Email this article Immunological features of rheumatoid arthritis in patients infected withviruses of hepatitis В, С and cryoglobulinemia
- Authors: Balabanova RM1, Shekshina ЕV1, Kozlov LV1
-
Affiliations:
- Issue: Vol 79, No 11 (2004)
- Pages: 74-77
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29963
- ID: 29963
Cite item
Full Text
Abstract
Aim. To specify immunological features of rheumatoid arthritis (RA) associated with hepatitis В, С viruses
(HBV, HCV) and cryoglobulinemia (CGE).
Material and methods. Four groups of patients with verified RA were examined immunologically: infected
with HCV, infected with HBV, with CGE diagnosed by the capillary method, free of HBV,
HCV, CGE. CGE was estimated by the spectrophotometry method, functional activity of the complement
components - by hemolytic micromethod. Polymerase chain reaction, identification of serological
markers of viral hepatitides В and С were conducted with application of commercial kits produced
in Russia
Results. In RA patients infected with HBV and HCV, functional activity of the complement was significantly
reduced. RA patients with hepatitis С and CGE showed hypoactivity of all the complement
components. A classic course of RA was associated with elevated levels of CI and C3 components in
normal values of Clq, C2, C4 and C5 components. CGE was highest in RA+HCV and RA+CGE
groups.
Conclusion. The study of immunological features of RA associated with HCV, HBV and CGE is important
not only in scientific but also in practical aspect as it indicates the necessity of treating the
above conditions with drugs which do not suppress complement system significantly.
(HBV, HCV) and cryoglobulinemia (CGE).
Material and methods. Four groups of patients with verified RA were examined immunologically: infected
with HCV, infected with HBV, with CGE diagnosed by the capillary method, free of HBV,
HCV, CGE. CGE was estimated by the spectrophotometry method, functional activity of the complement
components - by hemolytic micromethod. Polymerase chain reaction, identification of serological
markers of viral hepatitides В and С were conducted with application of commercial kits produced
in Russia
Results. In RA patients infected with HBV and HCV, functional activity of the complement was significantly
reduced. RA patients with hepatitis С and CGE showed hypoactivity of all the complement
components. A classic course of RA was associated with elevated levels of CI and C3 components in
normal values of Clq, C2, C4 and C5 components. CGE was highest in RA+HCV and RA+CGE
groups.
Conclusion. The study of immunological features of RA associated with HCV, HBV and CGE is important
not only in scientific but also in practical aspect as it indicates the necessity of treating the
above conditions with drugs which do not suppress complement system significantly.
References
- Балабанова Р. М. Ревматоидный артрит. В кн: Насонова В. А., Бунчук Н. В. (ред.) Ревматические болезни. М.: Медицина; 1997. 257-295.
- Чичасова Н. В. Ревматоидный артрит: клинико-иммунологические и клинико-морфологические сопоставления, прогноз: Дис. ... д-ра мед. наук. М.; 2000. 61-102.
- Кашкин К. П., Кубась В. Г. Система комплемента и ее активность. Иммунология 1981; 1: 27-35.
- Козлов Л. В. Белки системы комплемента. В кн: Иванов В. Т. (ред.) Белки и пептиды. М.: Наука; 1995. 121 - 138.
- Соловьев С. К., Иванова М. М. Экстравысокие (ударные) дозы метилпреднизолона при волчаночном нефрите. Тер. арх. 1980; 4: 121-123.
- Peters D. К., Martin A., Weinstein A. et al. Complement studies in membrano-proliferative glomerulonephritis. Clin. Exp. Immunol. 1972; 50: 433-464.
- Матвеевская N. С. Получение иммунохимических реагентов для определения компонентов СЗ, С4, С5 комплемента человека и некоторые аспекты их клинического определения: Дис. ... канд. биол. наук. М.; 1995.
- Горячев Д. В. Влияние интерферона-а 2Ь (реальдирона) на функциональную активность компонентов комплемента и интерфероновый статус при ревматоидном артрите: Автореф. дис. ... канд. мед. наук. М.; 1999.
- Козлов Л. В., Вавилова Л. М., Голосова Т. В. Микрометод определения факторов комплемента. М.; 1994. 66-68.
- Братских Е. В., Козлов Л. В., Мишин А. А., Балабанова Р. М. Функциональная активность компонентов комплемента при ревматоидном артрите с криоглобулинемией, ассоциированной с вирусами гепатита В, С. Аллергол. и иммунол. 2001; 2 (2: Тезисы IV Съезда иммунологов и аллергологов СНГ): 23.
- Козлов Л. В., Кудряшова Л. П., Иванова И. В. Система комплемента больных ревматоидным артритом в зависимости от проводимой лекарственной терапии. Клин. мед. 1994; 5: 43-47.
- Amett F. С., Edworthy S., Block D. A. et al. The 1987 reserved ARA criteria for rheumatoid arthritis. Arthr. and Rheum. 1987- 30: S 70.
- Насонова В. А., Астапенко М. Г. Ревматоидный артрит. В кн.: Клиническая ревматология. М.: Медицина; 1989 281-285.
- Wilke W., Sweeney Т., Calabrese L. Early aggressive therapy for rheumathoid arthritis: concerns, descriptions and estimate of outcome. Semin. Arthr. Rheum. 1993; 23 (2): 26-41.
- Prevoo M. L. L., van Hof M. A., Kuper H. H. et al. Modified disease activity scores that include twenty-eight-joint counts. Arthr. and Rheum. 1995; 38: 44-48.
- Van der Heijde D. M. F. M. , van Hof M. A., van Riel P. L. С. М. et al. Vadility of single variables and composite indices for measuring disease activity in rheumatoid arthritis. Ann. Rheum. Dis. 1992; 51: 177-181.
- Steinbrocker 0., Traeger С. Н. et al. Therapeutic criteria in rheumatoid arthritis. J. A. M. A. 1949; 140 (8): 659-662.
- Константинова H. А. Криоглобулины и патология. М.: Медицина; 1999.
- Насонов Е. Л., Баранов А. А., Шилкина Н. П. Васкулиты и васкулопатии. Ярославль: Верхняя Волга; 1999. 515-520
Supplementary files
