Email this article Determinants for iron overload in patients with acute leukemias and aplastic anemia
- Authors: Makeshova AB1, Levina AA1, Mamukova Y.I1, Tsibulskaya MM1, Makarova PM1, Romanova EA1, Fevraleva IS1, Sudarikov AB1, Golovkina LL1, Stremoukhova AG1, Parovichnikova EN1, Savchenko VG1
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Affiliations:
- Hematology Research Center, Moscow
- Issue: Vol 82, No 7 (2010)
- Pages: 26-29
- Section: Editorial
- Submitted: 09.04.2020
- Published: 15.07.2010
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30605
- ID: 30605
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Abstract
Subjects and methods. The investigation included 104 patients, including 64 with various types of AL, 31 with AA, and 9 with myelodysplastic syndromes (MDS). A group affiliation and an erythrocyte phenotype were determined from rhesus system antigens in all the patients and the HFE gene was studied to identify mutations. For control of siderosis, the authors determined serum iron (SI) by a colorimetric technique, by applying the kits of the AGAT firm (Russia), serum ferritin (SF) by an immunoradiometric method, by using the kits of Immunotech (Czechia). The volume of transfusion was estimated in the period of June 2007 to November 2009.
Results. There is evidence for a relationship between the higher level of SF and the number of transfusions. SF was 1046.1 μg/l in patients, H63D heterozygous carriers who had received less than 10 packed red blood cell transfusions and 2856 μg/l in those who had 20 transfusions (p < 0.005). HFE gene mutation carriage accelerates iron accumulation and is an additional risk factor for siderosis. In patients with transfusion chimeras and a rare phenotype in terms of rhesus antigens, packed red blood cell transfusion results in a much more increase in iron stores.
Conclusion. The most important factor of iron overload acceleration is no specific choice of packed red blood cells for patients with rare combinations of red blood cell antigens and for those with artificially induced chimeras.
About the authors
A B Makeshova
Hematology Research Center, Moscow
Email: ainuramak@mail.ru
Hematology Research Center, Moscow
A A Levina
Hematology Research Center, Moscow
Email: yullevina@yandex.ru
Hematology Research Center, Moscow
Yu I Mamukova
Hematology Research Center, Moscow
Email: hloe@rambler.ru
Hematology Research Center, Moscow
M M Tsibulskaya
Hematology Research Center, MoscowHematology Research Center, Moscow
P M Makarova
Hematology Research Center, MoscowHematology Research Center, Moscow
E A Romanova
Hematology Research Center, MoscowHematology Research Center, Moscow
I S Fevraleva
Hematology Research Center, MoscowHematology Research Center, Moscow
A B Sudarikov
Hematology Research Center, MoscowHematology Research Center, Moscow
L L Golovkina
Hematology Research Center, MoscowHematology Research Center, Moscow
A G Stremoukhova
Hematology Research Center, MoscowHematology Research Center, Moscow
E N Parovichnikova
Hematology Research Center, MoscowHematology Research Center, Moscow
V G Savchenko
Hematology Research Center, MoscowHematology Research Center, Moscow
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