Email this article Combined basic therapy of rheumatoid arthritis with methotrexate and plaquenil
- Authors: Sergiets NA1, Erov NK1, Sergiets NA1, Erov NK1
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- Issue: Vol 81, No 6 (2009)
- Pages: 34-36
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30357
- ID: 30357
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Abstract
Aim. To compare efficacy of basic RA treatment with methotrexate+plaquenil and basic monotherapy with methotrexate.
Material and methods. Two groups of rheumatoid arthritis (RA) patients were studied: group 1 (n = 82) received combined basic treatment with methotrexate (7.5 mg/week) in combination with plaquenil (0.2 ?mg/day); group 2 (n = 60) received methotrexate monotherapy according to the same scheme; all the patients received also diclofenak in a dose 100 mg/day; low-dose glucocorticosteroids were given to 36 and 24 patients, respectively. To improve methotrexate tolerance, all the patients took folic acid (1-2 mg/day 5 days a week). Efficacy of the treatment was evaluated by regression and final value of inflammation activity.
Results. 6-month treatment produced in groups 1 and 2 good effect in 27.6 and 21.4%, satisfactory effect - in 65.5 and 66.6% patients, respectively. No effect was seen in 6.8 and 11.9% patients, respectively. A good effect was achieved in group 1 in 73.3 ± 5.4 days; in group 2 - in 93.7 ± 5.9 days (p < 0.05). In 12 months good and satisfactory effects persisted. Side effects occurred with the same frequency in both groups primarily in those who did not take folic acid.
Conclusion. Combined basic therapy of RA with methotrexate and plaquenil was more effective than monotherapy with methotrexate because it produced good effects more frequently and earlier while no response was seen less often.
Material and methods. Two groups of rheumatoid arthritis (RA) patients were studied: group 1 (n = 82) received combined basic treatment with methotrexate (7.5 mg/week) in combination with plaquenil (0.2 ?mg/day); group 2 (n = 60) received methotrexate monotherapy according to the same scheme; all the patients received also diclofenak in a dose 100 mg/day; low-dose glucocorticosteroids were given to 36 and 24 patients, respectively. To improve methotrexate tolerance, all the patients took folic acid (1-2 mg/day 5 days a week). Efficacy of the treatment was evaluated by regression and final value of inflammation activity.
Results. 6-month treatment produced in groups 1 and 2 good effect in 27.6 and 21.4%, satisfactory effect - in 65.5 and 66.6% patients, respectively. No effect was seen in 6.8 and 11.9% patients, respectively. A good effect was achieved in group 1 in 73.3 ± 5.4 days; in group 2 - in 93.7 ± 5.9 days (p < 0.05). In 12 months good and satisfactory effects persisted. Side effects occurred with the same frequency in both groups primarily in those who did not take folic acid.
Conclusion. Combined basic therapy of RA with methotrexate and plaquenil was more effective than monotherapy with methotrexate because it produced good effects more frequently and earlier while no response was seen less often.
References
- Насонов Е. Л. Фармакотерапия ревматоидного артрита - современные рекомендации. Врач 2007; 1: 38-42.
- Насонов Е. Л. Фармакотерапия ревматоидного артрита в эру генно-инженерных биологических препаратов. Тер. арх. 2007; 5: 5-8.
- Насонов Е. Л., Каратаев Д. Е., Чичасова Н. В., Чемерис Н. А. Современные стандарты фармакотерапии ревматоидного артрита. Клин. фармакол. и тер. 2005; 1: 72-75.
- Каратеев Д. Е. Современная медикаментозная терапия ревматоидного артрита. Лечащий врач 2007; 2: 40-46.
- Gorkoop-Ruiterman Y. P., de Vries-Bouwstra J. K., Allaart C. F. et al. Comparison of treatment strategies in early rheumatoid arthritis: a randomized trial. Ann. Intern. Med. 2007; 146 (6): 406-415.
- Насонов Е. Л. Ранняя диагностика и фармакотерапия ревматоидного артрита. Врач 2002; 2: 3-7.
- Олюнин Ю. А., Балабанова Р. М. Определение активности ревматоидного артрита в клинической практике. Тер. арх. 2005; 5: 23-26.
- O'Dell J. R., Leff R., Paulsen G. et al. Treatment of rheumatoid arthritis with methotrexate and hydroixichloroquine, methotrexate and sulfasalazine, or a combination of three medications. Arthr. and Rheum. 2002; 46 (5): 1164-1170.
- Симонова О. В., Немцов Б. Ф. Комбинированная терапия метотрексатом и преднизолоном при ревматоидном артрите. Казан. мед. журн. 2004; 4: 245-249.
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