Magnesium deficiency in cardiology


Cite item

Full Text

Abstract

The paper considers the consequences and causes of magnesium deficiency in patients with cardiovascular diseases. The features of magnesium metabolism in atherosclerosis, hypertension, and heart failure are described. Prospects of magnesium therapy in cardiology practice are discussed.

Full Text

Дефицит магния в кардиологии. - Аннотация. Рассматриваются последствия и причины дефицита магния при сердечно-сосудистых заболеваниях. Описаны особенности метаболизма магния при атеросклерозе, артериальной гипертонии, сердечной недостаточности. Обсуждаются перспективы терапии препаратами магния в кардиологической практике.
×

About the authors

O M Drapkina

B B Gegenava

References

  1. Zhang A., Cheng T.P., Altura B.T., Altura B.M. Mg2+ and caffeine-induced intracellular Ca2+ release in human vascular endothelial cells. Br J Pharmacol 1993; 109: 291-292.
  2. Fullerton D.A., Hahn A.R., Agrafojo J. et al. Magnesium is essential in mechanisms of pulmonary vasomotor control. J Surg Res 1996; 63: 93-97.
  3. Yokoyama S., Nishida H.I., Smith T.L., Kummerow F.A. Combined effects of magnesium deficiency and an atherogenic level of low density lipoprotein on uptake and metabolism of low density lipoprotein by cultured human endothelial cells. I Biochemical data Magnes Res 1994; 7: 87-95.
  4. Suttorp N., Fuchs T., Seeger W. et al. Role of Ca2+ and Mg2+ for endothelial permeability of water and albumin in vitro. Lab Invest 1989; 61: 183-191.
  5. Banai S., Haggroth L., Epstein S.E., Casscells W. Influence of extracellular magnesium on capillary endothelial cell proliferation and migration. Circ Res 1990; 67: 645-650.
  6. Dickens B.F., Weglicki W.B., Li Y.S., Mak I.T. Magnesium deficiency in vitro enhances free radical-induced intracellular oxidation and cytotoxicity in endothelial cells. FEBS Lett 1992; 311: 187-191.
  7. Драпкина О.М., Корнеева О.Н., Палаткина Л.О., Ивашкин В.Т. Статины при лечении хронической сердечной недостаточности. Атеросклероз и дислипидемии 2012; 1: 32-36.
  8. Maier J.A.M., Malpuech-Brugèreb C., Zimowskab W. et al. Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochimica et Biophysica Acta (BBA). Mol Basis Dis 2004; 1689: (1): 13-21.
  9. Ravn B., Korsholm T.L., Falk E. Oral magnesium supplementation induces favorable antiatherogenic changes in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 2001; 21: 858-862.
  10. Shechter M., Sharir M., Labrador M.J. et al. Oral magnesium therapy improves endothelial function in patients with coronary artery disease. Circulation 2000; 102: 2353-2358.
  11. Liao F., Folsom A.R., Brancati F.L. Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 1998; 136: 480-490.
  12. Maier J.A., Malpuech-Brugère C., Zimowska W. et al. Low magnesium promotes endothelial cell dysfunction: implications for atherosclerosis, inflammation and thrombosis. Biochim Biophys Acta-Mol Bas Dis 2004; 1689: 13-21.
  13. Killilea D., Maier J.A. A connection between magnesium deficiency and aging: new insights from cellular studies. Magnes Res 2008; 21: 77-82.
  14. Paravicini T.M., Yogi A., Mazur A., Touyz R.M. Dysregulation of vascular TRPM7 and annexin-1 is associated with endothelial dysfunction in inherited hypomagnesemia. Hypertension 2009; 53: 423-429.
  15. Resnick L.M., Bardicef O., Altura B.T. et al. Serum ionized magnesium: relation to blood pressure and racial factors. Am J Hypertens 1997; 10: 1420-1424.
  16. Touyz R.M., Schiffrin E.L. The effect of angiotensin II on platelet intracellular free magnesium and calcium ionic concentrations in essential hypertension. J Hypertens 1993; 11: 551-558.
  17. Ferrara L.A., Iannuzzi R., Castaldo A. et al. Long-term magnesium supplementation in essential hypertension. Cardiology 1992; 81: 25-33.
  18. Hiraga H., Oshima T., Yoshimura M. et al. Abnormal platelet Ca2+ handling accompanied by increased cytosolic free Mg2+ in essential hypertension. Am J Physiol 1998; 275 (2 pt 2): R574-R579.
  19. Whelton P.K., Klag M.J. Magnesium and blood pressure: review of the epidemiologic and clinical trial experience. Am J Cardiol 1989; 63: 26G-30G.
  20. Touyz R.M. Role of magnesium in the pathogenesis of hypertension. Mol Aspects Med 2003; 24: 107-136.
  21. Adamopoulos C., Pitt B., Sui X. et al. Low serum magnesium and cardiovascular mortality in chronic heart failure: a propensity-matched study. Int J Cardiol 2009; 136 (3): 270-277.
  22. Enselberg C.D., Simmons H.G., Mintz A.A. The effects of magnesium upon cardiac arrhythmias. Am Heart J 1950; 39: 703-712.
  23. Wester P.O. Electrolyte balance in heart failure and the role for magnesium ions. Am J Cardiol 1992; 70: 44C-49C.
  24. Ceremuzynski L., Gebalska J., Wolk R., Makowska E. Hypomagnesemia in heart failure with ventricular arrhythmias. Beneficial effects of magnesium supplementation. J Intern Med 2000; 247: 78-86.
  25. Valiathan S.M., Kartha C.C. Endomyocardial fibrosis - the possible connexion with myocardial levels of magnesium and cerium. Int J Cardiol 1990; 28: 1-5.
  26. Драпкина О.М., Гегенава Б.Б. Фиброз миокарда у больных сахарным диабетом. Рац фармакотер в кардиол 2013; 1: 62-65.
  27. Horton R., Biglieri E.G. Effect of aldosterone on the metabolism of magnesium. J Clin Endocrinol Metab 1962; 22: 1187-1192.
  28. Davies D.L., Fraser R. Do diuretics cause magnesium deficiency? Br J Clin Pharmacol 1993; 36: 1-10.
  29. Patrick S., Herbert M. When the MAGIC stops: magnesium in acute coronary syndromes - a lesson in medical humility. CJEM 2004; 6 (2): 123-125.
  30. Громова О.А., Торшин И.Ю., Рудаков К.В. и др. Недостаточность магния - достоверный фактор риска коморбидных состояний: результаты крупномасштабного скрининга магниевого статуса в регионах России. Фарматека 2013; 6: 116-129.

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2014 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

© 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies