Functional and laboratory characteristics in the concomitance of asthma and obesity at a young age


Cite item

Full Text

Abstract

Aim. To study the peripheral blood level of leptin and adiponectin and their possible effect on the functional status of the respiratory system in young asthmatic patients in relation to body mass index (BMI) for the optimization of asthma therapy. Subjects and methods. Examinations were made in 133 people, including a study group of 93 patients with asthma who were divided into 2 groups according to BMI: 1) those with a BMI of less 25 kg/m2 and 2) those with a BMI of 30 kg/m2 or more, as well as a control group of 40 apparently healthy patients. The investigators studied external respiratory function (ERF), the peripheral blood levels of leptin and adiponectin, the biochemical composition of plasma, by determining total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. Results. Lipid metabolic disorders as dyslipidemia and hypercholesterolemia, increased severity of disease, and decreased ERF were recorded in the concomitance of obesity and asthma. The peripheral blood level of leptin in young asthmatic patients with obesity was found to be associated with higher BMI. Conclusion. A more severe course of disease presenting with decreased ERF, impaired lipid metabolism, and elevated peripheral blood leptin levels were noted in the concomitance of asthma and obesity at a young age.

References

  1. Gershon A, Wang C, Guan J, To Т. Burden of comorbidity in individuals with asthma. Thorax. 2010;65(7):612-618. doi: 10.1136/thx.2009.131078.
  2. Lenzer J. Obesity related illness consumes a sixth of US healthcare budget. BMJ. 2010;341:6014-6014. doi: 10.1136/bmj.c6014.
  3. Минеев В.Н., Лалаева Т.М., Васильева Т.С., Трофимов В.И. Фенотип бронхиальной астмы с ожирением. Пульмонология. 2012;2:102-107.
  4. American Lung Association Asthma Clinical Research Centers. Clinical trial of low-dose theophylline and montelukast in patients with poorly controlled asthma. Am J Respir Crit Care Med. 2007;175(3):235-242. doi: 10.1164/rccm.200603-416oc.
  5. Giouleka P, Papatheodorou G, Lyberopoulos P, Karakatsani A, Alchanatis M, Roussos C, Papiris S, Loukides S. Body mass index is associated with leukotriene inflammation in asthmatics. Eur J Clin Invest. 2011;41(1):30-38. doi: 10.1111/j.1365-2362.2010.02371.x.
  6. Dixon AE. Adipokines and asthma. Chest. 2009;135(2):287-294. doi: 10.1378/chest.08-2263.
  7. Фадеева А.А., Приступа Л.Н. Эффективность ингаляционных глюкокортикоидов у больных с бронхиальной астмой и висцеральным ожирением. Аллергология и иммунология. 2009;10(2):190.
  8. Shore SA. Obesity and asthma: Possibe mechanisms. J Allergy Clin Immunol. 2008;121(5):1087-1093. doi: 10.1016/j.jaci.2008.03.004.
  9. Global Initiative for Asthma. Global strategy for asthma management andprevention. Updated 2012 [Electronic resource] // ginasthma.org. URL: http://www.ginasthma.org/local/uploads/files/GINA_Report_March13.pdf.
  10. Федеральные клинические рекомендации по диагностике и лечению бронхиальной астмы. Российское респираторное общество. 2013. http://www.pulmonology.ru/download/clinasthma 22013.docx
  11. Stern JS, Hirsch J, Blair SN, Foreyt JP, Frank A, Kumanyika SK, Madans JH, Marlatt GA, St Jeor ST, Stunkard AJ. Weighing the options: criteria for evaluating weight-management programs. The Committee to Develop Criteria for Evaluating the Outcomes of Approaches to Prevent and Treat Obesity. Obes Res. 1995;3(6):591-604.
  12. Rio-Navarro В, Cisneros-Rivero M, Berber-Eslava A, Espínola-Reyna G, Sienra-Monge J. Exercise induced bronchospasm in asthmatic and non-asthmatic obese children. Allergol Immunopathol (Madr). 2000;28(1):5-11.
  13. Shore SA. Obesity and asthma: location, location, location. Eur Respir J. 2013;41(2):253-254. doi: 10.1183/09031936.00128812.
  14. Cohn JN, Quyyumi AA, Hollenberg NK, Jamerson KA. Markers for Cardiovascular Disease. Functional Markers. Circulation. 2004;109:IV31-IV46. doi: 10.1161/01.cir.0000133442.99186.39.
  15. Климов А.Н., Плавинский С.И. О причинах высокого уровня ХСЛПВП в Санкт-Петербурге. Кардиология. 1997;3:22-25.
  16. Гришин О.В., Митрофанов И.М., Устюжанинова Н.В., Гультяева В.В., Уманцева Н.Д. Система внешнего дыхания при переходе от здоровья к хроническим заболеваниям. Бюллетень СО РАМН. 2004;2:118-122.
  17. Демко И.В., Собко Е.А., Чубарова С.В., Соловьева И.А., Крапошина А.Ю., Медведева Н.Н., Вахтина Л.Ю., Жуков Е.Л., Ищенко О.П., Жегалов П.С. Особенности системного воспаления, функции внешнего дыхания и морфологической структуры слизистой оболочки бронхов при тяжелой бронхиальной астме. Сибирское медицинское обозрение. 2014;5:47-52.
  18. Астафьева Н.Г., Гамова И.В., Удовиченко Е.Н., Перфилова И.А. Ожирение и бронхиальная астма. Лечащий врач. 2014;4:8-13.
  19. Яшин Д.А., Калев О.Ф., Калева Н.Г., Яшина Л.М. Распространенность избыточной массы тела и ожирения среди работников промышленного предприятия по данным многолетних исследований. Казанский медицинский журнал. 2012;93(3):529-532.
  20. Nigro E, Daniele A, Scudiero O, Monaco M, Roviezzo F, D’Agostino B, Mazzarella G, Bianco A. Adiponectin in Asthma: Implications for Phenotyping. CPPS;16(3):182-187. doi: 10.2174/1389203716666150120095342.
  21. Leiria LO, Martins MA, Saad MJ. Obesity and asthma: beyond T(H)2 inflammation. Metabolism. 2015;64(2):172-181. doi: 10.1016/j.metabol.2014.10.002.
  22. Ruhl CE, Everhart JE. Leptin concentrations in the United States: relations with demographic and anthropometric measures. Am J Clin Nutrition. 2001;74(3):295-301.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2016 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies