other causes - 3%, cases of unclear etiology 10%. Among patients with primary renal pathology on RT, number of CGN patients was higher 61% while diabetic and amyloidosis shares were much lower 1.6 and 0.8%. 31.1% patients given no
RT had Cr > 500 mcmol/l and glomerular filtration rate < 10 ml/min. Incidence of CRD stage IV- V
in RT patients was 80 per million, 8 patients per million for I year started RT for the first time. CRF
mortality was 85 patients per million a year. 88.4% of deaths in patients given no RT was due to uremia. Cumulative survival for RT patients and RT untreated was 90 and 50% a year, respectively.
Survival of the RT untreated observed by the nephrologist was significantly higher (p = 0.003).
Conclusion. New cases of CRD stage IV- V were comparable in number to European incidence rate
while prevalence was much less because of lower number of old patients and RT treated. The problem
of CRD treatment is urgent for RF and requires updating nephrological service and development ofRT
programs.
About the authors
V A Dobronravov
A V Smirnov
S V Dragunov
R V Zverkov
T V Evdokimova
S Sh Butrimova
V I Grigorschuk
References
- Anonimous. Part 1. Executive summary. Am. J. Kidney Dis. 2002; 39 (suppl. 1): S17-S31.
- Jones С A., McQuillan G. M., Kusek J. W. et al. Serum creatinine levels in the US population. Third National Health and Nutrition Examination Survey. Am. J. Kidney Dis. 1998; 32: 992-999.
- Sarnak M. J., Levey A. S. Cardiovascular disease and chronic renal disease: A new paradigm. Am. J. Kidney Dis. 2000; 35 (suppl. 1): S117-S131.
- Excerpts from United States Renal Data System. 1999 Annual Data Report. Am. J. Kidney Dis. 1999; 34 (suppl. 1): S10- S176.
- Berthoux F., Jones E., Gellert R. et al. Epidemiological data of treated end-stage renal failure in the European Union (EU) during the year 1995: report of the European Renal Associa tion Registry and the National Registries. Nephroi. Dial. Transplant. 1999; 14 (10): 2332-2342.
- Schena F. P. Epidemiology of end-stage renal disease: International comparisons of renal replacement therapy. Kidney Int. 2000; 57 (suppl. 74): S39-S45.
- Locatelli F, Del Vecchio L., Pozzoni P. The importance of early detection of chronic kidney disease. Nephrol. Dial. Transplant. 2002; 17 (suppl. 11): 2-7.
- К проблеме лечения терминальной хронической почечной недостаточности в России. Первые итоги работы по созданию Российского национального регистра заместительной почечной терапии. Нефрол. и диализ 1999; 1 (I): 79-84.
- Флетчер Р., Флетчер С, Вагнер Э. Клиническая эпидемиология. Основы доказательной медицины. М.: Медиа Сфера; 1998.
- Jungers P., Chauveau P., Descamps-Latscha В. et al. Age and gender-related incidence of chronic renal failure in a French urban area: a prospective epidemiologic study. Nephrol. Dial. Transplant. 1996; 11: 1542-1546.
- Feest T. G., Mistry С D., Grimes D. S. et al. Incidence of ad vanced chronic renal failure and the need for end stage renal replacement treatment. Br. Med. J. 1990; 301: 897-900.
- Locatelli F, D'Amico M., Cemevskis H. et al. The epidemiology of end-stage renal disease in the Baltic countries: an evolving picture. Nephrol. Dial. Transplant. 2001; 16: 1338-1342.
- Rutkowski B. Changing pattern of end-stage renal disease in central and eastern Europe. Nephrol. Dial. Transplant. 2000; 15: 156-160.
- Culleton B. F., Larson M. G., Wilson P. W. F. et al. Cardiovascular disease and mortality in a community-based cohort with mild renal insufficiency. Kidney Int. 1999; 56 (6): 2214-2219.
- lungers P., Choukroun G., Robino С. et al. Epidemiology of endstage renal disease in the Ile-de-France area: a prospective study in 1998. Nephrol. Dial. Transplant. 2000; 15 (12): 2000-2006.
- Roubicek C, Brunet P., Huiart L. et al. Timing of nephrology referral: influence of mortality and morbidity. Am. J. Kidney Dis. 2001; 36: 35-41.
- McLaughlin К., Manns В., Culleton В. et al. Ал economic evaluation of early versus late referral of patients with progressive renal insufficiency. Am. J. Kidney Dis. 2001; 38: 1122-1128.
- Maiorca R. Ethical problems in dialysis: prospects for the year 2000. Nephrol. Dial. Transplant. 1998; 13: 1.