Email this article A protective effect of Gly272Ser polymorphism of GNB3 gene in development of essential hypertension and its relations with environmental hypertension risk factors
- Authors: Polonikov A.V.1, Solodilova M.A.1, Ivanov V.P.1, Shestakov A.M.1, Ushachev D.V.1, Vyalykh E.K.1, Vasil'eva O.V.1, Polyakova N.V.1, Antsupov V.V.1, Kabanina V.A.1, Kupriyanova Y.S.1, Bulgakova I.V.1, Kozhukhov M.A.1, Tevs D.S.1, Polonikov AV2, Solodilova MA2, Ivanov VP2, Shestakov AM3, Ushachev DV3, Vyalykh EK3, Vasilyeva OV2, Polyakova NV2, Antsupov VV2, Kabanina VA2, Kupriyanova Y.S2, Bulgakova IV2, Kozhukhov MA3, Tevs DS3
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Affiliations:
- State Medical University, Kursk
- Regional hospital, Kursk
- Issue: Vol 83, No 4 (2011)
- Pages: 55-60
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30851
- ID: 30851
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Abstract
Material and methods. We studied DNA samples obtained from 205 EH patients and 207 healthy individuals. EH patients were treated in Kursk hospitals. Genotyping of GNB3 gene polymorphisms was conducted by polymerase chain reaction and restriction analysis.
Results. Prevalence of 825T allele of GNB3 gene in EH patients and healthy individual was 0.334 and 0.295, respectively, of 272S allele - 0.037 and 0.058, respectively. We found no significant differences by prevalence of genotypes of gene GNB3 polymorphisms C825T and G272S in EH patients and healthy individuals. Non-smoking carriers of 272GS genotype had a low risk of EH (OR 0.42 in 95% CI from 0.18 to 0.97; p = 0.04). Smokers had no protective effect of this genotype. The protective effect of 272GS genotype was also found in individuals with low or moderate alcohol drinking habits (OR 0.29 in 95% CI from 0.11 to 0.77, p = 0.02) and in individuals without chronic exposure to stress (OR 0.29 in 95% CI from 0.09 to 0.91, p = 0.04). In contrast, hard drinkers and patients exposed to chronic stress had no protective effect of heterozygous genotype 272GS of gene GNB3.
Conclusion. G272S polymorphism of GNB3 gene can be considered as a new genetic marker of predisposition to EH. The protective effect depends of environmental factors associated with high risk to develop EH.
About the authors
Aleksey Valer'evich Polonikov
Email: polonikov@rambler.ru
Mariya Andreevna Solodilova
Email: m-solodilova@rambler.ru
Vladimir Petrovich Ivanov
Email: medbiol@kursknet.ru
Aleksandr Mikhaylovich Shestakov
Email: shestakof@yandex.ru
Dmitriy Vladimirovich Ushachev
Email: okb@sovtest.ru
Ekaterina Konstantinovna Vyalykh
Email: kate-yours@mail.ru
Oksana Vladimirovna Vasil'eva
Email: vovpost@kursknet.ru
Natal'ya Vladimirovna Polyakova
Email: medbiol@kursknet.ru
Vladimir Vladimirovich Antsupov
Email: medbiol@kursknet.ru
Valentina Aleksandrovna Kabanina
Email: medbiol@kursknet.ru
Yana Sergeevna Kupriyanova
Irina Viktorovna Bulgakova
Mikhail Alekseevich Kozhukhov
Email: okb@sovtest.ru
Dmitriy Sergeevich Tevs
Email: okb@sovtest.ru
A V Polonikov
State Medical University, KurskState Medical University, Kursk
M A Solodilova
State Medical University, KurskState Medical University, Kursk
V P Ivanov
State Medical University, KurskState Medical University, Kursk
A M Shestakov
Regional hospital, KurskRegional hospital, Kursk
D V Ushachev
Regional hospital, KurskRegional hospital, Kursk
E K Vyalykh
Regional hospital, KurskRegional hospital, Kursk
O V Vasilyeva
State Medical University, KurskState Medical University, Kursk
N V Polyakova
State Medical University, KurskState Medical University, Kursk
V V Antsupov
State Medical University, KurskState Medical University, Kursk
V A Kabanina
State Medical University, KurskState Medical University, Kursk
Ya S Kupriyanova
State Medical University, KurskState Medical University, Kursk
I V Bulgakova
State Medical University, KurskState Medical University, Kursk
M A Kozhukhov
Regional hospital, KurskRegional hospital, Kursk
D S Tevs
Regional hospital, KurskRegional hospital, Kursk
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