Multiple myeloma: innovations in diagnosis


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Abstract

Multiple myeloma (MM) belongs to the group of paraproteinemic hemoblastosis. Its clinical picture varies but the main clinical presentation is bone tumor proliferation resultant from enhanced resorption of tumor tissue related to bone marrow infiltration with plasmic cells, activation of osteoclasts. This leads to marked ossalgic syndrome and pathological bone fragility. MM often runs with nephropathy, immunodepression, hemopoietic disorders. Non-specific clinical manifestations of MM cause difficulties in making accurate diagnosis.Our clinic introduces innovative high-tech methods of examination including MR tomography of the body which detects the disease at early stages and, finally, allows us to prolong the patient's life.

About the authors

Priyanka Roshanovna Chovdkhuri

Mikhail Ivanovich Kryuchkov

Elena Anatol'evna Zinina

Sergey Pavlovich Morozov

Boris Mikhaylovich Brodetskiy

P R Chovdkhuri

President Administration's State Central Hospital with an outpatient department, Moscow

President Administration's State Central Hospital with an outpatient department, Moscow

M I Kryuchkov

President Administration's State Central Hospital with an outpatient department, Moscow

President Administration's State Central Hospital with an outpatient department, Moscow

E A Zinina

President Administration's State Central Hospital with an outpatient department, Moscow

President Administration's State Central Hospital with an outpatient department, Moscow

S P Morozov

President Administration's State Central Hospital with an outpatient department, Moscow

President Administration's State Central Hospital with an outpatient department, Moscow

B M Brodetsky

President Administration's State Central Hospital with an outpatient department, Moscow

President Administration's State Central Hospital with an outpatient department, Moscow

References

  1. Воробьев А. И. (ред.) Руководство по гематологии. 4-е изд. М.: Ньюдиамед; 2007.
  2. Brown R. D., Ho P. J., eds. Multiple myeloma: methods and protocols. Camperdown : Humana Press Inc.; 2005.
  3. Gertz M. A., Greipp Ph. R. Multiple myeloma and related plasma cell disorders. New York; 2004.
  4. Lecouvet F. E., Malghem J., Michaux L. et al. Skeletal survey in advanced multiple myeloma: radiographic versus MR imaging survey. Br. J. Haematol. 1999; 106: 35-39.
  5. Ghanem N., Lohrmann C., Engelhardt M. et al. Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey. Eur. Radiol. 2006; 16: 1005-1014.

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