Association of the serum level of apolipoprotein E with coronary artery disease and carotid artery atherosclerosis in Kyrgyz men with dyslipidemia
- Authors: Lunegova O.S.1, Pavlenko M.A.1, Kerimkulova A.S.1, Noruzbaeva A.M.1, Samanchina B.T.1, Zalesskaya Y.V.1, Abilova S.S.1, Mirrakhimov A.E.1, Moldokeeva C.B.1, Mirrakhimov EM1, Lunegova OS1, Pavlenko MA1, Kerimkulova AS1, Noruzbayeva AM1, Samanchina BT1, Zalesskaya Y.V1, Abilova SS1, Mirrakhimov AE1, Moldokeyeva C.B1, Mirrakhimov EM1
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Affiliations:
- Issue: Vol 82, No 9 (2010)
- Pages: 18-23
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30637
- ID: 30637
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Abstract
Subjects and methods. One hundred and three Kyrgyz men, including 48 with CHD and 55 without this disease, were examined. A clinical examination was performed and blood lipid composition and serum glucose and apo-E levels were determined. The diagnosis of CHD was established in accordance with the conventional criteria. Whether atherosclerosis was present was determined by ultrasound duplex scanning.
Results. Low serum apo-E concentrations were associated with the presence of obesity, the higher blood levels of glucose and triglycerides. There was no correlation with other lipid metabolic parameters and the presence of CHD. A nonlinear relationship was noted between serum apo-E levels and CA atherosclerotic lesion, which was more frequently observed in patients with the apo-E level in the lower and upper quartiles.
Conclusion. Low serum apo-E content is a poor factor and associated with obesity, hypertriglyceridemia, elevated serum glucose levels, and the development of CA atherosclerosis.
About the authors
Ol'ga Sergeevna Lunegova
Email: lunegovaolga@mail.ru
Magdalena Andreevna Pavlenko
Alina Suyyunbekovna Kerimkulova
Email: alinakg@gmail.com
Aygul' Mukashevna Noruzbaeva
Email: nozurbaeva@mail.ru
Bermet Tazabekovna Samanchina
Yuliana Vladimirovna Zalesskaya
Email: jzalesskaya@mail.ru
Saamay Sagymbaevna Abilova
Email: abilova_s@mail.ru
Aybek Erkiovich Mirrakhimov
Cholpon Bolotbekovna Moldokeeva
Email: chopenka@mail.ru
E M Mirrakhimov
Email: ermir@infotel.kg
O S Lunegova
M A Pavlenko
A S Kerimkulova
A M Noruzbayeva
B T Samanchina
Yu V Zalesskaya
S S Abilova
A E Mirrakhimov
Ch B Moldokeyeva
E M Mirrakhimov
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