Age-specific features of acute myeloid leukemia karyotype
- Authors: Gritsaev S.V.1, Martynkevich I.S.1, Martynenko L.S.1, Ivanova M.P.1, Aksenova V.Y.1, Moskalenko M.V.1, Zapreeva I.M.1, Abdulkadyrov K.M.1, Gritsaev SV2, Martynkevich IS2, Martynenko LS2, Ivanova MP2, Aksenova VY.2, Moskalenko MV2, Zapreeva IM2, Abdulkadyrov KM2, Tiranova S.A.1
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Affiliations:
- Russian Research Institute of Hematology and Transfusiology, St-Petersburg
- Issue: Vol 83, No 1 (2011)
- Pages: 51-55
- Section: Editorial
- Submitted: 10.04.2020
- Published: 15.01.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30791
- ID: 30791
Cite item
Full Text
Abstract
Material and methods. Distribution of balanced, normal, unbalanced, complex and monosomic
karyotype among 244 patients with de novo AML in age groups 16-20, 21-30, 31-40, 41-50, 51-60, 61 and older was analysed.
Results. There is difference in frequency of balanced and complex karyotype in patients under and over 60 years. Number of AML patients with balanced aberrations including favourable variants t(8;21), t(15;17) and inv(16) falls after 60 years of age (6.7% versus 15.0% in patients aged 16-20 years; p < 0.001), while a complex karyotype occurs more frequently in AML patients at the age of 61 and older (56.8% versus 2.7% in the group 16-20 years; p < 0.001). With age, more frequently detected is the most unfavourable monosomic karyotype with aberrations similar to those in myelodysplastic syndrome (57.1% in patients aged 16-60 years and in 80.0% in the group of 61 years of age and over).
Conclusion. Age-specific karyotype features detected may be explained by different biological mechanisms involved in leukosogenesis in young and elderly AML patients.
Keywords
About the authors
Sergey Vasil'evich Gritsaev
Email: rniiht@mail.ru
Irina Stepanovna Martynkevich
Email: genetics.spb@mail.ru
Lyudmila Sergeevna Martynenko
Email: genetics.spb@mail.ru
Marina Petrovna Ivanova
Email: genetics.spb@mail.ru
Vasilisa Yur'evna Aksenova
Email: genetics.spb@mail.ru <mailto:genetics.spb@mail.ru>
Mikhail Viktorovich Moskalenko
Email: genetics.spb@mail.ru <mailto:genetics.spb@mail.ru>
Irina Mikhaylovna Zapreeva
Email: rniiht@mail.ru
Kudrat Mugutdinovich Abdulkadyrov
Email: rniiht@mail.ru
S V Gritsaev
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
I S Martynkevich
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
L S Martynenko
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
M P Ivanova
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
V Yu Aksenova
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
M V Moskalenko
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
I M Zapreeva
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
K M Abdulkadyrov
Russian Research Institute of Hematology and Transfusiology, St-PetersburgRussian Research Institute of Hematology and Transfusiology, St-Petersburg
Sof'ya Aleksandrovna Tiranova
Email: rniiht@mail.ru
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