Assessment of the role of matrix metalloproteinase-2 gene polymorphism in the development of chronic heart failure


Cite item

Full Text

Abstract

Aim. To study the impact of a polymorphic variant of the matrix metalloproteinase-3 (MMP-3) gene on the development and course of chronic heart failure (CHF) in patients with coronary heart disease. Subjects and methods. A total of 277 patients with New York Heart Association (NYHA) Functional Class (FC) II—IV CHF were examined. MMP-3 –1171 5A/6A genetic polymorphism was studied by polymerase chain reaction. A control group included 136 patients (mean age 53.6±4.8 years) with no signs of cardiovascular diseases, as evidenced by the examination. Results. The frequency of the 5A allele and the 5A/5A genotype of the 1171 5A/6A polymorphic locus in the MMP-3 gene proved to be higher in the patients with CHF than that in the control group. Thus, the variability of the 5A allele (odds ratio (OR), 1.39; 95% confidence interval (CI): 1.033 to 1.869; p=0.03) and the 5A/5A genotype (OR, 2.15; 95% CI: 1.131 to 4.070; p=0.02) was associated with increased risk for CHF. There were significant differences in the frequency of MMP-3 alleles and genotypes in relation to FC of CHF. The frequency of the 5A/5A genotype was substantially higher in the patients with NYHA FC IV CHF than that in those with NYHA FC II CHF (32.8% versus 15.2%; р=0.039). The frequency of the 5A allele was significantly higher in the patients with NYHA FC IV CHF than that in those with NYHA FC II CHF (55.5% and 39.3%; respectively; р=0.019). Thus, the carriage of the 5A allele and the 5A/5A genotype of the 1171 5A/6A polymorphic locus in the MMP-3 gene is a risk factor of severe CHF. Conclusion. The determination of ММР-3 –1171 5A/6A polymorphism may be recommended for the early prediction of a risk for the development and severe course of CHF.

References

  1. Фомин И.В. Эпидемиология хронической сердечной недостаточности в Российской Федерации. В кн: Агеев Ф.Т., Арутюнов Г.П., Беленков Ю.Н. и др. Хроническая сердечная недостаточность. М: ГЭОТАР-Медиа 2010: 7—77.
  2. Мареев В.Ю., Даниелян М.О., Беленков Ю.Н. От имени рабочей группы исследования ЭПОХА-О-ХСН. Сравнительная характеристика больных с ХСН в зависимости от величины ФВ по результатам Российского многоцентрового исследования ЭПОХА-О-ХСН. Сердеч недостат 2006; 4: 164—171.
  3. Rolande D.M., Fantini J.P., Cardinalli Neto A., Cordeiro J.A., Bestetti R.B. Prognostic determinants of patients with chronic systolic heart failure secondary to systemic arterial hypertension. Arq Bras Cardiol 2012; 98 (1): 76—84.
  4. Liu L., Eisen H.J. Epidemiology of heart failure and scope of the problem. Cardiol Clin 2014; 32 (1): 1—8.
  5. Бадин Ю.В., Фомин И.В. Выживаемость больных ХСН в когортной выборке Нижегородской области (данные 1998—2002 гг.). Сердеч недостат 2005; 4: 31—32.
  6. Hunt J.M., Aru G.M., Hayden M.R., Moore C.K., Hoit B.D., Tyagi S.C. Induction of oxidative stress and disintegrin metalloproteinase in human heart end-stage failure. Am J Physiol Lung Cell Mol Physiol 2002; 283 (2): L239—245.
  7. Гайковая Л.Б., Кухарчик Г.А., Нестерова Н.Н. Современные лабораторные маркеры в определении прогноза при остром коронарном синдроме и мониторинге терапии. Вестн аритмол 2009; 58: 52—59.
  8. Королева О.С., Затейщиков Д.А. Биомаркеры в кардиологии: регистрация внутрисосудистого воспаления. Фарматека 2007; 8/9: 30—36.
  9. Benjamin I.J. Matrix metalloproteinases: from biology to therapeutic strategies in cardiovascular disease. J Invest Med 2001; 49: 381—397.
  10. Creemers E., Cleutjens J., Smits J. Matrix metalloproteinase inhibition after myocardial infarction: a new approach to prevent heart failure? Circ Res 2001; 89: 201—210.
  11. Hojo Y., Ikeda U., Ueno S., Arakawa H., Shimada K. Expression of matrix metalloproteinases in patients with acute myocardial infarction. Jpn Circ J 2001; 65: 71—75.
  12. Mittal B., Mishra A., Srivastava A., Kumar S., Garg N. Matrix metalloproteinases in coronary artery disease. Adv Clin Chem 2014; 64: 1—72.
  13. Ye S. Influence of matrix metalloproteinase genotype on cardiovascular disease susceptibility and outcome. Cardiovasc Res 2006; 69 (3): 636—645.
  14. Капелько В.И. Ремоделирование миокарда: роль матриксных металлопротеиназ. Кардиология 2001; 6: 49—55.
  15. Li J., Schwimmbeck P.L., Tschope C., Leschka S., Husmann L., Rutschow S., Reichenbach F., Noutsias M., Kobalz U., Poller W., Spillmann F., Zeichhardt H., Schultheiss H.P., Pauschinger M. Collagen degradation in a murine myocarditis model: relevance of matrix metalloproteinase in association with inflammatory induction. Cardiovasc Res 2002; 56 (2): 235—247.
  16. Баранов В.С. Программа «Геном человека» как научная основа профилактической медицины. Вестн РАМН 2000; 10: 27—37.
  17. Medley T.L., Kingwell B.A., Gatzka C.D., Pillay P., Cole T.J. Matrix metalloproteinase-3 genotype contributes to age-related aortic stiffening through modulation of gene and protein expression. Circ Res 2003; 92 (11): 1254—1261.
  18. Ye S., Watts G.F., Mandalia S., Humphries S.E., Henney A.M. Preliminary report: genetic variation in the human stromelysin promoter is associated with progression of coronary atherosclerosis. Br Heart J 1995; 73 (3): 209—215.
  19. Humphries S.E., Martin S., Cooper J., Miller G. Interaction between smoking and the stromelysin-1 (MMP3) gene 5A/6A promoter polymorphism and risk of coronary heart disease in healthy men. Ann Hum Genet 2002; 66 (5—6): 343—352.
  20. Xu X., Wang L., Xu C., Zhang P., Yong F., Liu H., Wang J., Shi Y. Variations in matrix metalloproteinase-1, -3, and -9 genes and the risk of acute coronary syndrome and coronary artery disease in the Chinese Han population. Coron Artery Dis 2013; 24 (4): 259—265.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2015 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies