Adiponectin in health and disease


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Abstract

Over the past 20 years after the discovery of adiponectin, much knowledge about its effect in health and disease has been gained. Adiponectin has antidiabetic, antiatherogenic, anti-inflammatory, immunomodulatory, metabolic, vasoprotective, and antiapoptotic properties. However, an understanding stems from the given literature review that much remains to be explored. Adiponectin has not yet commonly used in clinical practice, but cardiologists, endocrinologists, pediatricians, oncologists, and physicians of many specialties are interested in its preventive and therapeutic applications.

References

  1. Косыгина А.В., Сосунов В.В., Петеркова В.А., Дедов И.И. Экспрессия гена адипонектина (ADIPOQ) в подкожной и висцеральной жировой ткани и уровень адипонектина в сыворотке крови у детей. Проблемы эндокринологии. 2010;6:5-8.
  2. Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013;503(7477):493-499. doi: 10.1038/nature12656
  3. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications. 1999;257(1):79-83. doi: 10.1006/bbrc.1999.0255
  4. Martinez Cantarin MP, Waldman SA, Doria C, Frank AM, Maley WR, Ramirez CB, Keith SW, Falkner B. The adipose tissue production of adiponectin is increased in end stage renal disease. Kidney Int. 2013;83(3):487-494. doi: 10.1038/ki.2012.421
  5. Li Y, Wu QH, Jiao ML, Fan XH, Hu Q, Hao YH, Liu RH, Zhang W, Cui Y., Han LY. Gene-environment interaction between adiponectin gene polymorphisms and environmental factors on the risk of diabetic retinopathy. J Diabet Invest. 2015;6(1):56-66. doi: 10.1111/jdi.12249
  6. Zhang L, Li MM, Corcoran M, Zhang S, Cooper GJ. Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin. Mol Cell Endocrinol. 2015;399:164-177. doi: 10.1016/j.mce.2014.09.014
  7. Meyer LK, Ciaraldi TP, Henry RR, Wittgrove AC, Phillips SA. Adipose tissue depot and cell size dependency of adiponectin synthesis and secretion in human obesity. Adipocyte. 2013;2(4):217-226. doi: 10.4161/adip.24953
  8. Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF. A novel serum protein similar to C1q, produced exclusively in adipocytes. JBiolChem. 1995;270(45):26746-26749. doi: 10.1074/jbc.270.45.26746
  9. Беляева О.Д., Важенова Е.А., Березина А.В., Большакова О.О., Чубенко Е.А., Гаранина А.Е., Вадмаева М.И., Тимошин В.Б., Ларионова В.И., Баранова Е.И. Уровень адипонектина у пациентов с абдоминальным ожирением — носителей различных генотипов гена адипонектина. Вестник СПбГУ. 2009;11(4):36-48.
  10. Бутрова С.А., Ершова Е.В., Ильин А.В., Мельниченко Г.А. Адипонектин у мужчин с абдоминальным ожирением. Ожирениеиметаболизм. 2006;2:32-36.
  11. Santini F, Marsili A, Mammoli C, Valeriano R, Scartabelli G, Pelosini C, Giannetti M, Centoni R, Vitti P, Pinchera A. Serum concentrations of adiponectin and leptin in patients with thyroid dysfunctions. J Endocrinol Investigat. 2004;27(2):5-7. doi: 10.1007/BF03346252
  12. Schoppen S, Riestra P, García-Anguita A, López-Simón L, Cano B, de Oya I, de Oya M, Garcés C. Leptin and adiponectin levels in pubertal children: relationship with anthropometric variables and body composition. Clin Chem Lab Med. 2010;48(5):707-711. doi: 10.1515/CCLM.2010.142
  13. Al-Hamodi Z, Al-Habori M, Al-Meeri A, Saif-Ali R. Assosiation of adipokines , leptin/adiponectin ratio and C-reactive protein with obesity and tipe 2 diabetes mellitus. Diabet Metabol Syndrome. 2014;6(1):99. doi: 10.1186/1758-5996-6-99
  14. Kovacova Z, Tencerova M, Roussel B, Wedellova Z, Rossmeislova L, Langin D, Polak J, Stich V. The impact of obesity on secretion of adiponectin multimeric isoforms differs in visceral and subcutaneous adipose tissue. Int J Obes. 2012;36(10):1360-1365. doi: 10.1038/ijo.2011.223
  15. Tagami T, Satoh N, Usui T, Yamada K, Shimatsu A, Kuzuya H. Adiponectin in anorexia nervisa and bulimia nervosa. J Clin Endocrinol Metabol. 2004;89(4):1833-1837. doi: 10.1210/jc.2003-031260
  16. Hwang JY, Park JE, Choi YJ, Huh KB, Chang N, Kim WY. Carbohydrate intake interacts with SNP276G>T polymorphism in the adiponectin gene to affect fasting blood glucose, HbA1C, and HDL cholesterol in Korean patients with type 2 diabetes. J Am Coll Nutrition. 2013;32(3):143-150. doi: 10.1080/07315724.2013.791795
  17. Kamari Y, Grossman E, Oron-Herman M, Peleg E, Shabtay Z, Shamiss A, Sharabi Y. Metabolic stress with a high carbohydrate diet increases adiponectin levels. Hormone Metabol Res. 2007;39(5):384-388. doi: 10.1055/s-2007-976534
  18. Romacho T, Glosse P, Richter I, Elsen M, Schoemaker MH, van Tol EA, Eckel J. Nutritional ingredients modulate adipokine secretion and inflammation in human primary adipocytes. Nutrients. 2015;7(2):865-886 doi: 10.3390/nu7020865
  19. Matsui S, Yasui T, Keyama K, Tani A. High adiponectin level in late postmenopausal women with normal renal function. ClinChimActa. 2014;430:104-108. doi: 10.1016/j.cca.2013.12.037
  20. Косыгина А.В. Гормоны жировой ткани — адипонектин и висфатин и экспрессия контролирующих их генов при ожирении у детей: Автореф. ... канд. мед. наук. М.; 2011.
  21. Березин А.Е., Кремзер А.А. Информативность адипонектина как маркера кардиометаболического риска. Запорожскиймедицинскийжурнал. 2012;5:82-87
  22. Jung UJ, Choi MS. Obesity and its metabolic complications: the role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. Int J Mol Scie. 2014;15(4):6184-6223. doi: 10.3390/ijms15046184
  23. Barb D, Pazaitou-Panayiotou K, Mantzoros CS. Adiponectin: a link between obesity and cancer. Expert Opin Invest Drugs. 2006;15(8):917-931. doi: 10.1517/13543784.15.8.917
  24. Mediano MF, Neves FA, Cunha EP, Moura AS, Moura AS, Sichieri R. Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of smoll-volume, home-based exercise program. Clinics (Sao Paulo). 2013;68(8):1121-1127. doi: 10.6061/clinics/2013(08)10
  25. Вербовой А.Ф., Скудаева Е.С. Уровни адипонектина, резистина и 7истентность у пациентов с нарушением толерантности к глюкозе. Медицинский альманах. 2011;5(18):164-166.
  26. Kelly KR, Navaneethan SD, Solomon TP, Haus JM, Cook M, Barkoukis H, Kirwan JP. Lifestyle-induced decrease in fat mass improves adiponectin secretion in obese adults. Med ScieSports Exercise. 2014;46(5):920-926. doi: 10.1249/MSS.0000000000000200
  27. Grossini E, Prodam F, Walker GE, Sigaudo L, Farruggio S, Bellofatto K, Marotta P, Molinari C, Mary D, Bona G, Vacca G. Effect of monomeric adiponectin on cardiac function and perfusion in anesthetized pig. J Endocrinol. 2014;222(1):137-149. doi: 10.1530/JOE-14-0170
  28. Lindberg S, Jensen JS, Pedersen SH, Galatius S, Frystyk J, Flyvbjerg A, Bjerre M, Mogelvang R. Lindberg Low adiponectin levels and increased risk of type 2 diabetes in patients with myocardial infarction. Diabetes Care. 2014;37(11):3003-3008. doi: 10.2337/dc14-0932
  29. Yamauchi T, Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes. 2008;32(7):13-18. doi: 10.1038/ijo.2008.233
  30. Carbone F, La Rocca C, Matarese G. Immunological functions of leptin and adiponectin. Biochimie. 2012;94(10):2082-2088. doi: 10.1016/j.biochi.2012.05.018
  31. Fasshauer M, Bluher M, Stumvoll M, Tonessen P, Faber R, Stepan H. Differential regulation of visfatin and adiponectin in pregnancies with normal and abnormal placental function. Clin Endocrinol. 2007;66(3):434-439. doi: 10.1111/j.1365-2265.2007.02751.x
  32. Grossmann ME, Ray A, Nkhata KJ, Malakhov DA, Rogozina OP, Dogan S, Cleary MP. Obesity and breast cancer: status of leptin and adiponectin in pathological processes. Cancer Metastasis Rev. 2010;29(4):641-653. doi: 10.1007/s10555-010-9252-1
  33. Nien JK, Mazaki-Tovi S, Romero R, Erez O, Kusanovic JP, Gotsch F, Pineles BL, Gomez R, Edwin S, Mazor M, Espinoza J, Yoon BH, Hassan SS. Plasma adiponectin concentrations in non-pregnant, normal pregnancy and overweight pregnant women. J Perinatal Med. 2007;35(6):522-531. doi: 10.1515/JPM.2007.123
  34. Mazaki-Tovi S, Romero R, Kusanovic JP, Erez O, Vaisbuch E, Gotsch F, Mittal P, Than GN, Nhan-Chang C, Chaiworapongsa T, Edwin S, Camacho N, Nien JK, Hassan SS. Adiponectin multimers in normal pregnancy. J Maternal-Fetal Neonatal Med. 2008;21(11):796-815. doi: 10.1080/14767050802266881
  35. Paradisi G, Ianniello F, Tomei C, Bracaglia M, Carducci B, Gualano MR, La Torre G, Banci M, Caruso A. Longitudinal changes of adiponectin, carbohydrate and lipid metabolism in pregnant women at high risk for gestational diabetes. Gynecol Endocrinol. 2010;26(7):539-545. doi: 10.3109/09513591003632084
  36. Ianniello F, Quagliozzi L, Caruso A, Paradisi G. Low adiponectin in overweight/obese women: association with diabetes during pregnancy. Eur Rev Med Pharmacol Scie. 2013;17(23):3197-3205.
  37. Matyjaszek-Matuszek B, Lenart-Lipińska M, Kowalczyk-Bołtuć J, Wożniak S, Paszkowski T. Postpartum adiponectin changes in women with gestational diabetes. Ann AgriculturalEnvironmental Med. 2014;21(4):850-853. doi: 10.5604/12321966.1129945
  38. Cantley J. The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis. Mammalian Genome. 2014;25(9-10):442-454. doi: 10.1007/s00335-014-9538-7
  39. Ma H, Cui F, Dong JJ, You GP, Yang XJ, Lu HD, Huang YL. Therapeutic effects of globular adiponectin in diabetic rats with nonalcoholic fatty liver disease. World J Gastroenterol. 2014; 20(40):14950-14957. doi: 10.3748/wjg.v20.i40.14950
  40. Shibata R, Ouchi N, Takahashi R, Teracura Y, Ohashi K, Ikeda N, Higuchi A, Terasaki H, Kihara S, Murohara T. Omentin as a novel biomarker of metabolic risk factors. Diabetol Metabol Syndrome. 2012;4(27):1-4. doi: 10.1186/1758-5996-4-37
  41. Emst MC, Sinal CJ. Chemerin: at the crossroads of inflammation and obesity. Trends Endocrinol Metabol. 2010;21(11):660-667. doi: 10.1016/j.tem.2010.08.001
  42. Cekmez F, Canpolat FE, Pirgon O, Cetinkaya M, Aydinoz S, Suleymanoglu S, Ipcioglu OM, Sarici SU. Apelin, vaspin, visfatin and adiponectin in large for gestational age infants with insulin resistance. Cytokine. 2011;56(2):387-391. doi: 10.1016/j.cyto.2011.06.007
  43. Tamura Y, Kawao N, Yano M, Okada K, Matsuo O, Kaji H. Plasminogen activator inhibitor-1 deficiency ameliorates insulin resistance and hyperlipidemia but not bone loss in obese female mice. Endocrinology. 2014;155(5):1708-1717. doi: 10.1210/en.2013-1888
  44. Танянский Д.А., Фирова Э.М., Шатилина Л.В., Денисенко А.Д. Роль адипокинов и неэстерифицированных жирных кислот в развитии инсулинорезистентности. Проблемы эндокринологии. 2009;55(3):13-17.
  45. Альтшулер Н.Э., Петунина Н.А., Николаев А.П., Чернышова Т.В. Сравнительный анализ концентрации гормонов жировой ткани, показателей липидного обмена и инсулинорезистентности при субклиническом гипотиреозе в зависимости от наличия /отсутствия заместительной терапии левотироксином. Клиническаяиэкспериментальнаятиреоидология. 2011;3:53-58.
  46. Kravchun P, Kadykova O, Gabisoniia T. The role of adipokines in formation of lipid and carbohydrate metabolic disorders in patients with cardiovascular disease. Georgian Med News. 2012;213:26-31.
  47. Савельева С.А., Крячкова A.A., Курумова К.О, Шамхалова М.Ш., Кутырина И.М., Шестакова М.В. Ожирение — фактор риска поражения почек у больных сахарным диабетом 2-го типа. Сахарный диабет. 2010;2:45-50.
  48. Никитина И.Л., Тодиева А.М., Каронова Т.Л., Гринева Е.Н. Взаимосвязь уровня витамина D, содержания адипоцитокинов и метаболических нарушений у детей с ожирением. Бюллетень Федерального центра сердца, крови и эндокринологии им. В.А. Алмазова. 2013 Июнь: 37-46.
  49. Титов В.Н. Биологическая функция трофологии (питания) и патогенез метаболического синдрома — физиологического переедания. Филогенетическая теория общей патологии, лептин и адипонектин. Кардиологический вестник. 2014;1:79-93.
  50. Pereira RI, Snell-Bergeon JK, Erickson C, Shauer IE, Bergman BC, Rewers M, Maahs DM. Adiponectin dysregulation and insulin resistance in type 1 diabetes. J Clin Endocrinol Metabol. 2012;97(4):E642-647. doi: 10.1210/jc.2011-2542
  51. Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, Costagliola C, Bianco A, Daniele A. New insight into adiponectin role in obesity and obesity-related diseases. BioMed Research International 2014;2014:1-14. doi: 10.1155/2014/658913
  52. Jia T, Carrero JJ, Lindholm B, Stenvinkel P. The complex role of adiponectin in chronic kidney disease. Biochimie. 2012;94(10): 2150-2156. doi: 10.1016/j.biochi.2012.02.024
  53. Kawano J, Arora R. The role of adiponectin in obesity, diabetes, and cardiovascular desease. J CardioMetabolic Syndrome. 2009;4(1):44-49. doi: 10.1111/j.1559-4572.2008.00030.x
  54. Tamang HK, Timilsina U, Singh KP, Shrestha S, Pandey B, Basnet S, Waiba B, Shrestha U. Assessment of adiponectin level in obese and lean Nepalese population and its possible correlation with lipid profile: A cross-sectional study. Indian J Endocrinol Metab. 2013;17(1):349-354. doi: 10.4103/2230-8210.119618
  55. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, Nagaretani H, Matsuda M, Komuro R, Ouchi N, Kuriyama H, Hotta K, Nakamura T, Shimomura I, Matsuzawa Y. PPAR-gamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. Diabetes. 2001;50(9):2094-2099. doi: 10.2337/diabetes.50.9.2094
  56. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Charalampidis P, Livadas S, Kollias A, Sabico SL, Chrousos GP. Visceral adiposity index is highly associated with adiponectin values and glycaemic disturbances. Eur J Clin Invest. 2013;43(2): 183-189. doi: 10.1111/eci.12030
  57. Mallamaci F, Zoccali C, Cuzzola F, Tripepi G, Cutrupi S, Parlongo S, Tanaka S, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y. Adiponectin in essential hypertension. J Nephrol. 2002;15(5):507-511.
  58. Rojas E, Rodríguez-Molina D, Bolli P, Israili ZH, Faría J, Fidilio E, Bermúdez V, Velasco M. The role of adiponectin in endothelial dysfunction and hypertension. Cur Hypertens Reports. 2014;16(8): 463. doi: 10.1007/s11906-014-0463-7
  59. Del Turco S, Navarra T, Gastaldelli A, Basta G. Protective role of adiponectin on endothelial dysfunction induced by AGEs: a clinical and experimental approach. Microvasc Res. 2011;82(1):73-76. doi: 10.1016/j.mvr.2011.03.003
  60. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB. Plasma adiponectin levels and risk of myocardial infarction in men. JAMA. 2004;291(14):1730-1737. doi: 10.1001/jama.291.14.1730
  61. Shams M, Rasekhi Kazerouni A, Ostovan MA, Omrani GR. The relationship between serum adiponectin levels with the presence and severity of coronary artery disease. Arch Iranian Med. 2012;15(10):611-616.
