A case of legionellesis pneumonia verified by isolation of legionella pneumophila serogroup 1 from bronchoalveolar lavage treated with levofloxacine and tigecycline


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Abstract

A male patient received non-chemotherapeutic drugs which induced deep neutropenia complicated with sepsis, bilateral pneumonia, acute respiratory insufficiency. Artificial pulmonary ventilation was applied. The examination of bronchoalveolar lavage showed the presence of the culture L. pneumophila (serogroup 1) in a concentration 2x103 CFU/ml. Antibacterial therapy with levofloxacin in a dose 1000 mg/day was conducted. In a week not only L.pneumophila but also Acinetobacter baumanii was isolated from bronchoalveolar lavage. Tigecyclin was added to levofloxacin treatment. Two air cavities were found in the left lung. The treatment reduced the size of these cavities, infiltrative changes in the lungs and respiratory insufficiency regressed. The patient was discharged from hospital. This case is the first case in Russia of L.pneumophila isolation from bronchoalveolar lavage. The case is also characterized by use of tigecycline for treatment of combined legionella and akinetobacterial infection and cavities in the lungs in legionella pneumonia.

About the authors

Gennadiy Martinovich Galstyan

Email: ggalst@rambler.ru

Mikhail Yur'evich Drokov

Email: mdrokov@gmail.com

Svetlana Aleksandrovna Katrysh

Email: ggalst@rambler.ru

Galina Aleksandrovna Klyasova

Email: klias@blood.ru

Elena Aleksandrovna Gilyazitdinova

Tat'yana Igorevna Karpova

Email: dragovtceva@ya.ru

Boris Ivanovich Marakusha

Email: marakusha@rambler.ru

Igor' Semenovich Tartakovskiy

Email: itartak@list.ru

G M Galstyan

Hematological Research Center, Moscow

Hematological Research Center, Moscow

M Yu Drokov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

S A Katrysh

Hematological Research Center, Moscow

Hematological Research Center, Moscow

G A Klyasova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

E A Gilyazitdinova

Hematological Research Center, Moscow

Hematological Research Center, Moscow

T I Karpova

N.F. Gamalei Research Institute of Epidemiology and Microbiology, Moscow

N.F. Gamalei Research Institute of Epidemiology and Microbiology, Moscow

B I Marakusha

N.F. Gamalei Research Institute of Epidemiology and Microbiology, Moscow

N.F. Gamalei Research Institute of Epidemiology and Microbiology, Moscow

I S Tartakovsky

N.F. Gamalei Research Institute of Epidemiology and Microbiology, Moscow

N.F. Gamalei Research Institute of Epidemiology and Microbiology, Moscow

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