  62. Lawlor DA, Davey Smith G, Ebrahim S, Thompson C, Sattar N. Plasma adiponectin levels are associated with insulinresistance, but do not predict future risk of coronary heart disease in women. J Clin Endocrinol Metab. 2005;90(10):5677-5683. doi: 10.1210/jc.2005-0825
  63. Kanaya AM, Wassel Fyr C, Vittinghoff E, Havel PJ, Cesari M, Nicklas B, Harris T, Newman AB, Satterfield S, Cummings SR. Health ABC study. Serum adiponectin and coronary heart disease risk in older Black and White Americans. J Clin Endocrinol Metab. 2006;91(12):5044-5050. doi: 10.1210/jc.2006-0107
  64. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Rev Immunol. 2011;11(2):85-97. doi: 10.1038/nri2921
  65. Fantuzzi G. Adiponectin and inflammation: consensus and controversy. J Aller Clin Immunol. 2008;121(2):326-330. doi: 10.1016/j.jaci.2007.10.018
  66. Cheng X, Folco EJ, Shimizu K, Libby P. Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T-cells. J Biol Chem. 2012;287(44):36896-36904. doi: 10.1074/jbc.M112.409516
  67. Inoue T, Sugiyama H, Kitagawa M, Takiue K, Morinaga H, Ogawa A, Kikumoto Y, Kitamura S, Maeshima Y, Makino H. Suppression of adiponectin by aberrantly glycosylated IgA1 in glomerular mesangial cells in vitro and in vivo. PLoS One. 2012;7(3):e33965. doi: 10.1371/journal.pone.0033965
  68. Byun SH, Kwon EB, Kim SY. The relationship between serum adiponectin and inflammatory cytokines in obese Korean juveniles. Korean J Pediatr. 2014;57(12):533-537. doi: 10.3345/kjp.2014.57.12.533
  69. Litvinova L, Atochin D, Vasilenko M, Fattakhov N, Zatolokin P, Vaysbeyn I, Kirienkova E. Role of adiponectin and proinflammatory gene expression in adipose tissue chronic inflammation in women with metabolic syndrome. Diabetol Metabol Syndrome. 2014;6(1):137. doi: 10.1186/1758-5996-6-137
  70. Xydakis AM, Case CC, Jones PH, Hoogeveen RC, Liu MY, Smith EO, Nelson KW, Ballantyne CM. Adiponectin, inflammation, and the expression of the metabolic syndrome in obese individuals: the impact of rapid weight loss through caloric restriction. J Clin Endocrinol Metab. 2004;89(6):2697-2703. doi: 10.1210/jc.2003-031826
  71. Yildiz BO, Aksoy DY, Harmanci A, Unluturk U, Cinar N, Isildak M, Usman A, Bayraktar M. Effects of L-thyroxine therapy on circulating leptin and adiponectin levels in subclinical hypothyroidism: a prospective study. ArchMedRes. 2013;44(4):317-320. doi: 10.1016/j.arcmed.2013.04.010
  72. Петунина Н.А., Альтшулер Н.Э. Сравнительный анализ уровней адипонектина, лептина, резистина, показателей липидного обмена и инсулинорезистентности при субклиническом гипотиреозе в зависимости от наличия/отсутст-вия заместительной терапии левотироксином. Consilium medicum. 2013;15(4):12-15.
  73. Iglesias P, Alvarez Fidalgo P, Codoceo R, Diez JJ. Serum concentrations of 73adipocytkines in patients with hyperthyroidism and hypothyroidism before and after control of thyroidfunction. Clin Endocrinol. 2003;59(50):621-629. doi: 10.1046/j.1365-2265.2003.01897.x
  74. Aragao CN, Zouza LL, Cabanelas A, Oliveira KJ, Pazos-Moura CC. Effect of experimental Hypo- and hyperthyroidism on serum adiponectin. Metabolism. 2007;56(10):6-11. doi: 10.1016/j.metabol.2006.08.015
  75. Seifi S, Tabandeh MR, Nazifi S, Saeb M, Shirian S, Sarkoohi P. Regulation of adiponectin gene expression in adipose tissue by thyroid hormones. J Physiol Biochem. 2012;68(2):193-203. doi: 10.1007/s13105-011-0131-1
  76. Cinar N, Gurlek A. Association between novel adipocytokines adiponectin, vaspin, visfatin, and thyroid: An experimental and clinical update. Endocrine Connect. 2013;2(4):30-38. doi: 10.1530/EC-13-0061
  77. Asano T, Watanabe K, Kubota N, Gunii T, Omata M, Kadowaki T, Ohnishi S. Adiponectin knockout mice on high fat diet develop fibrosing steatohepatitis. J Gastroenterol Hepatol. 2009;24(10): 1669-1676. doi: 10.1111/j.1440-1746.2009.06039.x
  78. Wang SN, Yeh YT, Yu ML, Dai CY, Chi WC, Chung WL, Lee KT. Hyperleptinaemia and hypoadiponectinaemia are associated with gallstone disease. Eur J Clin Invest. 2006;36(3):176-180. doi: 10.1111/j.1365-2362.2006.01611.x
  79. Wang SN, Yeh YT, Yu ML, Wang CL, Lee KT. Serum adiponectin levels in cholesterol and pigment cholelithiasis. Br J Surg. 2006;93(8):981-986. doi: 10.1002/bjs.5395
  80. Ogiyama H, Kamada Y, Kiso S, Araki H, Yamada T, Nishihara T, Watabe K, Tochino Y, Kihara S, Funahashi T, Kanno K, Shimomura I, Tsutsui S, Tazuma S, Hayashi N. Lack of adiponectin promotes formation of cholesterol gallstones in mice. Biochem Biophys Res Communicat. 2010;399(3):352-358. doi: 10.1016/j.bbrc.2010.07.075
  81. Breitfeld J, Sandvoss R, Schleinitz D, Böttcher Y, Fasshauer M, Blüher M, Stumvoll M, Kovacs P, Wittenburg H, Tönjes A. Serum adiponectin and progranulin levels are associated with gallstone disease. Exper Clin Endocrinol Diab. 2014;122(10):559-563. doi: 10.1055/s-0034-1376969
  82. Freedland SJ, Sokoll LJ, Platz EA, Mangold LA, Bruzek DJ, Mohr P, Yiu SK, Partin AW. Association between serum adiponectin and pathological stage and grade in men undergoing radical prostatectomy. J Urol. 2005;174(4 Pt 1):1266-1270. doi: 10.1097/01.ju.0000173093.89897.97
  83. Porcile C, Di Zazzo E, Monaco ML, D’Angelo G, Passarella D, Russo C, Di Costanzo A, Pattarozzi A, Gatti M, Bajetto A, Zona G, Barbieri F, Oriani G, Moncharmont B, Florio T, Daniele A. Adiponectin as novel regulator of cell proliferation in human glioblastoma. J Cell Physiol. 2014;229(10):1444-1454. doi: 10.1002/jcp.24582
  84. Saleh S, El-Maraghy N, Reda E, Barakat W. Modulation of diabetes and dyslipidemia in diabetic insulin-resistant rats by mangiferin: role of adiponectin and TNF-α. Anais da Academia Brasileira de Ciências. 2014;86(4):1935-1948. doi: 10.1590/0001-3765201420140212
  85. Wanders D, Plaisance EP, Judd RL. Lipid-lowering drugs and circulating adiponectin. Vitamins Hormones. 2012;90:341-374. doi: 10.1016/B978-0-12-398313-8.00013-0
  86. Bai YM, Chen JY, Yang WS, Chi YC, Liou YJ, Lin CC, Wang YC, Lin CY, Su TP, Chou P. Adiponectin as a potential biomarker for the metabolic syndrome in Chinese patients taking clozapine for schizophrenia. J Clin Psychiatry. 2007;68(12):1834-1839. doi: 10.2337/diabetes.50.9.2094
  87. Sahebkar A, Watts GF. Fibrate therapy and circulating adiponectin concentrations: a systematic review and meta-analysis of randomized placebo-controlled trials. Atherosclerosis. 2013;230(1):110-120. doi: 10.1016/j.atherosclerosis.2013.06.026

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